Mini Bioreactors and Micro Bioreactors Market, Distribution by Type of Cell Culture (Mammalian, Microbial, Viral, Insect and Others), Mode of Operation (Batch/Fed-Batch and Continuous), End User (Biopharmaceutical Industry and Academic Institutes) and Key Geographical Regions (North America, Europe, Asia-Pacific, and Rest of the World): Industry Trends and Global Forecasts, 2022-2035

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Example Insights

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Overview

With several blockbuster therapies (such as Humira®, Rituxan®, Lantus®, Avastin®, Herceptin® and Remicade®) and a robust pipeline of product / therapy candidates, the biopharmaceutical market is anticipated to witness significant growth in the next few years. However, it has been established that biologic drug development is a complex, time-consuming and capital-intensive process. These complex molecules require highly engineered specialized equipment, innovative downstream technologies, optimal storage and handling conditions, to ensure safety, efficacy and stability. In addition to the development of biologics, there remains a need to improve productivity, growth medium, process development and process optimization. Over time, a variety of advanced technologies and process analytical tools have been developed to accelerate the overall process. Traditionally, the process involves screening of cell lines in shake flask cultures, testing of successful candidates in bench-top bioreactors prior to pilot-scale studies. The need to carry out a large number of cell cultivations has resulted in the deployment of small-scale bioreactor systems, also known as minibioreactors, which can process culture volume ranging from 250 mL to 15 L and offer a high-throughput solution to process development. These minibioreactors allow scaling-down mammalian and microbial cell processes, scaling up the production by generating products in a more concentrated form. In addition, minibioreactors enable faster experimental throughput at relatively lower costs and allow parallel bioprocessing of samples, thereby reducing the downtime and increasing the number of batches produced in a given period of time.

Presently, more than 55 minibioreactors, developed by around 30 companies, are available for high-throughput media cultivation, process development and optimization. The stakeholders are taking several initiatives to incorporate a variety of features for monitoring of different control parameters, such as CO2 levels, dissolved oxygen, pH and temperature ranges, thereby allowing the users to analyze and determine essential conditions of the culture environment and optimize the overall performance. Further, the growing interest in precision medicine has also brought up the demand for small-scale production and fast turn-around time of such products. Driven by the growing biopharmaceutical pipeline, the need for efficient and faster process development and manufacturing solutions, the overall minibioreactors market and microbioreactors market is anticipated to witness steady growth in the coming years.

Scope of the Report

The ‘Mini Bioreactors and Micro Bioreactors Market, 2022-2035: Distribution by Type of Cell Culture (Mammalian, Microbial, Viral, Insect and Others), Mode of Operation (Batch/Fed-Batch and Continuous), End User (Biopharmaceutical Industry and Academic Institutes) and Key Geographical Regions (North America, Europe, Asia-Pacific, and Rest of the World): Industry Trends and Global Forecasts’ report features an extensive study of the current landscape and the likely future potential of minibioreactors and microbioreactors, over the next decade. The study also features an in-depth analysis, highlighting the capabilities of various industry stakeholders engaged in this field. In addition to other elements, the study includes:

  • A detailed assessment of the overall market landscape of minibioreactors and microbioreactors based on a number of relevant parameters, such as status of development, type of cell culture (mammalian, microbial, viral, insect and others), mode of operation (batch/fed-batch reactor and continuous reactor), typical working volume, weight of the bioreactor, stirrer speed, and other parameters controlled (dissolved oxygen, oxygen, carbon dioxide, pH, and temperature). In addition, it presents details of the companies manufacturing minibioreactors and microbioreactors, highlighting their year of establishment, size of employee base, and geographical presence.
  • Elaborate profiles of prominent players (shortlisted based on number of products being offered) engaged in the development of minibioreactors and microbioreactors. Each company profile features a brief overview of the company, along with information on year of establishment, number of employees, location of headquarters and key members of the executive team. It also includes details of their respective product portfolio, and recent developments and an informed future outlook.
  • A detailed competitiveness analysis of minibioreactors and microbioreactors, taking into consideration several relevant parameters, such as the working volume, stirrer speed, and mode of operation.
  • An in-depth analysis of over 250 patents that have been filed / granted for minibioreactors and microbioreactors, between 2016 and 2022 (till March), highlighting key trends associated with these patents, across type of patents, publication year, issuing authorities involved, emerging focus area, patent age, CPC symbols, leading patent assignees (in terms of number of patents granted / filed), patent characteristics and geography. It also includes a detailed patent benchmarking and an insightful valuation analysis. 

One of the key objectives of the report was to understand the primary growth drivers and estimate the future size of minibioreactors and microbioreactors market. Based on multiple parameters, such as overall biopharmaceutical manufacturing market, overall single-use bioreactors market, share of minibioreactors and microbioreactors technologies, and likely adoption trends, we have provided an informed estimate of the evolution of the market for the period 2022-2035. Our year-wise projections of the current and future opportunity have further been segmented on the basis of [A] type of cell culture (mammalian, microbial, viral, insect and others), [B] mode of operation (batch/fed-batch reactor and continuous reactor), [C] end-user (biopharmaceutical / pharmaceutical industries and academic / research institutes) and [D] key geographical regions (North America, Europe, Asia-Pacific and rest of the world). In order to account for future uncertainties and to add robustness to our model, we have provided a base forecast scenario to represent different tracks of the industry’s growth.

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

Key Questions Answered

  • Who are the leading manufacturers engaged in the development of minibioreactors and microbioreactors?
  • What are the different applications for which minibioreactors and microbioreactors are currently being used?
  • What are the challenges currently faced by stakeholders in minibioreactors and microbioreactors market?
  • What are the key factors that are likely to influence the evolution of minibioreactors and microbioreactors market?
  • How is the current and future opportunity likely to be distributed across key market segments?
  • What are the anticipated future trends related to minibioreactors and microbioreactors market?

Contents

Chapter Outlines

Chapter 2 is an executive summary of the key insights captured in our research. It offers a high-level view on the current state of the minibioreactors and microbioreactors market and its likely evolution in the short to mid-term and long term.

Chapter 3 provides a general introduction to minibioreactors and microbioreactors, covering details related to the current and future trends in the domain. Further, it includes a relation between process information and experimental output. The chapter also highlights the different types of minibioreactors and microbioreactors. In addition, it also elaborates on the current needs and advantages of minibioreactors and microbioreactors.

Chapter 4 includes information on over 55 minibioreactors and microbioreactors that are either commercialized or under development. It features detailed assessment of the overall market landscape of minibioreactors and microbioreactors based on a number of relevant parameters, status of development, type of cell culture (mammalian, microbial, viral, insect and others), mode of operation (batch/fed-batch reactor and continuous reactor), typical working volume, weight of the bioreactor, stirrer speed, and other parameters controlled (dissolved oxygen, oxygen, carbon dioxide, pH, and temperature). In addition, it presents details of the companies manufacturing minibioreactors and microbioreactors, highlighting their year of establishment, size of employee base, and geographical presence.
 
Chapter 5 features elaborate profiles of prominent players (shortlisted based on number of products being offered) engaged in the development of minibioreactors and microbioreactors. Each company profile features a brief overview of the company, along with information on year of establishment, number of employees, location of headquarters and key members of the executive team. It also includes details of their respective product portfolio, and recent developments and an informed future outlook.

Chapter 6 features an insightful three-dimensional bubble chart representation, highlighting the competitiveness analysis of minibioreactors and microbioreactors manufacturers, taking into consideration the supplier power (based on expertise of the manufacturer), and product strength.

Chapter 7 provides an in-depth patent analysis presenting an overview of how the industry is evolving from the R&D perspective. For this analysis, we considered of over 250 patents that have been filed / granted for minibioreactors and microbioreactors, between 2016 and 2022 (till February), highlighting key trends associated with these patents, across type of patents, publication year, issuing authorities involved, emerging focus area, patent age, CPC symbols, leading patent assignees (in terms of number of patents granted / filed), patent characteristics and geography. It also includes a detailed patent benchmarking and an insightful valuation analysis. 

Chapter 8 features an insightful market forecast analysis, highlighting the likely growth of the minibioreactors and microbioreactors market, for the time period 2022-2035. In order to provide details on the future outlook, our projections have been segmented on the basis of [A] type of cell culture (mammalian culture, microbial culture, viral culture, insect culture and other cell cultures), [B] mode of operation (batch/fed-batch reactor and continuous reactor), [C] end-user (biopharmaceutical / pharmaceutical industries and academic / research institutes), and [D] key geographical regions (North America, Europe, Asia-Pacific and rest of the world).  In order to account for future uncertainties and to add robustness to our model, we have provided a base forecast scenario to represent different tracks of the industry’s growth.

Chapter 9 presents a case study, based on a number of relevant parameters, such as scale of operation (lab, clinical and commercial), type of cell culture system (2D culture and 3D culture), type of cell culture (mammalian, insect, microbial, viral, plant and others), type of molecule (vaccine, monoclonal antibody, recombinant protein, stem cell, cell therapy, gene therapy and others), key features (touch screen, remote monitoring, build-in system control sensors, electronic log record, alarm system), application area (stem cell research, cancer research, regenerative medicine, drug discovery and others) and end users (pharma / biopharma, contract manufacturing organization, contract research organization and academic institutes). In addition, it presents details of the companies developing single-use bioreactors, highlighting their year of establishment, company size, and geographical presence.

Chapter 10 is a summary of the entire report. In this chapter, we have provided a list of key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.

Chapter 11 is an appendix, which provides tabulated data and numbers for all the figures provided in the report.

Chapter 12 is an appendix, which contains the list of companies and organizations mentioned in the report

Table Of Contents

1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Key Questions Answered
1.4. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION
3.1. Chapter Overview
3.2. Overview of Minibioreactors and Microbioreactors
3.2.1. Types of Minibioreactors and Microbioreactors

3.3. Advantages of Minibioreactors and Microbioreactors
3.4. Fabrication Materials for Minibioreactors and Microbioreactors
3.5. Future Perspectives

4. MARKET LANDSCAPE
4.1. Chapter Overview
4.2. Minibioreactors and Microbioreactors: Overall Market Landscape
4.2.1. Analysis by Minimum Working Volume
4.2.2. Analysis by Maximum Working Volume
4.2.3. Analysis by Stirrer Speed
4.2.4. Analysis by Mode of Operations
4.2.5. Analysis by Usability
4.2.6. Analysis by Parameters Controlled

4.3. Minibioreactors and Microbioreactors Manufacturers: List of Industry Players
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Company Size
4.3.3. Analysis by Location of Headquarters
4.3.4. Analysis by Year of Establishment and Company Sie
4.3.5. Leading Manufacturers: Analysis by Number of Products

5. COMPANY PROFILES
5.1. Chapter Overview

5.2. Eppendorf
5.2.1. Company Overview
5.2.2. Product Portfolio
5.2.3. Recent Developments and Future Outlook

5.3. Biosan
5.3.1. Company Overview
5.3.2. Product Portfolio
5.3.3. Recent Developments and Future Outlook

5.4. Bionet
5.4.1. Company Overview
5.4.2. Product Portfolio
5.4.3. Recent Developments and Future Outlook

5.5. Pall Corporation
5.5.1. Company Overview
5.5.2. Product Portfolio
5.5.3. Recent Developments and Future Outlook

5.6. Merck Millipore
5.6.1. Company Overview
5.6.2. Product Portfolio
5.6.3. Recent Developments and Future Outlook

5.7. Sartorius
5.7.1. Company Overview
5.7.2. Product Portfolio
5.7.3. Recent Developments and Future Outlook

5.8. Cytiva
5.8.1. Company Overview
5.8.2. Product Portfolio
5.8.3. Recent Developments and Future Outlook

5.9. Distek
5.9.1. Company Overview
5.9.2. Product Portfolio
5.9.3. Recent Developments and Future Outlook

6. PRODUCT COMPETITIVENESS ANALYSIS
6.1. Chapter Overview
6.2. Assumptions / Key Parameters
6.3. Methodology
6.4. Product Competitiveness Analysis: Minibioreactors and Microbioreactors

7. PATENT ANALYSIS
7.1. Chapter Overview
7.2. Scope and Methodology

7.3. Minibioreactors and Microbioreactors: Patent Analysis
7.3.1. Analysis by Type of Patent
7.3.2. Analysis by Patent Publication Year
7.3.3. Analysis by Patent Application Year
7.3.4. Analysis by Geographical Location
7.3.5. Analysis by CPC Symbols
7.3.6. Analysis by Type of Organization
7.3.7. Leading Industry Players: Analysis by Number of Patents
7.3.8. Leading Non-Industry Players: Analysis by Number of Patents
7.3.9. Leading Patent Assignees: Analysis by Number of Patents
7.3.10. Analysis by Patent Characteristics
7.3.11. Analysis by Patent Age
7.3.12. Patent Valuation Analysis

8. MARKET FORECAST
8.1. Chapter Overview
8.2. Forecast Methodology and Key Assumptions
8.3. Global Minibioreactors and Microbioreactors Market, 2022-2035

8.4. Global Minibioreactors and Microbioreactors Market: Distribution by Type of Cell Culture
8.4.1. Minibioreactors and Microbioreactors Market for Mammalian Culture, 2022-2035
8.4.2. Minibioreactors and Microbioreactors Market for Microbial Culture, 2022-2035
8.4.3. Minibioreactors and Microbioreactors Market for Viral Culture, 2022-2035
8.4.4. Minibioreactors and Microbioreactors Market for Insect Culture, 2022-2035
8.4.5. Minibioreactors and Microbioreactors Market for Other Cell Cultures, 2022-2035

8.5. Global Minibioreactors and Microbioreactors Market: Distribution by Mode of Operation
8.5.1. Minibioreactors and Microbioreactors Market for Batch/Fed-Batch Operations, 2022-2035
8.5.2. Minibioreactors and Microbioreactors Market for Continuous Operations, 2022-2035

8.6. Global Minibioreactors and Microbioreactors Market: Distribution by Key Geographical Regions
8.6.1. Minibioreactors and Microbioreactors Market in North America, 2022-2035
8.6.2 Minibioreactors and Microbioreactors Market in Europe, 2022-2035
8.6.3. Minibioreactors and Microbioreactors Market in Asia-Pacific, 2022-2035
8.6.4. Minibioreactors and Microbioreactors Market in Rest of the World, 2022-2035

8.7. Concluding Remarks

9. CASE STUDY: SINGLE-USE BIOREACTORS
9.1. Chapter Overview
9.2. Single-use Bioreactors: List of Products
9.2.1. Analysis by Type of Bioreactor
9.2.2. Analysis by Scale of Operation
9.2.3. Analysis by Type of Cell Culture System
9.2.4. Analysis by Type of Cell Culture
9.2.5. Analysis by Type of Molecule Processed
9.2.6. Analysis by Key Features
9.2.7. Analysis by Application Area
9.2.8. Analysis by End Users
9.2.9. Analysis by Working Volume

9.3. Single-use Bioreactors: Developer Landscape
9.3.1. Analysis by Year of Establishment
9.3.2. Analysis by Company Size
9.3.3. Leading Developers: Analysis by Number of Single-use Bioreactors
9.3.4. Analysis by Location of Headquarters

10. CONCLUSION

11. APPENDIX I: TABULATED DATA

12. APPENDIX II: LIST OF COMPANIES AND ORGANIZATIONS

List Of Figures

Figure 3.1 Bioreactors: Relation between Process Information and Experimental Output
Figure 3.2 Types of Minibioreactors
Figure 3.3 Advantages of Minibioreactors and Microbioreactors
Figure 4.1 Minibioreactors and Microbioreactors: Distribution by Minimum Working Volume
Figure 4.2 Minibioreactors and Microbioreactors: Distribution by Maximum Working Volume
Figure 4.3 Minibioreactors and Microbioreactors: Distribution by Speed of Stirrer
Figure 4.4 Minibioreactors and Microbioreactors: Distribution by Mode of Operation
Figure 4.5 Minibioreactors and Microbioreactors: Distribution by Usability
Figure 4.6 Minibioreactors and Microbioreactors: Distribution by Parameters Controlled
Figure 4.7 Minibioreactors and Microbioreactors Manufacturers: Distribution by Year of Establishment
Figure 4.8 Minibioreactors and Microbioreactors Manufacturers: Distribution by Company Size
Figure 4.9 Minibioreactors and Microbioreactors Manufacturers: Distribution by Location of Headquarters
Figure 4.10 Minibioreactors and Microbioreactors Manufacturers: Distribution by Year of Establishment and Company Size
Figure 4.11 Leading Manufacturers: Distribution by Number of Products
Figure 6.1 Product Competitiveness Analysis: Minibioreactors and Microbioreactors
Figure 7.1 Patent Analysis: Distribution by Type of Patent
Figure 7.2 Patent Analysis: Cumulative Distribution by Publication Year, 2016-2022 (till February)
Figure 7.3 Patent Analysis: Cumulative Distribution by Application Year, 2016-2022 (till February)
Figure 7.4 Patent Analysis: Distribution by Geographical Location
Figure 7.5 Patent Analysis: Distribution by CPC Symbols
Figure 7.6. Patent Analysis: Cumulative Year-wise Distribution by Type of Organization
Figure 7.7 Leading Industry Players: Distribution by Number of Patents
Figure 7.8 Leading Non-Industry Players: Distribution by Number of Patents
Figure 7.9 Patent Analysis: Leading Individual Assignees
Figure 7.10 Patent Analysis (Leading Industry Players): Benchmarking by Patent Characteristics (CPC Symbols)
Figure 7.11 Patent Analysis: Distribution of Patents by Age (2016-2022)
Figure 7.12 Minibioreactors and Microbioreactors: Patent Valuation Analysis
Figure 8.1 Global Minibioreactors and Microbioreactors Market, 2022-2035 (USD Million)
Figure 8.2 Global Minibioreactors and Microbioreactors Market: Distribution by Type of Equipment, 2022 and 2035 (USD Million)
Figure 8.3 Global Minibioreactors Market, 2022-2035 (USD Million)
Figure 8.4 Global Microbioreactors Market, 2022-2035 (USD Million)
Figure 8.5 Global Minibioreactors and Microbioreactors Market: Distribution by Mode of Operation, 2022-2035 (USD Million)
Figure 8.6 Minibioreactors and Microbioreactors Market for Continuous Reactor, 2022-2035 (USD Million)
Figure 8.7 Minibioreactors and Microbioreactors Market for Batch/Fed-Batch Reactor, 2022-2035 (USD Million)
Figure 8.8 Global Minibioreactors and Microbioreactors Market: Distribution by Geography, 2022 and 2035 (USD Million)
Figure 8.9 Minibioreactors and Microbioreactors Market in North America, 2022-2035 (USD Million)
Figure 8.10 Minibioreactors and Microbioreactors Market in Europe, 2022-2035 (USD Million)
Figure 8.11 Minibioreactors and Microbioreactors Market in Asia-Pacific, 2022-2035 (USD Million)
Figure 8.12 Minibioreactors and Microbioreactors Market in Rest of the World, 2022-2035 (USD Million)
Figure 9.1 Single-Use Bioreactors: Distribution by Status of Development
Figure 9.2 Single-Use Bioreactors: Distribution by Type of Single-Use Bioreactor
Figure 9.3 Single-Use Bioreactors: Distribution by Scale of Operation
Figure 9.4 Single-Use Bioreactors: Distribution by Area of Application
Figure 9.5 Single-Use Bioreactors: Distribution by Working Volume
Figure 9.6 Single-Use Bioreactors: Distribution by Type of Cell Culture Handled
Figure 9.7 Single-Use Bioreactors: Distribution by Type of Molecule
Figure 9.8 Single-Use Bioreactor Developers: Distribution by Year of Establishment
Figure 9.9 Single-Use Bioreactor Developers: Distribution by Company Size
Figure 9.10 Single-Use Bioreactor Developers: Distribution by Location of Headquarters
Figure 9.11 Leading Manufacturers: Distribution by Number of Products

List Of Tables

Table 3.1 Fabrication Materials for Minibioreactors and Microbioreactors
Table 4.1 Minibioreactors and Microbioreactors: Information on Total Volume, Stirrer Speed, Mode of Operation and Usability
Table 4.2 Minibioreactors and Microbioreactors: Information on Parameters Controlled
Table 4.3 Minibioreactors and Microbioreactors: List of Manufacturers
Table 5.1 Minibioreactors and Microbioreactors: List of Companies Profiled
Table 5.2 BIONET: Company Snapshot
Table 5.3 BIONET: Product Portfolio
Table 5.4 Biosan: Company Snapshot
Table 5.5 Biosan: Product Portfolio
Table 5.6 Cytiva: Company Snapshot
Table 5.7 Cytiva: Product Portfolio
Table 5.8 Distek: Company Snapshot
Table 5.9 Distek: Product Portfolio
Table 5.10 Eppendorf: Company Snapshot
Table 5.11 Eppendorf: Product Portfolio
Table 5.12 Eppendorf: Recent Developments and Future Outlook
Table 5.13 Merck Millipore: Company Snapshot
Table 5.14 Merck Millipore: Product Portfolio
Table 5.15 Merck Millipore: Recent Developments and Future Outlook
Table 5.16 Pall Corporation: Company Snapshot
Table 5.17 Pall Corporation: Product Portfolio
Table 5.18 Pall Corporation: Recent Developments and Future Outlook
Table 5.19 Sartorius: Company Snapshot
Table 5.20 Sartorius: Product Portfolio
Table 5.21 Sartorius: Recent Developments and Future Outlook
Table 7.1 Patent Analysis: Prominent CPC Symbols
Table 7.2 Patent Analysis: Categorization based on Weighted Valuation Scores
Table 9.1 Single-Use Bioreactors: Information on Scale of Operation
Table 9.2 Single-Use Bioreactors: Information on Type of Bioreactor
Table 9.3 Single-Use Bioreactors: Information on Type of Cell Culture System
Table 9.4 Single-Use Bioreactors: List of Manufacturers

List Of Companies

The following companies and organizations have been mentioned in the report:

  1. ABLE Corporation & Biott
  2. Agency for Science, Technology and Research (A*STAR)  
  3. Alector
  4. BASF
  5. bbi-biotech
  6. BioGaia
  7. BIONET   
  8. Biosan
  9. Boehringer Ingelheim
  10. Borg Scientific
  11. Cellexus
  12. CESCO Bioengineering
  13. Conagen
  14. Cytiva
  15. Distek
  16. Donaldson 
  17. Duke University
  18. Eppendorf
  19. Esco VacciXcell (a subsidiary of Esco LifeSciences)
  20. Getinge
  21. H.E.L Group   
  22. Harvard College
  23. Infors HT 
  24. Johns Hopkins University
  25. Lambda
  26. Leland Stanford Junior University
  27. Massachusetts Institute of Technology (MIT)
  28. Merck Millipore
  29. Novozymes
  30. Pall Corporation
  31. PBS Biotech
  32. PlateletBio
  33. Premas Biotech
  34. Roch Mechatronics
  35. Refine Technology
  36. Roche
  37. Sanofi
  38. Sartorius
  39. Solida Biotech
  40. Stämm Biotech
  41. Technical University of Denmark
  42. The Automation Partnership (Cambridge)
  43. The University of British Columbia
  44. The University of Queensland
  45. University of California
  46. University of Maryland
  47. Vanderbilt University

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