Molecular Switches

Molecular Switches: Intellectual Property Landscape (Featuring Historical and Contemporary Patent Filing Trends, Prior Art Search Expressions, Patent Valuation Analysis, Patentability, Freedom to Operate, Pockets of Innovation, Existing White Spaces, and Claim Analysis)

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Report Description

Attempts to synthetically recreate the biological circuits in human body is a relatively new area of research within synthetic biology. Ever since the 2010s, the use of molecular “toggle” switches to mimic electronic circuits has been prevalent to understand, alter, and recreate molecular circuits within the human body. The evolution of chemistry and synthetic biology has reached an interesting point as these complex processes, including genetic regulation, expression, and replication are being understood at a molecular level. The prominent elements of these exploratory studies are molecular switches, which are responsive to internal or external stimuli and can be manipulated to create a transition between two stable states when exposed to a change in their optical, electrical, or chemical environment. During the past few years, several molecules have been identified and characterized as “switches”, which are now available for the construction of complex synthetic signaling networks with applications in both biology and nanotechnology. Of the different types of molecules, organic molecules, including proteins, nucleic acids, and cyclic organic compounds, such as crown ethers are likely to be the promising candidates in this field due to their diverse structural, electrical, and mechanical properties. In addition, synthetic molecules, such as Rotaxanes and Catenanes have emerged as potential molecular switches, as the binding sites within these mechanically interlocked molecules can be manipulated upon the application of stimuli, resulting in a shift in their structure and chemistry on cue.

One of the most important applications of molecular switches is to combat the challenges associated with anticancer therapies, like system toxicity, multidrug resistance, poor solubility, and membrane permeability. In order to overcome these drawbacks, researchers have undertaken several R&D efforts for identifying and developing effective treatment modalities. Among other alternatives, the use of Nanocarriers has emerged as a viable option. These nanomaterials encapsulate the drug, essentially warding it off from the surrounding physiological conditions and minimizing the side effects. Upon installation of molecular switches in their structure, these nanocarriers can be manipulated to gravitate towards a specific environment within the body and release the drug, when stimulated. The stimulus can further be manipulated to obtain the desired dosage strength and frequency. The extent of modification in these molecules allows for the use of minute differences in the biochemistry of different tissues as stimuli for targeted delivery of drugs. Simultaneously, with constant evolution in biomedical research and other emerging fields, such as optogenetics, molecular switches are being explored to directly switch the genes “on” and “off”, leading to control over genetic regulation and expression. The potential of gaining control over the molecular architecture and consequently, molecular function has led to a steady increase in the research and entrepreneurial activity in this domain. As a result, the intellectual capital around compositions of molecular switches, engineering techniques, and their application in gene regulation and therapeutic use, has also grown. In light of such developments, it is important to keep track of both pockets of innovation and key areas of improvement for stakeholders to remain competitive in this upcoming field of medicine / drugs. This report captures some of the key R&D-related trends and provides competitive intelligence on intellectual property in the field of molecular switches.

Scope of the Report

The “Molecular Switches: Intellectual Property Landscape” report features an extensive study of some of the key historical and contemporary intellectual property (IP) documents (featuring granted patents, patent applications and other documents), describing the various types of molecular switch interventions intended to treat a growing range of clinical conditions. The insights generated in this report have been presented across two deliverables, namely a MS Excel workbook and a MS PowerPoint deck, summarizing the ongoing activity in this domain. Key inclusions are briefly described below:

  • Overall Intellectual Property Landscape

An analytical perspective of the various patents and affiliated IP documents that have been published related to molecular switches, since 1981. An in-depth analysis of published IP documents, representing unique patent families across various global jurisdictions, featuring insightful inferences related to both historical and recent R&D trends within this niche, but rapidly evolving applications in the biotechnology and pharmaceutical industry.

  • Popular / Relevant Prior Art Search Expressions

An examination of IP literature, shortlisting key words and phrases used to describe molecular switches (and affiliated products) that are either already available in the market, or under development. The analysis also includes details on the historical use of the aforementioned terms across different IP filings, key affiliated terms (which can be used to identify other relevant IP search terms and establish relationships between prior art search expressions), and other related trends.

  • Patent Valuation Analysis

A competitive benchmarking and valuation analysis of the key members of unique patent families captured in the report, taking into consideration important parameters, such as type of IP document, year of application, time to expiry, number of citations and jurisdiction (factoring in value associated with the gross domestic product (GDP) of a particular region).

  • Patentability and Freedom to Operate

A systematic approach to identifying relevant areas of innovation by analyzing published IP documents (representative of unique patent families), by defining the uniqueness of patented / patent pending innovations, in order to assess the scope of patentability in this domain, and pinpoint jurisdictions wherein new and / or modified claims may be filed without infringing on existing IP. 

  • Analysis of Patent Applications

A detailed summary of the various patent applications (representative of unique patent families) that were filed across different jurisdictions and their relative value in the IP ecosystem. The analysis classified the intellectual capital in terms of type of innovation and the  innovation (such as a product class, enabling technologies or method of use), thereby, offering the means to identify active arenas of research and assess innovation-specific IP filing trends.

  • Analysis of Granted Patents

An analysis of the granted patents (representative of unique patent families) across different global jurisdictions and their relative value in the IP ecosystem. The analysis also features a meaningful classification system, segregating granted IP into relevant categories (namely type of innovation and innovation) to help develop a detailed perspective on the diversity of intellectual capital (having marketing exclusivity) related to molecular switches, and the assessing likelihood for innovators to enter into promising research areas. 

  • Pockets of Innovation and White Spaces

An insightful analysis of the various CPC codes used in published IP literature (representative of unique patent families) and their affiliated families, offering the means to identify historical and existing pockets of innovation (based on the functional area / industry described by the elaborate and systematic IP classification approach, mentioned earlier); the analysis also features a discussion on prevalent white spaces (based on type of innovation and innovation) in this field of research.

  • Claim Analysis

One of the objectives of the report was to analyze and summarize key inferences from the independent claims mentioned in granted, active patents (representative of unique patent families) in the dataset. Using a systematic segregation approach, we have analyzed trends associated with the preamble, type of patent (product patent or method patent), type of claim (open ended claim or closed ended claim) and key elements of a claim (individual aspects of an innovation that are covered in a singular claim).

Contents

DELIVERABLE OUTLINES

Excel Deliverable

Sheet 1 features details regarding how the input data for this project was collated, including the search strings used to query a popular, public patent database (namely lens.org), and data segregation notes. 

Sheet 2 is a summary MS Excel dashboard, offering a detailed, graphical perspective of the intellectual property landscape of molecular switches. It includes pictorial representations of the [A] overall patent landscape, [B] IP documents representing patent families that describe unique innovations related to molecular switches, [C] trends related to patent applications (including insights on patentability and freedom to operate), [D] trends related to granted patents (including insights on patentability and freedom to operate), [E] key inferences from a proprietary claim analysis, [F] list of popular CPC symbols (featuring key pockets of innovation), [G] list of popular applicants (shortlisted based on number of published IP documents).
    
Sheet 3 is an elaborate tabular representation of the overall IP landscape, featuring information on the various types of IP documents, related to molecular switches, which have been published since 1981. 

Sheet 4 is an excerpt of the data presented in the previous sheet, featuring published IP documents, that represent unique patent families across various global jurisdictions. This dataset has been analyzed in detail, in the report. 

Sheet 5 includes a tabular representation of the key words and phrases (prior art search expressions) that are used to describe molecular switches and affiliated intellectual capital.

Sheet 6 is a subset of sheet 4, featuring all the patent applications, covering innovations related to molecular switches and affiliated methods, compositions and engineering techniques.

Sheet 7 is a subset of sheet 4, featuring all the granted patents, covering innovations related to molecular switches and affiliated methods / products. 

Sheet 8 is an insightful summary of key inferences from the independent claims of the granted, active patents in the dataset. It involves the use of a systematic segregation approach to analyze key trends associated with the preamble, type of patent (product patent or method patent), type of claim (open ended claim or closed ended claim) and key elements of a claim (individual aspects of an innovation that are covered in a singular claim).

Sheet 9 provides insights related to some of the key applicants that are active in this field of research, featuring company-specific details (such as year of establishment, and location of headquarters), and inputs on their respective IP publication trends. 
    
Sheet 10 features an analysis of the most popular CPC symbols and CPC families (in terms of frequency of appearance in the dataset), related to molecular switches that are either already available in the market, or under development. 

Sheet 11 is an appendix, which includes pivot tables that drive the charts and interactive elements for the complete IP landscape depicted in sheet 2 of the deliverable.

Sheet 12 is an appendix, featuring details related to the categorization done in the report, and important abbreviations used in reference to the data categories mentioned in the document. 

PowerPoint Deliverable
Chapter 1
briefly describes of the need for molecular switches interventions and the key advantages associated with the use of such molecular switches. Further, it provides an overview of the intellectual property landscape related to this niche class of synthetic biology research. 

Chapter 2 and 3 feature brief (pictorial) summaries of the approach used during data collection for this project, and the key objectives of the study.

Chapter 4 is an executive summary of the important insights and key takeaways, generated from analyzing the IP landscape of molecular switches.

Chapter 5 offers an informed perspective on the core concepts of molecular switches. It also includes brief descriptions of molecular switches that are available and under development, elaborating on the contemporary need for such therapeutic and diagnostic solutions. Further, it provides a summary of the important milestones in this field of research, highlighting some of the distinguishing features of both early generation and modern variants of such interventions. The chapter also includes a description of important application areas of molecular switches, highlighting the various advantages and existing limitations of molecular switches.

Chapter 6 includes a review of the various patents and affiliated IP documents that have been published related to molecular switches, since the year 1981. It also features an in-depth analysis of published IP documents, representing unique patent families across various global jurisdictions, and includes insightful inferences related to both historical and recent R&D trends within this niche, but rapidly evolving applications the healthcare segment.

Chapter 7 features an insightful examination of IP literature, highlighting key words and phrases that are used to describe different molecular switches, including information on historical usage in IP filings, key affiliated terms (which can be used to identify other relevant IP search terms and establish relationships between prior art search expressions), and other related trends.

Chapter 8 offers insights from a competitive benchmarking and valuation analysis of the key members of unique patent families that have been captured in the report. It takes into consideration important parameters, such as type of IP document, year of application, time to expiry, number of citations and jurisdiction (factoring in value associated with the gross domestic product (GDP) of a particular region).

Chapter 9 provides a detailed summary of the patent applications (representative of unique patent families) that were filed across different jurisdictions and their relative value in the IP ecosystem. The analysis segregates the captured intellectual capital in terms of type of innovation and the specific innovation (different product classes, enabling technologies or methods of use), thereby, offering the means to identify active arenas of research and assess innovation-specific IP filing trends. Further, it features an analysis that helps identify relevant areas of innovation by analyzing published IP documents (representative of unique patent families), defining the uniqueness of patent pending innovations, in order to assess the scope of patentability in this domain, and pinpoint jurisdictions where new and / or modified claims may be filed without infringing on existing IP.

Chapter 10 is an elaborate summary of the granted patents (representative of unique patent families) across different global jurisdictions and their relative value in the IP ecosystem. The analysis also features a meaningful classification system, segregating granted IP into relevant categories (namely type of innovation and innovation) to help develop a detailed perspective on the diversity of intellectual capital (having marketing exclusivity) related to molecular switches, and assessing the likelihood for innovators to enter into promising product markets, once active patents expire. Further, it features an analysis that helps identify relevant areas of innovation by analyzing published IP documents (representative of unique patent families), defining the uniqueness of patented innovations, in order to assess the scope of patentability in this domain, and pinpoint jurisdictions where new and / or modified claims may be filed without infringing on existing IP.

Chapter 11 features profiles of some of the most popular applicant companies, which were shortlisted based on their respective patent filing activities. Each profiles includes a brief overview of the company, information on annual revenues (wherever available), details on its molecular switch related initiatives, names of key management team members and recent developments. 

Chapter 12 includes an insightful analysis of the various CPC symbols mentioned in published IP literature (representative of unique patent families) and their affiliated families, offering the means to identify historical and existing pockets of innovation (based on the functional area / industry described by the elaborate and systematic IP classification approach, mentioned earlier); the analysis also features a discussion on prevalent white spaces (based on innovation and innovation types) in this field of research.

Chapter 13 concludes the report by summarizing publicly available insights on the anticipated developments in this domain (taking into consideration the perspectives of eminent representatives of stakeholder companies in this industry), and trends that are likely to shape the future of molecular switches. 

Chapter 14 is a set of appendices, entailing [A] an overview of the excel research report, [B] a list of IP documents featuring the identified white spaces, [C] table of contents, [D] list of figures, [E] list of tables, [F] glossary, and [G] list of all the applicant companies and organizations.

Table Of Contents

Excel Deliverable

1. Research Notes

2. Summary Dashboard
A. Overall Intellectual Property Landscape
B. Intellectual Property Landscape (Grouped by Simple Families)
C. Key Prior Art Search Expressions
D. Key Trends related to Patent Applications (featuring Patentability and Freedom-to-Operate)
E. Key Trends related to Granted Patents (featuring Patentability and Freedom-to-Operate)

F. Claim Analysis
G. Key CPC Symbols
H. Key Applicants

3. Overall Intellectual Property Landscape Dataset

4. Prior Art Search Expressions (Keyword Analysis)

5. Patent Applications Dataset

6. Granted Patents Dataset

7. Claim Analysis

8. Key Applicants Analysis

9. CPC Analysis

10. Appendix I: Pivot Tables

11. Appendix II: Country / Geography Codes

12. Appendix III: Innovation Categories

PowerPoint Deliverable

1. Context

2. Project Approach

3. Project Objectives

4. Executive Summary

5. Molecular switches
5.1. Overview
5.2. Molecules Acting as Molecular Switches
5.3. Applications of Molecular Switches in Healthcare
5.4. Key Advantages and Limitations

6. Overall Intellectual Property Landscape
6.1. Overview
6.2. Analysis of Simple Patent Families
6.3. Key Innovation Categories
6.4. Insights from Patent Applications
6.5. Insights from Granted Patents

7. Key Prior Art Search Expressions
7.1. Overview
7.2. Analysis of Prior Art Search Expressions

8. Intellectual Property Valuation Analysis
8.1. Valuation Overview
8.2. Analysis of Individual Value Ranks
8.2.1. Rank 1 IP Documents
8.2.2. Rank 2 IP Documents
8.2.3. Rank 3 IP Documents
8.2.4. Rank 4 IP Documents
8.2.5. Rank 5 IP Documents
8.3. Concluding Remarks
8.4. List of Rank 1 IP Documents

9. Analysis of Patent Applications
9.1. Overview
9.2. Relative Valuation of Patent Applications
9.3. Patentability & Freedom-to-Operate

10. Analysis of Granted Patents
10.1. Overview
10.2. Relative Valuation of Grated Patents
10.3. Patentability & Freedom-to-Operate
10.4. Analysis of Patent Claims (Granted Active Patents)

11. Key Applicants
11.1. Overview
11.2. Analysis of Key Applicants
11.2.1. Company A
11.2.2. Company B
11.2.3. Company C
11.2.4. Company D
11.2.5. Company E
11.2.6. Company F
11.2.7. Company G
11.2.8. Company H
11.2.9. Company I
11.2.10. Company J

12. Pockets of Innovation and White Spaces
12.1. Overview
12.2. Pockets of Innovation
12.3. White Spaces
12.4. Concluding Remarks

13. Future Outlook
13.1. Molecular Switches: IP Filing Growth Trends
13.2. Relevance of IP for Business Development and Growth
13.3. Contemporary Sentiments and Predictions
13.4 Anticipated Future Developments and Trends

14. Appendices

List Of Companies

The following companies / institutes / government bodies and organizations have been mentioned in this report

  1. 13therapeutics
  2. 149 Bio
  3. 2seventy bio
  4. 3M
  5. A2 Biotherapeutics
  6. Aarhus University
  7. AB Biosciences
  8. Ab Studio
  9. Abbott Laboratories
  10. AbbVie
  11. Accutar Biotech
  12. Aclara Biosciences
  13. Activartis Biotech
  14. Advanced Microbial
  15. AdVec
  16. Advisys
  17. AdynXX
  18. Aeomica
  19. Affigen
  20. Agency for Science, Technology and Research
  21. Agensys
  22. Agilent Technologies
  23. AIIMS - All India Institute Of Medical Science
  24. Aix-Marseille University
  25. Alastin Skincare
  26. Albert Einstein College of Medicine
  27. Alcatel-Lucent Enterprise
  28. Alder BioPharmaceuticals
  29. Alector
  30. Alize Pharma
  31. Allergan
  32. Allinaire Therapeutics
  33. alliumvitalis
  34. Alpha Beta Holdings
  35. Ambion
  36. Amgen
  37. Amicus Therapeutics
  38. Anacor Pharmaceuticals
  39. Anhui University of Science and Technology
  40. Antengene Corporation
  41. Applera
  42. Applied Genetics Laboratories
  43. AptaBharat
  44. AptaScan
  45. Araxes Pharma
  46. Arbor Biotechnologies
  47. Archemix
  48. Arena Pharmaceuticals
  49. ARIAD Pharmaceuticals
  50. Aridis Pharmaceuticals
  51. ArQule
  52. Array BioPharma
  53. Asahi Kasei
  54. Ascentage Pharma
  55. Asklepios BioPharmaceutical
  56. ASML
  57. Assistance Publique–Hôpitaux de Paris
  58. Asterias Biotherapeutics
  59. Aston University
  60. AstraZeneca
  61. Athenex
  62. Auburn University
  63. Augusta University Research Institute
  64. Autolus
  65. Aventis Pharma
  66. AVEO Pharmaceuticals
  67. Avid Bioservices
  68. Avigen
  69. Axaron Bioscience
  70. Axiogenesis
  71. Axordia
  72. Azeria Therapeutics
  73. Azitra
  74. Babraham Institute
  75. Bach Pharma
  76. Baker Hughes
  77. Bar-Ilan University
  78. BASF
  79. Bayer
  80. Baylor College of Medicine
  81. Beida Pharmaceutical Industry
  82. Beijing University of Chemical Technology
  83. Beijing Xuanyi Pharmasciences
  84. Bellastem
  85. Bellicum Pharmaceuticals
  86. Ben-Gurion University of the Negev
  87. BERG
  88. Beth Israel Deaconess Medical Center
  89. BioActa
  90. BIOalternatives
  91. Biogen
  92. Bio-Gene Technologies
  93. BioGlow
  94. BioNTech
  95. Bioquest
  96. BioSante Pharmaceuticals
  97. Biotheryx
  98. Biotraces
  99. BioZyme
  100. Bluebird bio
  101. Bond Pet Foods
  102. Boston Biomedical
  103. Boston Biomedical Research Institute
  104. Boston Medical Center
  105. Boston Probes
  106. Boston Scientific Scimed
  107. Boston University
  108. Brandeis University
  109. Breast Cancer Now
  110. Bridge Pharma
  111. Bridgestone
  112. Brigham and Women's Hospital
  113. Brilliant Lab
  114. Bristol Myers Squibb
  115. Broad Institute
  116. Brookhaven Science Associates
  117. Brown University
  118. Buck Institute for Research on Aging
  119. Cadus Pharmaceutical
  120. Cadus Technologies
  121. California Institute of Technology
  122. California State University, Northridge
  123. Caliper Life Sciences
  124. Cambridge Scientific
  125. Cambridge University
  126. Cancer Research Technology
  127. Canji
  128. Cara Therapeutics
  129. Cardax Pharmaceuticals
  130. Cardiff University
  131. CareDx
  132. Caribou Biosciences
  133. Carmel
  134. Cartesian Therapeutics
  135. Cartherics
  136. CASCADE BIOSYSTEMS
  137. Case Western Reserve University
  138. Catalan Institution for Research and Advanced Studies
  139. Catalyst Therapeutics
  140. Cathay Biotech
  141. Cava Healthcare
  142. Cedars-Sinai Medical Center
  143. Celdara Medical
  144. Celgene
  145. Cell Genesys
  146. Cell Signaling Technology
  147. Cellectis
  148. Cellex
  149. Cellular Biomedicine Group
  150. Cemvita Factory
  151. Center for Human Reproduction
  152. Centocor
  153. Centre for Drug Research and Development
  154. Centre hospitalier de l'Université de Montréal
  155. Chesapeake Perl
  156. Children’s Medical Center Dallas
  157. Children's Healthcare of Atlanta
  158. Children's Hospital of Philadelphia
  159. Children's National Hospital
  160. China Medical University
  161. China Pharmaceutical University
  162. Chinese University of Hong Kong
  163. Chisso
  164. Chosun University
  165. ChromaCon
  166. Chugai Pharmaceutical
  167. Ciba Corning Diagnostics
  168. Citranvi Biosciences
  169. Cleveland State University
  170. CNIC
  171. CNRS
  172. Cochlear
  173. CODA Biotherapeutics
  174. Cognosci
  175. Cold Spring Harbor Laboratory
  176. Columbia University
  177. Commonwealth System of Higher Education
  178. Connecticut Children's Medical Center
  179. Contour Semiconductor
  180. Cornell University
  181. Council of Scientific and Industrial Research
  182. Creative Biomolecules
  183. CropDesign
  184. Crossbar
  185. CrossLife Technologies
  186. CSPC Dophen
  187. CuraGen
  188. Cure Genetics
  189. Curemark
  190. Curie Institute
  191. CZ Biohub
  192. Dade Behring Marburg
  193. Daiichi Sankyo
  194. DAKO
  195. Dalian Institute of Chemical Physics
  196. Dana Farber Cancer Institute
  197. Dana-Farber Cancer Institute
  198. Dana–Farber Cancer Institute
  199. Danisco
  200. Dart NeuroScience
  201. Dartmouth College
  202. deCODE genetics
  203. Dendreon Pharmaceuticals
  204. Department of Biotechnology
  205. Diabetes Free
  206. DONGJIN SEMICHEM
  207. Draper Laboratory
  208. Drexel University
  209. Duke University
  210. DuPont
  211. East Carolina University
  212. East China Normal University
  213. Eastern Michigan University
  214. Eastern Virginia Medical School
  215. Ecole Polytechnique Fédérale de Lausanne
  216. Edge Therapeutics
  217. Edimer Pharmaceuticals
  218. eFFECTOR Therapeutics
  219. Eindhoven University of Technology
  220. EiRx Therapeutics
  221. Electrophoretics
  222. Eleszto Genetika
  223. EMD Serono
  224. Emory University
  225. Empire Dev
  226. Encyt Technologies
  227. Environmental Technologies Group
  228. ESPCI Paris
  229. Eureka Therapeutics
  230. European Molecular Biology Laboratory
  231. Exelixis
  232. EXiBONA
  233. ExxonMobil Chemical
  234. Fate Therapeutics
  235. Feinstein Institutes for Medical Research
  236. Five Prime Therapeutics
  237. Flagship Pioneering
  238. Florida State University
  239. FormFactor
  240. Fosun Pharma
  241. Fovea Pharmaceuticals
  242. Fox Chase Cancer Center
  243. Frankgen Biotechnologie
  244. Fred Hutchinson Cancer Research Center
  245. French Alternative Energies and Atomic Energy Commission
  246. French National Centre for Scientific Research
  247. Fudan University
  248. Fuji Biomedix
  249. Fuji Electric
  250. Fuji Xerox
  251. Fujian Normal Universit
  252. Fujifilm Cellular Dynamics
  253. Galactica Pharmaceuticals
  254. GALENAGEN
  255. GalPharma
  256. Gamida Cell
  257. GemVax & KAEL
  258. Gen-9
  259. Genagon Therapeutics
  260. GENEART
  261. Genelabs Technologies
  262. GeneMedicine
  263. Genentech
  264. General Electric
  265. Generation Bio
  266. Genesky Diagnostics
  267. Geneswitch Innovations
  268. GeneTAG Technology
  269. Genethon
  270. Geneyus
  271. GenFleet Therapeutics
  272. Geniatech
  273. Genizon BioSciences
  274. Genome Therapeutics
  275. GenPath Pharmaceuticals
  276. Gen-Probe
  277. Genzyme
  278. Georgetown University
  279. Georgia Regents University
  280. Geron
  281. Gevo
  282. Ghent University
  283. GigaGen
  284. Gladstone Institutes
  285. Gloriana Therapeutics
  286. Gorilla Genomics
  287. GPB Scientific
  288. GPC Biotech
  289. Gracell Biotechnologies
  290. GreenVenus
  291. Grenoble Alpes University
  292. GSK
  293. Guangdong Institute of Eco-environmental and Soil Sciences
  294. Guangzhou Institute of Biomedicine and Health
  295. Guilin Medical University
  296. Gwangju Institute of Science and Technology
  297. H. Lee Moffitt Cancer Center & Research Institute
  298. Hackensack University Medical Center
  299. Hadasit Medical Research Services & Development
  300. Hangzhou Clongene Biotech
  301. Hangzhou Jiuyuan Gene Engineering
  302. Harbin Veterinary Research Institute
  303. Harbor Therapeutics
  304. Harpoon Therapeutics
  305. Harvard College
  306. Health Research
  307. Helix BioPharma
  308. Henry Ford Health
  309. HEWLETT PACKARD
  310. Hisamitsu Pharmaceutical
  311. Hokkaido University
  312. Hong Kong University of Science and Technology
  313. Hrain Biotechnology
  314. Huaihai Institute of Technology
  315. Huazhong Agricultural University
  316. Huazhong University of Science and Technology
  317. Human Genome Sciences
  318. Hunan University
  319. Hunan Essence Biotech
  320. IBM
  321. Icahn School of Medicine at Mount Sinai
  322. iCell Gene Therapeutics
  323. IDEXX Laboratories
  324. ILIAS Biologics
  325. IMDEA Nanociencia
  326. Imiplex
  327. Immetacyte
  328. Immune Disease Institute
  329. ImmuNext
  330. Immunolight
  331. Imperial College London
  332. Incyte
  333. Indiana University
  334. Inhibrx
  335. Innate Pharma
  336. InnoCare Pharma
  337. Innovative Targeting Solutions
  338. Inovio Pharmaceuticals
  339. Inserm
  340. Institut Paoli-Calmettes
  341. Institut Pasteur of Shanghai, CAS
  342. Institute Claudius Regaud
  343. Institute of Biophysics
  344. Institute of Cancer Research
  345. Institute of Pharmacology of the Polish Academy of Sciences
  346. Intelligent Medical Devices
  347. Intocell
  348. Intra-Cellular Therapies
  349. Intrexon
  350. Invitrogen
  351. IO Biosciences
  352. iOmx Therapeutics
  353. IONTAS
  354. Ipsen
  355. IRM
  356. IrsiCaixa
  357. Isis Pharmaceuticals
  358. Jackson Laboratory
  359. Jacobio Pharmaceuticals
  360. Janssen Pharmaceuticals
  361. Japan Science and Technology Agency
  362. Javelin Oncology
  363. Jawaharlal Nehru Centre for Advanced Scientific Research
  364. Jiangnan University
  365. Jiangsu Police Institute
  366. Jiangxi University of Science and Technology
  367. Jilin University
  368. Jinan University
  369. Johns Hopkins University School of Medicine 
  370. Johnson & Johnson
  371. Joslin Diabetes Center
  372. Jubilant Biosys
  373. Julius Maximilian University of Würzburg
  374. Juno Therapeutics
  375. Kagawa University
  376. Kaiima
  377. Kansas State University
  378. Kazusa DNA Research Institute
  379. Keio University
  380. Kent State University
  381. Kindai University
  382. Kinex Pharmaceuticals
  383. King Abdulaziz City for Science and Technology
  384. King Abdulaziz University
  385. King's College London
  386. Kira Pharmaceuticals
  387. Kiromic
  388. Kite Pharma
  389. Knoll
  390. Knowmtech
  391. K?chi University
  392. Konica Minolta
  393. Korea Institute of Science and Technology
  394. Korea Research Institute of Bioscience and Biotechnology
  395. KSQ Therapeutics
  396. KU Leuven
  397. Kumho Petrochemical
  398. Kumquat Biosciences
  399. Kunming Institute of Botany
  400. KWS Saat
  401. Kymab
  402. Kyowa Hakko Kirin
  403. La Jolla Institute for Immunology
  404. LabyRx Immunologic Therapeutics
  405. Larix Bioscience
  406. LECTEC
  407. Leiden University Medical Center
  408. Leidos Biomedical Research
  409. Lek Pharmaceuticals
  410. Lentigen Technology
  411. LG Chem
  412. Life Technologies
  413. London Metropolitan University
  414. Los Alamos National Security
  415. Louisiana State University
  416. Lubris BioPharma
  417. Lucent
  418. Lucidicor
  419. Ludwig Cancer Research
  420. Lund University
  421. Lundbeck
  422. Lyell Immunopharma
  423. MacroGenics
  424. Maine Medical Center Research Institute
  425. Marquette University
  426. Martin Luther University of Halle-Wittenberg
  427. Massachusetts Eye and Ear
  428. Massachusetts General Hospital
  429. Massachusetts Institute of Technology
  430. Max Delbrück Center for Molecular Medicine in the Helmholtz Association
  431. Max Planck Society
  432. Maxim Pharmaceuticals
  433. Mayo Clinic
  434. McGill University
  435. McMaster University
  436. Medannex
  437. Medical College of Georgia
  438. Medical Research Council
  439. Medigene
  440. MedImmune
  441. MediQuest Therapeutics
  442. Medisix Therapeutics
  443. Medvet Science
  444. Memorial Sloan Kettering Cancer Center
  445. Merck
  446. Merical
  447. Meso Scale Discovery
  448. Michigan State University
  449. Micron Technology
  450. Microsoft Technology Licensing
  451. Millennium Pharmaceuticals
  452. Miltenyi Biotec
  453. Miraca Life Sciences
  454. Mirati Therapeutics
  455. Mirus Bio
  456. MitoKor
  457. MITRE
  458. Mitsubishi Tanabe Pharma
  459. MMI - Molecular Machines & Industries
  460. Monash University
  461. Monsanto
  462. Morphochem
  463. Murdoch Children's Research Institute
  464. MUSC Foundation for Research Development
  465. Myogen
  466. Nagoya University
  467. Nanjing Agricultural University
  468. Nanjing Anji Biological Technology
  469. Nanjing Legend Biotech
  470. NANJING UNIVERSITY
  471. Nanjing University of Science and Technology
  472. Nankai University
  473. Nano Terra
  474. Nanofactory
  475. Nanosys
  476. Nant Holdings
  477. NantCell
  478. Nanyang Technological University
  479. Nara Institute of Science and Technology (NAIST)
  480. NASA
  481. National Agro-Food Biotechnology Institute
  482. National Brain Research Centre (NBRC)
  483. National Center for Nanoscience and Technology
  484. National Dong Hwa University
  485. National Institute of Advanced Industrial Science and Technology
  486. National Institute of Biological Sciences
  487. National Research Council
  488. National Research Council Canada
  489. National Taiwan University
  490. National University of Singapore
  491. Nationwide Children's Hospital
  492. NeoNeuro
  493. NeoStem Oncology
  494. New Chapter
  495. New Haven, CT
  496. New York Blood Center
  497. Newcastle Innovation
  498. Newcastle University
  499. NewSouth Innovations
  500. NeXstar Pharmaceuticals
  501. Nissan Chemical
  502. Nitt? Denk?
  503. Northern Illinois University
  504. Northwest Normal University
  505. Northwestern University
  506. NOTOX
  507. Nova Chemicals
  508. Nova Southeastern University
  509. Novagenesis Therapeutix
  510. Novartis
  511. Novavax
  512. Novozymes
  513. Nps Pharmaceuticals
  514. NSABP Foundation
  515. NTT Docomo
  516. Nuvelo
  517. Oblique
  518. Obsidian Therapeutics
  519. Ocularis Pharma
  520. Odyssey Thera
  521. Ohio State Innovation Foundation
  522. Ohio State University
  523. Oklahoma Medical Research Foundation
  524. Oklahoma State University–Stillwater
  525. Olivia Newton John Cancer Research Institute
  526. Omega Therapeutics
  527. Oncalis
  528. Oncorus
  529. One Lambda
  530. Opko Health
  531. Oragenics
  532. Oregon Health & Science University
  533. OriMAbs
  534. Orphazyme
  535. Ortho-McNeil Pharmaceutical
  536. Orum Therapeutics
  537. OSI Pharmaceuticals
  538. Ottawa Hospital Research Institute
  539. Oxford University
  540. Oxitec
  541. Oy Jurilab
  542. PANAGENE
  543. Panomics
  544. Paris Descartes University
  545. Paris-Saclay University
  546. Pennsylvania State University
  547. Peptinovo
  548. PerkinElmer
  549. Perlegen Sciences
  550. Pfizer
  551. Pharmacia & Upjohn
  552. Pharmacyclics
  553. Phenex Pharmaceuticals
  554. Phio Pharmaceuticals
  555. Pinteon Therapeutics
  556. Pioneer Hi Bred International
  557. Pivot Bio
  558. Plant Bioscience
  559. Plasma Antennas
  560. PolyGene
  561. Pompeu Fabra University
  562. Precigen
  563. Precision BioSciences
  564. Premium Genetics
  565. Princeton University
  566. Promega
  567. QIMR Berghofer Medical Research Institute
  568. Qingdao Institute of Bioenergy and Bioprocess Technology
  569. Qingdao University
  570. Qingdao University of Science and Technology
  571. Qtg Development
  572. Quantum Precision Instruments
  573. Quantum-Si
  574. Ramot
  575. Rational Affinity Devices
  576. Raytheon BBN
  577. Regen BioPharma
  578. Regeneron Pharmaceuticals
  579. Regenertech
  580. Regenesis Biomedical
  581. Regents of the University of Colorado
  582. REGENXBIO
  583. Research Center for Eco-Environmental Sciences
  584. Research Institute of the McGill University Health Centre
  585. Responsif
  586. Rhodes University
  587. Ribozyme Pharmaceuticals
  588. Rice University
  589. Rigel Pharmaceuticals
  590. Roche
  591. Rochester Institute of Technology
  592. Rockefeller University
  593. Rohm and Haas
  594. Roma Tre University
  595. Roswell Biotechnologies
  596. Rubius Therapeutics
  597. Ruhr University Bochum
  598. Rush University Medical Center
  599. Saint Louis University
  600. Saitama Medical University
  601. Salk Institute for Biological Studies
  602. Samaritan Pharmaceuticals
  603. Samsung
  604. Samumed
  605. Sana Biotechnology
  606. Sandia National Laboratories
  607. Sandoz
  608. Sanford Burnham Prebys
  609. Sanford Burnham Prebys Medical Discovery Institute
  610. Sangamo Therapeutics
  611. Sanofi
  612. Santen
  613. Sapienza University of Rome
  614. Schering
  615. Schering-Plough
  616. Scripps Research Institute
  617. Seattle Children’s Research Institute
  618. Senomyx
  619. Sensei Biotherapeutics
  620. Senti Bio
  621. Seoul Electronics & Telecom
  622. Seoul National University
  623. Serono Genetics Institute
  624. Shandong Agricultural University
  625. Shanghai Cell Therapy Group
  626. Shanghai Institute of Nutrition and Health
  627. Shanghai Jiao Tong University
  628. Shanghai University of Electric Power
  629. Shanxi Agricultural University
  630. Shaoyang University
  631. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS
  632. Shimadzu
  633. Sibelius
  634. Sichuan Huiyu Pharmaceutical
  635. Signase
  636. Sino Biological
  637. SIRION Biotech
  638. SKM PHARMA
  639. Skolkovo Institute of Science and Technology
  640. Snap Bio
  641. SONY
  642. Soochow University
  643. South China Agricultural University
  644. South China Normal University
  645. South Eastern Sydney Local Health District SESLHD
  646. Southeast University
  647. Southern Illinois University
  648. Southern Methodist University
  649. St. Jude Children's Research Hospital
  650. St. Michael’s Hospital
  651. Staidson Beijing Biopharmaceuticals
  652. Stanford Research Institute
  653. Stanford University
  654. State University of New York
  655. STMicroelectronics
  656. STX-Aprilis
  657. Sulzer
  658. Sumitomo Pharma Oncology
  659. Summit
  660. Sungkyunkwan University
  661. SunTracker Technologies
  662. Sure Erasure
  663. Suzhou University
  664. SwanBio Therapeutics
  665. Switch Bio
  666. SWITCH Materials
  667. Symphogen
  668. Syngenta
  669. Synlogic
  670. Synpromics
  671. Syracuse University
  672. SYZ Cell Therapy
  673. Taizhou Vocational & Technical College
  674. Targeted Genetics
  675. TCR2 Therapeutics
  676. Technical University of Munich
  677. Technicon Instruments
  678. Technion – Israel Institute of Technology
  679. Temasek Life Sciences Laboratory
  680. Temple University
  681. Texas A&M University
  682. Texas Biomedical Research Institute
  683. The Institute of Cancer Research
  684. The Leibniz Institute on Aging – Fritz Lipmann Institute
  685. The Wistar Institute
  686. Theodor Kocher Institute
  687. Theras
  688. Thomas Jefferson University
  689. Translational Health Science and Technology Institute
  690. Tianjin Anbisen Biology Technology
  691. Tianjin Hengda Wenbo Science and Technology
  692. Tianma Microelectronics
  693. Tidal Therapeutics
  694. Tissuemed
  695. Tmunity Therapeutics
  696. Tolero Pharmaceuticals
  697. TOLREMO therapeutics
  698. Toulouse III - Paul Sabatier University
  699. Transimmune
  700. Translate Bio
  701. Translational Genomics Research Institute
  702. TransTech Pharma
  703. Trinity College Dublin
  704. Trishula Therapeutics
  705. TRON Translational Oncology
  706. TRT Pharma
  707. Tsinghua University
  708. Tufts University
  709. Tularik
  710. U. S. Genomics
  711. U.S. Department of Health and Human Services
  712. UBE
  713. UCB Biopharma
  714. UCL Business
  715. UCLA
  716. UEA Enterprises
  717. United Arab Emirates University
  718. United States Department of Agriculture
  719. United States Department of Veterans Affairs
  720. Universal Sequencing Technology
  721. Universitat Autònoma de Barcelona
  722. University Clinic Freiburg
  723. University College Cork
  724. University Health Network
  725. University Medical Center Schleswig-Holstein
  726. University of Aberdeen
  727. University of Alberta
  728. University of Angers
  729. University of Arizona
  730. University of Arkansas
  731. University of Basel
  732. University of Bonn
  733. University of Bordeaux
  734. University of Bradford
  735. University of British Columbia
  736. University of Brussels
  737. University of California
  738. University of Cambridge
  739. University of Central Florida
  740. University of Chicago
  741. University of Cologne
  742. University of Colorado
  743. University of Copenhagen
  744. University of Delaware
  745. University of Duisburg-Essen
  746. University of Erlangen–Nuremberg
  747. University of Florida
  748. University of Freiburg
  749. University of Geneva
  750. University of Georgia
  751. University of Heidelberg
  752. University of Helsinki
  753. University of Hong Kong
  754. University of Houston
  755. University of Illinois
  756. University of Iowa Research Foundation
  757. University of Jena
  758. University of Kentucky
  759. University of Konstanz
  760. University of Louisville
  761. University of Magdeburg
  762. University of Manchester
  763. University of Manitoba
  764. University of Maryland
  765. University of Massachusetts
  766. University of Miami
  767. University of Michigan
  768. University of Milano-Bicocca
  769. University of Minnesota
  770. University of Missouri
  771. University of Montpellier
  772. University of Montreal
  773. University of Münster
  774. University of Nantes
  775. University of Naples Federico II
  776. University of New York
  777. University of North Carolina
  778. University of North Carolina at Chapel Hill
  779. University of North Carolina at Charlotte
  780. University of Notre Dame
  781. University of Oslo
  782. University of Ottawa
  783. University of Oxford
  784. University of Pennsylvania
  785. University of Pittsburgh
  786. University of Poitiers
  787. University of Portsmouth
  788. University of Puerto Rico
  789. University of Queensland
  790. University of Regensburg
  791. University of Rennes 1
  792. University of Rochester
  793. University of Rome Tor Vergata
  794. University of Saskatchewan
  795. University of Sheffield
  796. University of South Carolina
  797. University of South Dakota
  798. University of South Florida
  799. University of Southern California
  800. University of Southwest
  801. University of Stanford
  802. University of Stuttgart
  803. University of Sussex
  804. University of Texas
  805. University of the Witwatersrand
  806. University of Tokyo
  807. University of Toyama
  808. University of Tübingen
  809. University of Utah
  810. University of Vermont
  811. University of Verona
  812. University of Virginia
  813. University of Washington
  814. University of Wyoming
  815. University of York
  816. University of Zurich
  817. University Research Corp
  818. University of Toledo
  819. UNM Rainforest Innovations
  820. Upjohn
  821. Utah State University
  822. Valentis
  823. Valio
  824. Vanderbilt University
  825. VastCon
  826. Vegenics
  827. Ventana Medical Systems
  828. Verastem
  829. Verily Life Sciences
  830. Vernalis
  831. VEROVACCiNES
  832. Vestion
  833. Vgx Pharmaceuticals
  834. Vidya Herbs
  835. Virginia Tech
  836. Virginia Tech Intellectual Properties
  837. ViroMed
  838. Vlaams Institute of Biotechnology
  839. Voronoi
  840. Voyager Therapeutics
  841. Wake Forest University
  842. Walter and Eliza Hall Institute of Medical Research
  843. Warner–Lambert
  844. Wayne State University
  845. Whitehead Institute
  846. WindMIL Therapeutics
  847. Wisconsin Alumni Research Foundation
  848. WisTa Laboratories
  849. Wistar Institute
  850. WiSys
  851. Wuhan HealthCare Biotechnology
  852. WuXi Biologics
  853. Wyeth
  854. Xenogen
  855. Xiamen University
  856. Xi'an University of Science and Technology
  857. Xilinx
  858. Xuanwu Hospital Capital Medical University
  859. Yale University
  860. YEDA
  861. Yeditepe University
  862. Yissum
  863. Zeneca
  864. Zhejiang Academy of Agricultural Sciences
  865. Zhejiang University
  866. ZymoGenetics
  867. ZyngeniaSalix Pharmaceuticals

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