mRNA Therapeutics and Vaccines Market

mRNA Therapeutics and Vaccines: Key Opinion Leaders

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mRNA Therapeutics and Vaccines Market Overview

Over the last two decades, medical researchers have been able to achieve proof-of-concept and demonstrate the viability of benefits of mRNA-based interventions. In fact, currently, there are more than 65 mRNA-based therapeutics and over 85 mRNA vaccines under development. In vitro transcribed mRNA is now being evaluated as a treatment option for several oncological and genetic disorders. Moreover, experts believe that the applications of this upcoming product class are potentially limitless. Synthetic mRNA can also be engineered to facilitate the in vitro development of several types of cell and gene therapies. For instance, it can be used to activate key molecular pathways in somatic cells in order to induce pluripotency, an important prerequisite for stem cell therapy. There are studies that describe the use of in vitro transcribed mRNA encoding novel designer nucleases to manipulate genetic material, which is a common practice in the development of advanced therapy medicinal products. Further, the COVID-19 pandemic has enabled medical researchers to realize the vast potential of mRNA-based vaccines. Contrary to traditional vaccinology, the aforementioned type of preventive interventions do not require the use of live (attenuated) pathogens, hence, are significantly less risky. Moreover, mRNA is expressed in the cytoplasm and does not enter cellular nuclei, implying that it is incapable of adversely interacting with the genome of patients. In this context, it is worth mentioning that the mRNA vaccines developed by Pfizer / BioNtech (COMIRNATY® / BNT-162) and Moderna (SpikeVax / mRNA-1273) against the novel coronavirus strain, were, for the first time in the history of vaccine development, developed and approved for use, in under a year. 

The context of mRNA therapeutics and vaccines market report, published by Roots Analysis This image highlights the experts opinion on mRNA therapeutics and vaccines This infographics presents mRNA based interventions

Being a biomolecule, mRNA is well tolerated in vivo; however, despite its numerous benefits, there are several challenges that presently limit its use. Although recent advances in controlling translational efficacy and immunogenicity have led to the development of multiple viable pharmacological leads (a few of which are already approved for use), there are still several challenges that need to be addressed. One of the major concerns is related to the inherent instability, which significantly compromises in vivo persistence, of the molecule. In addition, the targeted in vivo delivery of this relatively fragile type of intervention is also complicated. Over the years, attempts to manipulate the chemical structure of mRNA have enabled therapy developers to engineer relative more stable versions of the molecule. Similarly, lipoplexes and lipid-based nanoparticles have been successfully used to administer mRNA-based vaccines. Given that many companies (most of which have fairly limited expertise) are now in pursuit of further improving this technology, and the fact that standards related to the safety and regulation of such interventions are subject to increasing stringency, the need for expert guidance on new molecular entity design and product development is paramount. Contemporary scientific expertise in mRNA, and its numerous applications, is backed by more than 20 years of dedicated research in this field. This primary objective of this report is to identify leading scientists and industry leaders in this domain and assess the impact of their contributions to the field, till date.

List of key opinion leaders in mRNA therapeutics and vaccines from the research report of Roots Analysis This image presents the distribution of key opinion leaders in mRNA therapeutics and vaccines market This image evaluate the relative expertise and impact of contributions made to the field of mRNA therapeutics and vaccines

Scope of the Report

The “Key Opinion Leaders in mRNA Therapeutics and Vaccines” report features the identities of some of the key opinion leaders in this domain, offering a quantitative approach to assess the relative expertise of thought leaders in this subject, along with the means for aspiring therapy developers to contact such eminent personalities. The information in this report has been presented across two deliverables, namely an Excel sheet, featuring an interactive dashboard, and a PowerPoint deck, summarizing the ongoing activity in this domain, and key insights drawn from the available data.

This image presents the analysis of KOL Expertise based on the relative experience in mRNA therapeutics and vaccines domain Competitive analysis of key opinion leaders in mRNA therapeutics and vaccines domain, from Roots Analysis report This image presents the example of key leader in the domain of mRNA therapeutics and vaccines

The report features the following details:

  • Identities of Contemporary KOLs

An in-depth analysis of leading technical experts in the field of mRNA therapeutics and vaccines, featuring a quantitative assessment of all the available details across 30+ parameters related to individual KOLs, including the contact information (email ID, and links to their respective LinkedIn and ResearchGate profile, as well as other details) of those individuals who have publicly disclosed such details

  • Assessment of Technical Expertise and Relative Impact on the Field of mRNA-based Interventions

An analysis of 25+ different (quantifiable) parameters, indicative of the expertise and impact created by different types of KOLs in this domain. The parameters considered in this analysis include inputs from publicly available information that describe experience, technical acumen, scientific activity, impact of contributions, strength of professional network, social media activity, and geographical location of individual KOLs

  • KOL Competitiveness Analysis

A competitive benchmarking and valuation analysis, taking into account all available data on 25+ parameters that highlight the relative strength (technical expertise) and impact created on the industry, by individual KOLs

  • KOL Profiles and Recent Activity Snapshots

Detailed profiles of top-ranking KOLs (according to our proprietary competitiveness analysis), featuring all available details, including (but not limited to) years of experience (both general and specific to mRNA-based research), educational qualifications, previous / current affiliations, previous / current designations, strength of professional networks (LinkedIn and ResearchGate), scientific activity (such as number of publications, and trials conducted), and contact information (as disclosed by individual KOLs in the public domain). In addition, this section includes brief snapshots of some of the recent contributions (such as publications, clinical trials conducted, keynote speeches delivered and posts on social media) of the KOLs captured in the report database, who have been profiled

Deliverable Outlines

Excel Deliverable

  1. The first section of the spreadsheet features details on the scope of the report and the inclusion and exclusion criteria taken into consideration during the data collection phase.
  2. The second section of the deliverable is a summary MS Excel dashboard, offering a detailed graphical perspective of the contemporary KOL landscape, featuring innovation and knowledge leaders, clinical research investigators, technical domain experts and industry leaders. 
  3. The third section of the spreadsheet is an elaborate table, which provides information on the leading technical experts in the field of mRNA therapeutics and vaccines. It features all the available details (across 30+ parameters) related to individual KOLs, for whom the relevant details are available in the public domain. 

PowerPoint Deliverable

  1. The first part of this deliverable features an executive summary of the key insights generated from an in-depth analysis of various KOLs who are engaged in conducting research on mRNA and / or the development of mRNA-based therapeutics and vaccines.
  2. The next section is a broad perspective on the various types of KOLs that have been captured in this report and details related to their experience (past / current) and the various contributions that they have made in the field of mRNA therapeutics and vaccines. 
  3. The third section of the deliverable features an analysis of 17 different (quantifiable) parameters based on which we have developed an informed opinion on the relative strength of an individual KOL in this domain. The aforementioned parameters include inputs from publicly available information that describe the experience, technical acumen, strength of professional network, social media activity and geographical location, of individual KOLs.
  4. In this section of the deliverable, we have quantified and analyzed 10 different parameters to develop an informed opinion on the relative impact that an individual KOL has had in this domain. The aforementioned parameters include inputs from publicly available information that describe the scientific activity and impact of contributions of individual KOLs.
  5. Based on our understanding of the relative strength and impact on industry, an elaborate 2×2 matrix was plotted to assess the competitiveness of individual KOLs. From the matrix, all of the individuals with high strength and impact scores were separately inspected against the contributions that they have made so far, in this domain. Further, a cumulative score (which takes into account both the aforementioned parameters) was assigned to each KOL and compared to a similar numerical value, which reflects the relative expertise of a knowledge leader, from a reliable third-party source.    
  6. Finally, the report features profiles of prominent KOLs who emerged from among the top-ranking individuals (based on relative strength and impact on industry) in our proprietary competitiveness analysis. Each profile features all available details on the various KOLs who have been captured in the report. Further, we have provided snapshots of some of the recent contributions (such as publications, clinical trials conducted, keynote speeches delivered and posts on social media) of the same individuals.

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