NGS-Based RNA-Sequencing Market

NGS-based RNA-Sequencing Market Overview

The NGS-based RNA-sequencing market is estimated to grow from USD 3.59 billion in 2024 to reach USD 4.41 billion in 2025 and USD 22.44 billion by 2035, representing a CAGR of 17.7% during the forecast period.

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NGS-based RNA-sequencing refers to the analysis of RNA molecules by using next-generation sequencing technology in a biological sample. This procedure allows researchers to qualitatively and quantitatively investigate different RNA types, such as microRNAs, mRNA and more.

NGS-based RNA-sequencing technology offers several advantages, such as high throughput, precision and ability to detect splice sites which makes it a valuable tool to study gene expression. The market for NGS-based RNA-sequencing is fueled by the rising focus on whole genome sequencing studies and transcriptome profiles to design personalized medicine.

Furthermore, the expanding applications of NGS-based RNA-sequencing in drug development, biomarkers identification and disease diagnosis are increasing their demand. Currently, there are several next-generation sequencing service providers that are aiming to develop high throughput sequencing platforms. Market players, such as BGI Genomics, Illumina and Roche are focusing on RNA sequencing technology innovations.

For instance, in February 2025, Roche unveiled a new category of next-generation sequencing technology, namely (sequencing by expansion (SBX) technology). This technology combine an innovative sensor module to offer ultra-rapid high-throughput sequencing that is both scalable and flexible for decoding complex diseases, such as neurodegenerative conditions, immune disorders and cancer.

Driven by the focus of industrial players and expanding application of next generation sequencing, we believe that the market for NGS-based RNA-sequencing is anticipated to witness noteworthy growth during the forecast period.

NGS-Based RNA-Sequencing Market: Report Attributes

Key Report Attributes	Details
Historical Trend	Since 2020
Forecast Period	Till 2035
Market Size 2025	USD 4.41 Billion
Market Size 2035	USD 22.44 Billion
CAGR (Till 2035)	17.7%

One of the key objectives of the NGS-based RNA-sequencing market report was to estimate the current size, opportunity, and the market growth potential, over the forecast period, till 2035. We have provided informed estimates on the likely evolution of the market for the forecast period.

The global market analysis report also features the likely distribution of the current and forecasted opportunity within the market across various segments, such as type of offering, type of workflow, type of technology, application area, end users, geographical regions and leading players.

In order to account for future uncertainties associated with some of the key parameters and to add robustness to our model, we have provided three NGS-based RNA-sequencing market forecast scenarios, namely conservative, base, and optimistic scenarios, representing different tracks of industry’s evolution.

Recent Developments in NGS-Based RNA-Sequencing Market

Several recent developments have taken place in the field of NGS-based RNA-sequencing, and we outline some of these below.

• In February 2025, New England Biolabs (NEB^®) presented as a host of technologies aimed at streamlining sample preparation technologies towards the production of high-quality sequencing data at Advances in Genome Biology and Technology General Meeting. During this meeting, the company has shared about recently releases NEBNext^® Enzymatic Methyl-seq v2 kit that expands dynamic input range for the technology down to 100 picograms of DNA and RNA mass.
• In February 2025, Ultima Genomics commercially launched UG 100 Solaris at the Advances in Genome Biology and Technology Conference. UG 100 Solaris advanced software and new chemistry to increase the output and reduce the cost of UG 100 sequencing platform.
• In February 2025, MGI Tech revealed DNBSEQ-T1+ and DNBSEQ-E25 Flash, its latest high performance RNA-sequencing solutions at Advanced in Genome Biology and Technology General Meeting. These new sequencing solutions are designed to deliver high speed, throughput and efficiency to empower researchers with high-quality genomic data.

NGS-Based RNA-Sequencing Market Segmentation Insights

The market report provides comprehensive information on stakeholders in the NGS-based RNA-sequencing industry who are currently active across various segments of the industry as mentioned in the table below.

NGS-Based RNA-Sequencing Market: Market Segmentation

Market Segmentations	Details
Type of Offering	Consumables (Extraction & Purification Kits, Library Preparation Kits, Sequencing Reagents & Flow Cells, and Others) Instruments Service (RNA-sequencing, and Bioinformatics & Data Analysis)
Type of Workflow	Pre-sequencing Sequencing Data Analysis
Type of Technology	Nanopore Sequencing Sequencing by Synthesis Ion Semiconductor Sequencing Single-Molecule Real-Time Sequencing
Application Area	Drug Discovery & Development (Oncology, Infectious Diseases, and Others) Clinical Diagnostics Other Applications
End User	Academic & Research Institutes Pharmaceutical & Biotechnology Companies Hospitals & Clinics Other End Users
Geographical Regions	North America Europe Asia-Pacific Middle East and North Africa Latin America
Market in North America	US Canada Mexico
Market in Europe	France Germany Italy Spain UK Rest of Europe
Market in Asia-Pacific	China India Japan South Korea Rest of the Asia-Pacific
Market in Middle East and North Africa	Egypt Saudi Arabia United Arab Emirates
Market in Latin America	Argentina Brazil

NGS-Based RNA-Sequencing Market Share Insights

Market Share by Type of Offering

• Based on the type of offering, the global market is segmented into consumables (extraction & purification kits, library preparation kits, sequencing reagents & flow cells, and others), instruments, and service (RNA-sequencing, and bioinformatics & data analysis).
• According to our NGS-based RNA-sequencing market report, presently, the consumables segment is holding the maximum share (53.02%) of the market. Notably, this trend of dominance is likely to remain unchanged during the forecast period. This can be attributed to the high demand of consumables for genome sequence and analysis across research institutes.
• Notably, the services segment is likely to grow at a higher CAGR during the forecast period. This is potentially due to the rising preferences for third-party service providers for genomics.

Market Share by Type of Workflow

• The global market is bifurcated across different type of workflow, such as pre-sequencing, sequencing, and data analysis. Currently, sequencing segment dominates the industry by holding highest NGS-based RNA-sequencing market share. The highest share is due to the growing demand for advanced next-generation sequencing solutions for sequencing a wide range of RNA molecules.
• Interestingly, the data analysis segment is likely to register the fastest CAGR during the forecast period. This is primarily fueled by the high demand for advanced data interpretation solutions to gain better insight into sequenced data. Furthermore, industrial players are increasing technological innovations, such as machine learning, artificial intelligence and cloud-based platforms to enhance accuracy and high data interpretation efficiency.

Market Share by Type of Technology

• The market for NGS-based RNA-sequencing is categorized across different types of technology, such as nanopore sequencing, sequencing by synthesis, ion semiconductor sequencing and single-molecule real-time sequencing.
• Based on the current trend, sequencing by synthesis segment is holding highest share of NGS-based RNA-sequencing market analysis. Sequencing by synthesis technology offers high speed, accuracy for RNA-sequencing and a wide range of applications, such as RNA editing analysis, alternate splicing analysis, and gene expression profiling.
• In addition, the increasing advances in data analysis technologies for minimizing sequencing errors and enhancement of sequencing accuracy is likely to fuel its demand across pharmaceutical and research organizations. Driven by its high demand, this segment will continue to expand at a higher CAGR during the forecast period.

Market Share by Application Area

• Based on the application area, the global market is distributed into drug discovery & development (oncology, infectious diseases, and others), clinical diagnostics and other applications. It is worth mentioning that the drug discovery & development segment holds the largest NGS-based RNA-sequencing market share (61.77%).
• RNA-sequencing technologies are widely adopted by pharmaceutical companies to identify drug targets, biomarkers, and understand the underlying mechanism of diseases. Moreover, RNA-sequencing technologies offer gene expression profiling with higher precision which further helps to develop targeted therapies and reduce time for clinical trials.
• It is worth mentioning that clinical diagnostic segment is likely to experience higher CAGR driven by the growing demand for next-generation sequencing technologies for disease diagnosis and designing treatment plans. NGS technologies also help to identify gene mutations, which is a major reason for genetic diseases and cancer. The rising emphasis on early disease detection is likely to fuel the demand for next generation sequencing technologies for clinical diagnostic.

Market Share by End User

On the basis of end user, the global market is segmented into academic & research institutes, pharmaceutical & biotechnology companies, hospitals & clinics, and other end users. According to the NGS-based RNA-sequencing market forecast, the pharmaceutical & biotechnology companies segment holds the highest share (36.82%) of the market. Pharmaceutical and biotechnology companies are extensively adopting next generation RNA-sequencing technology for biomarkers identification, drug discovery and targeted therapies development.

Meanwhile, it is expected that hospitals & clinics’ segment will grow at a substantial CAGR during the forecast period. This lucrative growth is due to the increasing usage of NGS-based RNA-sequencing technologies for disease diagnosis.

Market Share by Geographical Regions

• The global market is distributed across different regions, such as North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America. Among these regions, currently North America is dominating by holding 47.39% of the global NGS-based RNA-sequencing market share. This can be attributed to the rising adoption of next-generation RNA-sequencing technologies across healthcare industry and pharmaceutical industry for clinical diagnostics, drug development and genomic research.
• In Asia-Pacific, the market is expected to show lucrative growth, registering a higher CAGR in the upcoming years. Several factors, such as rising healthcare expenditure, heightened demand for advanced clinical diagnostics solutions and expanding government initiatives to support genomic research are the key drivers for unprecedented growth.

NGS-Based RNA-Sequencing Market: Report Deliverables

Report Deliverables	Details
Excel Data Packs (Complimentary)	Available
Key NGS-Based RNA-Sequencing Companies Profiled	10x Genomics Agilent Technologies BGI Genomics Bio- Rad Laboratories Eurofins Genomics Genewiz GATC Biotech Macrogen Novogene Illumina Lexogen Oxford Nanopore Technologies Pacific Biosciences Perkin Elmer Qiagen Roche Singular Genomics Thermo Fisher Scientific Takara Bio Zymo Research (A complete list of companies captured is available in the report)
PowerPoint Presentation (Complimentary)	Available
Customization Scope	15% Free Customization

NGS-Based RNA-Sequencing Market Major Takeaways

The “NGS-Based RNA-Sequencing Market: Industry Trends and Global Forecasts, till 2035” market report features an extensive study of the current market landscape, market size, market share, market growth, market trends, market value, market forecast, market outlook, statistics, and future opportunities for NGS-based RNA-sequencing industry players. The market research report lays emphasis on the NGS-based RNA-sequencing consumables, instruments and services. Key takeaways of the market report are briefly discussed below.

NGS-Based RNA-Sequencing Market Competitive Landscape

Currently, the market landscape is highly consolidated with the presence of small, mid-sized and large companies. Industrial players, such as Illumina, QIAGEN and Thermo Fisher Scientific are aiming to launch new products, making investments to stay robust in this competitive market.

As more industrial players continue to show keen interest in the development of NGS-based RNA-sequencing technologies, we believe this industry will remain competitive during the forecast period.

Market Size Analysis: What are the Key Opportunities in the Market For NGS-Based RNA-Sequencing?

In 2025, the NGS-based RNA-sequencing market is estimated at USD 4.41 billion and is projected to reach USD 22.44 billion by 2035. The key opportunities come across the products and services segment. It is worth mentioning that with heightened demand for consumables and next generation sequencing platforms / technologies and services, various market players are investing heavily in this segment.

What are the Key NGS-Based RNA-Sequencing Market Drivers?

Increasing Incidence of Genetic and Oncological Disorders

One of the key factors that are driving the market for NGS-based RNA-sequencing includes rising incidence of genetic and oncological disorders. According to the statistics published in the National Cancer Institute, in 2025, around 2,041,910 cases of cancer will be diagnosed in the US. In order to mitigate the growing concern of cancer, healthcare experts are relying on advanced next generation sequencing technologies and platforms to identify the underlying mechanism of diseases.

Expanding Research on Genomics

Notably, the growing expansion of genomic research has further necessitated the demand for NGS-based RNA-sequencing technologies. Interestingly, NGS-based RNA-sequencing technologies help to evaluate the RNA molecules that are directly related to gene mutations. Thus, growing usage of next generation sequencing is expected to be a key driver for the market.

What Factors are Restricting NGS-Based RNA-Sequencing Market Growth?

High Cost of Next Generation Sequencing Technologies

One of the potential factors that are limiting market growth includes the high cost of the next generation sequencing technologies. For instance, the Ion ReproSeq™ PGT-A GX5 kit of Thermo Fisher Scientific which can sequence around 192 samples can cost around USD 35,690. The high cost may limit its adoption across low to middle income countries.

Lack of Data Standardization and Data Complexity

Next generation sequencing technologies generate vast amounts of complex data which require specialized sequencing tools for effect processing, interpretation and management. Lack of data standardization tools and protocols can hinder market growth, affecting adoption across the globe.

What are the Major NGS-Based RNA-Sequencing Market Trends?

Growing Focus on Technological Advancements

Driven by its high demand, several industrial players are focusing on advancing NGS-based RNA-sequencing platforms, such as development of long-read sequencing platforms and AI integration. Notably, automation of next generation sequencing technologies will remain one of the key trends of the market.

Rising Focus on NGS-based RNA-Sequencing Platforms for Precision Medicine Applications

The growing focus on oncology precision medicine to meet individual patients needs is further increasing the adoption of next generation sequencing technologies. It is worth noting that NGS-based RNA-sequencing platforms and kits help to understand the molecular basis of diseases and enables researchers to identify the drug targets, which is expected to be its key growth factor. Furthermore, the growing expansion across various research applications, such as genomics, transcriptomics and biomarker discovery, is further offering enormous opportunities to industrial players for innovations.

NGS-Based RNA-Sequencing Report Coverage

The market report presents an in-depth analysis, highlighting the capabilities of various stakeholders in the NGS-based RNA-sequencing industry, across different geographies. Amongst other elements, the market report includes:

• An Infographic Executive Summary
• Market Landscape of NGS-Based RNA-Sequencing Product and Service Providers
• Company Competitiveness Analysis
• Company Profiles
• SWOT Analysis
• Market Impact Analysis
• Market Forecast Analysis

From the Author’s Desk

Author’s View on NGS-Based RNA-Sequencing Market

NGS-based RNA-sequencing industry is witnessing a significant stride driven by the expanding usage across a wide range of healthcare and pharmaceutical applications. Product innovation remains a critical focus area for market players, with recent developments including improved library preparation protocols that reduce input RNA requirements, enhanced multiplexing capabilities for higher throughput, and simplified workflows for clinical applications. Additionally, numerous cross-industry collaborations between sequencing technology providers and pharmaceutical companies have emerged to develop companion diagnostics and advance precision medicine initiatives.

Glossary

• NGS-Based RNA-sequencing: It referred to as RNA-sequencing or RNA-seq, has revolutionized the field of transcriptomics by allowing researchers to analyze the presence and quantity of RNA molecules in biological samples with unprecedented depth and accuracy.
• Next Generation Sequencing (NGS): It is a technology or platform that allows rapid sequencing of DNA and RNA. Unlike conventionally available sequencing methods, such as Sanger sequencing, NGS can sequence millions of DNA / RNA fragments simultaneously, allowing researchers to analyze large amounts of genome data.
• RNA-Sequencing: It is a technique of determining the sequence / order of nucleotide bases in an RNA molecule for studying gene expression, revealing the comprehensive set of RNA inside the cell, known as the transcriptome.