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Report Description
Monoclonal antibodies have been in use for more than two decades. The first product candidate was launched in 1986; since then, they have been used for the treatment of a myriad of diseases, including cancer, inflammatory diseases and infectious diseases. However, despite their clinical and commercial successes, these therapies are known to have certain drawbacks that have had an impact on their overall efficacy, thereby, limiting their therapeutic potential. These drawbacks are related to their inherent structural complexities, high manufacturing costs, difficulties in formulation and insufficient understanding of their precise in vivo mechanisms of action.
The above-mentioned limitations have prompted researchers to identify alternative protein scaffold based therapeutic strategies. Amongst other novel formats, non-antibody protein scaffolds have emerged as viable alternatives, having the capability to address the existing challenges associated with classical antibody based therapies. Although the concept of non-antibody protein scaffolds was conceived more than a decade ago, this field has gained popularity in recent years. Presently, there is one approved product (Kalbitor®), and several non-antibody protein scaffold based product candidates that are being developed across various clinical and preclinical stages.Monoclonal antibodies have been in use for more than two decades. The first product candidate was launched in 1986; since then, they have been used for the treatment of a myriad of diseases, including cancer, inflammatory diseases and infectious diseases. However, despite their clinical and commercial successes, these therapies are known to have certain drawbacks that have had an impact on their overall efficacy, thereby, limiting their therapeutic potential. These drawbacks are related to their inherent structural complexities, high manufacturing costs, difficulties in formulation and insufficient understanding of their precise in vivo mechanisms of action.
Scope of the Report
The ‘Non-Antibody Protein Scaffolds: Drugs and Diagnostics Market, 2017-2030’ report provides a comprehensive study of the current market landscape of non-antibody protein scaffolds, and related drugs and diagnostics, featuring an elaborate discussion on the likely future potential of this upcoming market. Over the past few years, this burgeoning field of research has captured the interest of several players in the pharmaceutical industry. Amongst other elements, the report features:
One of the key objectives of this report was to evaluate the current opportunity and the future potential of the non-antibody protein scaffolds market. Based on various parameters, such as target patient population, likely adoption rates and expected pricing, we have provided an informed estimate of the likely evolution of the market in the short to mid-term and long term, for the period 2017-2030. In addition, we have provided the likely distribution of the market based on end-use (therapeutic agents and diagnostic agents), key therapeutic areas (genetic disorders, eye disorders, autoimmune disorders, oncology and others), and non-antibody protein scaffold technologies. To account for the uncertainties associated with the development of non-antibody protein scaffold based drugs / diagnostics and to add robustness to our model, we have provided three forecast scenarios, portraying the conservative, base and optimistic tracks of the market’s evolution.
The opinions and insights presented in the report were also influenced by discussions with senior stakeholders in the industry. These include Alastair Smith (CEO, Avacta), Kyu-Tae-Kim (Director, AbClon), Ratmir Derda (Assistant Professor, University of Alberta) and Aditya Pandey (Postdoctoral Fellow, University of Toronto). All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.
Contents
Chapter 2 provides an executive summary of the insights captured during our research. It offers a high-level view on the likely evolution of the non-antibody protein scaffolds based drugs / diagnostics market in the short to mid-term and long term.
Chapter 3 provides a general overview of the evolution of protein based therapeutics over the last several years, featuring a brief discussion on the limitations of antibody based therapeutics and emphasizing on the need for alternative protein scaffolds. It includes a detailed description of non-antibody protein scaffolds, elaborating on their historical evolution, classification and key benefits. It also highlights major types of proteins that are usually tagged with non-antibody protein scaffolds for therapeutic, diagnostic and research purposes. In addition, the chapter features a detailed discussion on different applications of non-antibody protein scaffolds.
Chapter 4 provides a detailed overview of the non-antibody protein scaffold technologies identified during this study. It features a detailed discussion on the impact of various structural and pharmacokinetic features (such as size, origin of the parent protein, structure, mode of randomization and number of disulphide bonds, production system, method of selection , in vitro half-life and melting temperatures) on drug development. The chapter also presents a comparative 2 X 2 matrix analysis of non-antibody protein scaffolds that are presently under preclinical / clinical evaluation. Additionally, it features a spider-web analysis, which highlights the relative popularity of those non-antibody protein scaffolds that have products in clinical stages of development (phase I and above). The parameters considered for this analysis include pipeline strength (based on the number of drugs in both preclinical / clinical stages of development), end-use, number of publications, indication coverage and technical strength of the scaffolds.
Chapter 5 provides a comprehensive overview of the current landscape of the non-antibody protein scaffold based drugs / diagnostics market. It includes information on over 80 non-antibody protein scaffolds based products that are currently in various stages of development (both clinical and preclinical / discovery). It features a comprehensive analysis of the pipeline products on the basis of their phase of development, target therapeutic area(s), end-use, type of scaffold format, route of administration and non-antibody protein scaffold technology. We have also highlighted the key players that are active in this domain.
Chapter 6 presents elaborate profiles of drugs / diagnostic agents that are either marketed or are in advanced stages of clinical development (phase I/II and above). Each profile provides information on the history of development, mechanism of action, non-antibody protein scaffold technology, manufacturing details, current status of development, information on clinical studies, key clinical trial results, target patient population and historical sales of the products ( if marketed ). It also includes a brief overview of the developer, its financial information, funding details and an informed future outlook.
Chapter 7 presents a comprehensive market forecast analysis, highlighting the future potential of the market till the year 2030. It includes future sales projections of non-antibody protein scaffolds based drugs / diagnostics that are either marketed or are in advanced stages of clinical development (phase II and above). The sales potential and growth opportunity were estimated based on the target patient population, likely adoption rates, existing / future competition from other drug classes and the likely price of products. The chapter also presents a detailed market segmentation on the basis of key therapeutic areas (genetic disorders, eye disorders, autoimmune disorders, oncology and others), end-use (therapeutic agents and diagnostic agents), and non-antibody protein scaffolds technologies.
Chapter 8 features an elaborate discussion and analysis of the various collaborations and partnerships that have been inked amongst players in this market. We have also discussed the different partnership models (including R&D agreements, product / technology licensing agreements, product development / commercialization agreements, merger / acquisitions and clinical trial collaborations) and the most common forms of deals / agreements that have been established between 2012 and 2017.
Chapter 9 presents the key insights derived from the study. It distinctly highlights the most popular targets that are being investigated for both therapeutic, as well as diagnostic purposes along with their respective types of formats and highest phase of development. The chapter also features a grid analysis, representing the distribution of non-antibody protein scaffold based products (on the basis of their end-use) across target therapeutic areas and stages of development. In addition, it features a logo landscape of industry and non-industry players engaged in the development of non-antibody protein scaffold based products, distributed based on the developmental status of pipeline candidates and size of the companies (small, mid-sized and large companies). We have also mapped the geographical presence of various industry players involved in the development of product candidates in this field. In addition, it includes a comparative analysis, presented in the form of a bubble analysis, to highlight the leading players engaged in the generation of drugs / diagnosticsbased on these novel non-antibody protein scaffolds. The parameters considered for this analysis include the research activity based on the company’s development pipeline (in terms of the number of drugs across different phases of development), number of partnerships established related to each company (between 2012 and 2017) and the size of the developer company.
Chapter 10 summarizes the overall report. In this chapter, we have provided a list of key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.
Chapter 11 is a collection of interview transcripts of the discussions that were held with key stakeholders in this field.In this chapter, we have presented the details of our conversations withAlastair Smith (CEO, Avacta), Kyu-Tae-Kim (Director, AbClon), Ratmir Derda (Assistant Professor, University of Alberta) and Aditya Pandey (Postdoctoral Fellow, University of Toronto).
Chapter 12 is an appendix, which provides tabulated data and numbers for all the figures provided in the report.
Chapter 13 is an appendix, which provides the list of companies and organizations mentioned in the report.
1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Chapter Overview
3.2. Antibodies as Therapeutic Agents
3.2.1. Structure of an Antibody
3.2.2. Antibody Therapeutics: A Lucrative Market
3.3. Need for Alternative Protein Scaffolds
3.4. Introduction and Classification of Alternative Protein Scaffolds
3.4.1. Antibody-Derived Protein Scaffolds / Engineered Antibody Fragments
3.4.2. Non-Antibody Protein Scaffolds
3.5. A Detailed Overview of Non-Antibody Protein Scaffolds
3.5.1. Evolution of Non-Antibody Protein Scaffolds
3.5.2. Classification of Non-Antibody Protein Scaffolds
3.5.3. Advantages and Limitations of Non-Antibody Protein Scaffolds
3.6. Key Targets for Non-Antibody Protein Scaffolds
3.7. Applications of Non-Antibody Protein Scaffolds
3.7.1. Therapeutic Applications
3.7.2. Diagnostic Applications
3.7.3. Basic and Applied Research
3.8. Future Outlook of Non-Antibody Protein Scaffolds
4. NON-ANTIBODY PROTEIN SCAFFOLDS: A DETAILED COMPARISON
4.1. Chapter Overview
4.2. Key Requisites for Selection of a Suitable Scaffold
4.3. Key Parameters for Drug Development using Non-Antibody Protein Scaffolds
4.3.1. Small Size and Tissue Penetration
4.3.2. Origin of Parent Protein and Immunogenicity
4.3.3. Serum Half-Life and Renal Clearance
4.3.4. Melting Temperature and Thermodynamic Stability
4.3.5. Oral Administration
4.3.6. Multivalency and Multispecificity
4.3.7. Production System and Cost of Manufacturing
4.4. List of Non-Antibody Protein Scaffolds
4.4.1. Non-Antibody Protein Scaffolds: Distribution by Scaffold Class
4.4.2. Non-Antibody Protein Scaffolds: Distribution by Origin of Parent Protein
4.5. Non-Antibody Protein Scaffolds: 2 x 2 Matrix Analysis
4.6. Non-Antibody Protein Scaffolds: 5D Spider-Web Analysis
5. MARKET OVERVIEW
5.1. Chapter Overview
5.2. Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Development Pipeline
5.2.1. Distribution by Phase of Development
5.2.2 Distribution by End-Use
5.2.3. Distribution by Therapeutic Area
5.2.4. Distribution by Type of Format
5.2.5. Distribution by Route of Administration
5.2.6. Distribution by Non-Antibody Protein Scaffold Technology
5.2.7. Distribution by Leading Players
5.3. Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Terminated / Discontinued Candidates
6. DRUG / DIAGNOSTIC AGENTS: PROFILES
6.1. Chapter Overview
6.2. Kalbitor® / Ecallantide / DX-88 (Shire)
6.2.1. Overview
6.2.2. History of Development
6.2.3. Mechanism of Action
6.2.4. Dosage Form, Regimen and Price
6.2.5. Technology Overview
6.2.6. Manufacturing Information
6.2.7. Current Status of Development
6.2.8. Clinical Studies
6.2.9. Key Clinical Trial Results
6.2.10. Target Patient Population
6.2.11. Historical Sales
6.2.12. Developer Overview: Shire
6.2.12.1. Financial Information
6.2.12.2. Future Outlook
6.3. Abicipar Pegol / AGN-150998 / MP0112 (Allergan)
6.3.1. Overview
6.3.2. History of Development
6.3.3. Mechanism of Action
6.3.4. Technology Overview
6.3.5. Current Status of Development
6.3.6. Clinical Studies
6.3.7. Key Clinical Trial Results
6.3.8. Target Patient Population
6.3.9. Developer Overview: Allergan
6.3.9.1. Financial Information
6.3.9.2. Future Outlook
6.4. RG6206 / RO7239361 / BMS-986089 (Roche)
6.4.1. Overview
6.4.2. Mechanism of Action
6.4.3. Technology Overview
6.4.4. Current Status of Development
6.4.5. Clinical Studies
6.4.6. Key Clinical Trial Results
6.4.7. Target Patient Population
6.4.8. Developer Overview: Roche
6.4.8.1. Financial Information
6.4.8.2. Future Outlook
6.5. ABY-002 / ABY-025 (Affibody)
6.5.1. Overview
6.5.2. Mechanism of Action
6.5.3. Technology Overview
6.5.4. Current Status of Development
6.5.5. Clinical Studies
6.5.6. Key Clinical Trial Results
6.5.7. Target Patient Population
6.5.8. Developer Overview: Affibody
6.5.8.1. Financial Information
6.5.8.2. Future Outlook
6.6. ABY-035 / AFB-035 (Affibody)
6.6.1. Overview
6.6.2. Mechanism of Action
6.6.3. Technology Overview
6.6.4. Current Status of Development
6.6.5. Clinical Studies
6.6.6. Key Clinical Trial Results
6.6.7. Target Patient Population
6.6.8. Developer Overview: Affibody
6.6.8.1. Financial Information
6.6.8.2. Future Outlook
6.7. MP0250 (Molecular Partners)
6.7.1. Overview
6.7.2. Mechanism of Action
6.7.3. Technology Overview
6.7.4. Current Status of Development
6.7.5. Clinical Studies
6.7.6. Key Clinical Trial Results
6.7.7. Target Patient Population
6.7.8. Developer Overview: Molecular Partners
6.7.8.1. Financial Information
6.7.8.2. Future Outlook
6.8. PRS-080 (Pieris Pharmaceuticals)
6.8.1. Overview
6.8.2. History of Development
6.8.3. Mechanism of Action
6.8.4. Technology Overview
6.8.5. Manufacturing Information
6.8.6. Current Status of Development
6.8.7. Clinical Studies
6.8.8. Key Clinical Trial Results
6.8.9. Target Patient Population
6.8.10. Developer Overview: Pieris Pharmaceuticals
6.8.10.1. Financial Information
6.8.10.2. Future Outlook
7. MARKET FORECAST
7.1. Chapter Overview
7.2. Scope and Limitations
7.3. Forecast Methodology
7.4. Overall Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market
7.4.1. Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market: Distribution by Therapeutic Area
7.4.2. Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market: Distribution by End-Use
7.4.3. Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market: Distribution by Non-Antibody Protein Scaffolds
7.4.4. Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market: Distribution by Share of Drugs
7.5. Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market: Individual Drug Forecasts
7.5.1. Kalbitor®
7.5.1.1. Target Patient Population
7.5.1.2. Sales Forecast
7.5.2. Abicipar Pegol / AGN-150998 / MP0112
7.5.2.1. Target Patient Population
7.5.2.2. Sales Forecast
7.5.3. RG6206 / RO7239361 / BMS-986089
7.5.3.1. Target Patient Population
7.5.3.2. Sales Forecast
7.5.4. MP0250 / MP 0250
7.5.4.1. Target Patient Population
7.5.4.2. Sales Forecast
7.5.5. ABY-025 / ABY-002
7.5.5.1. Target Patient Population
7.5.5.2. Sales Forecast
7.5.6. ABY-035 / AFB-035
7.5.6.1. Target Patient Population
7.5.6.2. Sales Forecast
8. RECENT COLLABORATIONS
8.1. Chapter Overview
8.2. Partnership Models
8.3. Non-Antibody Protein Scaffolds: List of Partnerships
8.4. Non-Antibody Protein Scaffolds: Partnership Analysis
8.4.1. Analysis by Year of Partnerships
8.4.2. Analysis by Type of Partnerships
8.4.3. Most Popular Non-Antibody Protein Scaffolds: Analysis by Number of Partnerships
8.4.4. Most Active Companies: Analysis by Number of Partnerships
9. KEY INSIGHTS
9.1. Chapter Overview
9.2. Non-Antibody Protein Scaffolds Pipeline: Potential Targets / Markers
9.3. Non-Antibody Protein Scaffolds Pipeline: Therapeutic Areas
9.4. Non-Antibody Protein Scaffolds Pipeline: Developer Landscape
9.5. Non-Antibody Protein Scaffolds Pipeline: Regional Landscape (Industry Players)
9.6. Non-Antibody Protein Scaffolds Pipeline Leading Players: 3D Bubble Analysis
10. CONCLUSION
10.1. Non-Antibody Protein Scaffolds have Emerged as Viable Alternatives to Monoclonal Antibody based Products
10.2. With One Approved Drug and Multiple Early-Phase Candidates, the Market is Characterized by a Promising Pipeline
10.3. Variety of Product Candidates are Being Developed to Treat a Wide Spectrum of Disease Indications; Oncology is the Key Focus Area
10.4. Both Industry and Academia are Driving the Research Efforts; A Significant Proportion of the Research Activity is Concentrated in Europe
10.5. Several Stakeholders have Entered into Strategic Alliances to Advance Research and Product Development Efforts
10.6. The Approval and Launch of Multiple Late-Phase Product Candidates in the Coming Years is Anticipated to Drive the Future Market Evolution
10.7. Concluding Remarks
11. INTERVIEW TRANSCRIPTS
11.1. Chapter Overview
11.2. Alastair Smith, CEO, Avacta
11.3. Kyu-Tae Kim, Director, AbClon
11.4. Ratmir Derda, Assistant Professor, University of Alberta
11.5. Aditya Pandey, Postdoctoral Fellow, University of Toronto
12. APPENDIX 1: TABULATED DATA
13. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS
Figure 3.1 Basic Structure of an Antibody
Figure 3.2 Revenues of the Top 15 Drugs, 2016 (USD Billion)
Figure 3.3 Antibody Derived Scaffolds: Benefits and Limitations
Figure 3.4 Evolution of Alternative Protein Scaffolds
Figure 3.5 Classification of Non-Antibody Protein Scaffolds
Figure 3.6 Key Benefits of Non-Antibody Protein Scaffolds
Figure 3.7 Types of Target Proteins for Non-Antibody Protein Scaffolds
Figure 3.8 Applications of Non-Antibody Protein Scaffolds
Figure 3.9 Key Therapeutic Areas of Non-Antibody Protein Scaffolds
Figure 4.1 Selection of a Suitable Scaffold: Common Steps
Figure 4.2 Popular Non-Antibody Protein Scaffolds
Figure 4.3 Non-Antibody Protein Scaffolds: Distribution by Scaffold Class
Figure 4.4 Non-Antibody Protein Scaffolds: Distribution by Origin of Parent Protein
Figure 4.5 Non-Antibody Protein Scaffolds: Product Competitiveness Analysis
Figure 4.6 Non-Antibody Protein Scaffolds: Spider-Web Analysis
Figure 5.1 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Phase of Development
Figure 5.2 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by End-Use
Figure 5.3 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Therapeutic Area
Figure 5.4 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Type of Format
Figure 5.5 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Route of Administration
Figure 5.6 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Non-Antibody Protein Scaffold Technology
Figure 5.7 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Leading Players
Figure 6.1 Kalbitor®: Mechanism of Action
Figure 6.2 Kalbitor®: Historical Sales, 2011-H1 2017 (USD Million)
Figure 6.3 Shire: Annual Revenues, 2012-H1 2017 (USD Billion)
Figure 6.4 Dyax: Annual Revenues, 2010-9M 2015 (USD Million)
Figure 6.5 Allergan: Annual Revenues, 2011-H1 2017 (USD Billion)
Figure 6.6 RG6206: Mechanism of Action
Figure 6.7 Roche: Annual Revenues, 2012-H1 2017 (CHF Billion)
Figure 6.8 Affibody: Annual Revenues, 2012-H1 2017 (SEK Million)
Figure 6.9 Multiple Myeloma: Global Epidemiological Distribution
Figure 6.10 Molecular Partners: Annual Revenues, 2011-H1 2017 (CHF Million)
Figure 6.11 PRS-080: Mechanism of Action
Figure 6.12 Pieris Pharmaceuticals: Annual Revenues, 2013-H1 2017 (USD Million)
Figure 7.1 Overall Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market, 2017-2030: Base Scenario (USD Billion)
Figure 7.2 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market (USD Billion), 2017, 2024 and 2030 (Base Scenario): Distribution by Therapeutic Area
Figure 7.3 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market (USD Billion), 2017, 2024 and 2030 (Base Scenario): Distribution by End-Use
Figure 7.4 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market (USD Billion), 2017, 2024 and 2030 (Base Scenario): Distribution by Non-Antibody Protein Scaffold Technology
Figure 7.5 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market (USD Billion), 2017, 2024 and 2030 (Base Scenario): Distribution by Share of Drugs
Figure 7.6 Kalbitor® Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 7.7 Abicipar Pegol Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 7.8 RG6206 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 7.9 MP0250 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 7.10 ABY-025 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 7.11 ABY-035 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 8.1 Non-Antibody Protein Scaffolds Partnerships: Cumulative Trend by Year (2012–2017)
Figure 8.2 Non-Antibody Protein Scaffolds Partnerships: Distribution by Type of Partnership
Figure 8.3 Non-Antibody Protein Scaffolds Partnerships: Most Popular Non-Antibody Protein Scaffold Technology
Figure 8.4 Non-Antibody Protein Scaffolds Partnerships: Most Active Companies
Figure 9.1 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Funnel Analysis: Distribution by Target / Marker and Type of Format
Figure 9.2 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Grid Analysis: Distribution by Therapeutic Area and Phase of Development
Figure 9.3 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Developer Landscape: Distribution by Company Size and Phase of Development
Figure 9.4 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Regional Landscape (Industry Players): Distribution by Company Location and Pipeline Strength
Figure 9.5 Non-Antibody Protein Scaffold Based Drugs / Diagnostic Leading Players: 3D Bubble Analysis Based on Company Size, Strength of Pipeline and Recent Collaborations
Figure 10.1 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market, 2017, 2024, and 2030: Conservative, Base and Optimistic Scenarios (USD Billion)
Table 3.1 Top Ten Therapeutic Antibodies, 2016
Table 3.2 Comparison of Key Characteristics: Monoclonal Antibodies, Antibody-Derived Protein Scaffolds and Non-Antibody Protein Scaffolds
Table 4.1 Non-Antibody Protein Scaffolds: Comparison of Structural Features
Table 4.2 Non-Antibody Protein Scaffolds: Comparison of Pharmacokinetic and Biophysical Features
Table 4.3 Non-Antibody Protein Scaffolds: Spider-Web Analysis (Input Data)
Table 5.1 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Development Pipeline
Table 5.2 List of Terminated / Withdrawn Non-Antibody Protein Scaffold Drugs / Diagnostics
Table 6.1 Non-Antibody Protein Scaffolds: List of Drugs / Diagnostic Agents Profiled
Table 6.2 Kalbitor®: Current Status of Development
Table 6.3 Kalbitor®: Clinical Trials
Table 6.4 Shire: List of Funding Instances and Investors
Table 6.5 Dyax: List of Funding Instances and Investors
Table 6.6 Abicipar Pegol: Current Status of Development
Table 6.7 Abicipar Pegol: Clinical Trials
Table 6.8 Allergan: List of Funding Instances and Investors
Table 6.9 RG6206: Current Status of Development
Table 6.10 RG6206: Clinical Trials
Table 6.11 Roche: List of Funding Instances and Investors
Table 6.12 ABY-025: Current Status of Development
Table 6.13 ABY-025: Clinical Trials
Table 6.14 Affibody: List of Funding Instances and Investors
Table 6.15 ABY-035: Current Status of Development
Table 6.16 ABY-035: Clinical Trials
Table 6.17 MP0250: Current Status of Development
Table 6.18 MP0250: Clinical Trials
Table 6.19 Molecular Partners: List of Funding Instances and Investors
Table 6.20 PRS-080: Current Status of Development
Table 6.21 PRS-080: Clinical Trials
Table 6.22 Pieris Pharmaceuticals: List of Funding Instances and Investors
Table 7.1 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Expected Launch Years of Advanced Stage Drug Candidates
Table 7.2 Kalbitor®: Target Patient Population
Table 7.3 Abicipar Pegol: Target Patient Population
Table 7.4 RG6206: Target Patient Population
Table 7.5 MP0250: Target Patient Population
Table 7.6 ABY-025: Target Patient Population
Table 7.7 ABY-035: Target Patient Population
Table 8.1 Non-Antibody Protein Scaffolds: Recent Partnerships
Table 12.1 Revenues of the Top 15 Drugs, 2016 (USD Billion)
Table 12.2 Non-Antibody Protein Scaffolds: Distribution by Scaffold Class
Table 12.3 Non-Antibody Protein Scaffolds: Distribution by Origin of Parent Protein
Table 12.4 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Phase of Development
Table 12.5 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by End-Use
Table 12.6 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Therapeutic Area
Table 12.7 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Type of Format
Table 12.8 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Route of Administration
Table 12.9 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Non-Antibody Protein Scaffold Technology
Table 12.10 Non-Antibody Protein Scaffold Based Drugs / Diagnostics: Distribution by Leading Players
Table 12.11 Kalbitor®: Historical Sales, 2011-H1 2017 (USD Million)
Table 12.12 Shire: Annual Revenues, 2012-H1 2017 (USD Billion)
Table 12.13 Dyax: Annual Revenues, 2010-9M 2015 (USD Million)
Table 12.14 Allergan: Annual Revenues, 2011-H1 2017 (USD Billion)
Table 12.15 Roche: Annual Revenues, 2012-H1 2017 (CHF Billion)
Table 12.16 Affibody: Annual Revenues, 2012- H1 2017 (SEK Million)
Table 12.17 Molecular Partners: Annual Revenues, 2011-H1 2017 (USD Million)
Table 12.18 Pieris Pharmaceuticals: Annual Revenues, 2013-H1 2017 (USD Million)
Table 12.19 Overall Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market, 2017-2030: Base Scenario (USD Billion)
Table 12.20 Overall Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market, 2017-2030: Optimistic Scenario (USD Billion)
Table 12.21 Overall Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market Conservative Scenario (USD Billion)
Table 12.22 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market (USD Billion), 2017, 2024 and 2030 (Base Scenario): Distribution by Therapeutic Area
Table 12.23 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market (USD Billion), 2017, 2024 and 2030 (Base Scenario): Distribution by End-Use
Table 12.24 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market (USD Billion), 2017, 2024 and 2030 (Base Scenario): Distribution by Non-Antibody Protein Scaffold Technology
Table 12.25 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market (USD Billion), 2017, 2024 and 2030 (Base Scenario): Distribution by Drugs
Table 12.26 Kalbitor® Sales Forecast (Till 2030): Base Scenario (USD Million)
Table 12.27 Kalbitor® Sales Forecast (Till 2030): Optimistic Scenario (USD Million)
Table 12.28 Kalbitor® Sales Forecast (Till 2030): Conservative Scenario (USD Million)
Table 12.29 Abicipar Pegol Sales Forecast (Till 2030): Base Scenario (USD Million)
Table 12.30 Abicipar Pegol Sales Forecast (Till 2030): Optimistic Scenario (USD Million)
Table 12.31 Abicipar Pegol Sales Forecast (Till 2030): Conservative Scenario (USD Million)
Table 12.32 RG6206 Sales Forecast (Till 2030): Base Scenario (USD Million)
Table 12.33 RG6206 Sales Forecast (Till 2030): Optimistic Scenario (USD Million)
Table 12.34 RG6206 Sales Forecast (Till 2030): Conservative Scenario (USD Million)
Table 12.35 MP0250 Sales Forecast (Till 2030): Base Scenario (USD Million)
Table 12.36 MP0250 Sales Forecast (Till 2030): Optimistic Scenario (USD Million)
Table 12.37 MP0250 Sales Forecast (Till 2030): Conservative Scenario (USD Million)
Table 12.38 ABY-025 Sales Forecast (Till 2030): Base Scenario (USD Million)
Table 12.39 ABY-025 Sales Forecast (Till 2030): Optimistic Scenario (USD Million)
Table 12.40 ABY-025 Sales Forecast (Till 2030): Conservative Scenario (USD Million)
Table 12.41 ABY-035 Sales Forecast (Till 2030): Base Scenario (USD Million)
Table 12.42 ABY-035 Sales Forecast (Till 2030): Optimistic Scenario (USD Million)
Table 12.43 ABY-035 Sales Forecast (Till 2030): Conservative Scenario (USD Million)
Table 12.44 Non-Antibody Protein Scaffolds Partnerships: Cumulative Trend by Year (2012–2017)
Table 12.45 Non-Antibody Protein Scaffolds Partnerships: Distribution by Type of Partnership
Table 12.46 Non-Antibody Protein Scaffolds Partnerships: Most Popular Non-Antibody Protein Technology
Table 12.47 Non-Antibody Protein Scaffolds Partnerships: Most Active Companies
Table 12.48 Non-Antibody Protein Scaffold Based Drugs / Diagnostics Market: Conservative, Base and Optimistic Scenario, 2017, 2024 and 2030 (USD Billion)
The following companies and organizations have been mentioned in the report:
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