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Oral Proteins and Peptides Market (3rd Edition), 2018-2030

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  • Published
    March 2018

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Example Insights

  1. Around 100 oral protein / peptide therapeutics are currently being developed across various preclinical / clinical stages for a diverse range of indications. Two products, namely Linzess® (Ironwood Pharmaceuticals) and Trulance® (Synergy Pharmaceuticals), are commercially available; of these, Trulance® was approved in January 2017. Nearly 41% of the pipeline molecules are under clinical development; of these, 8 molecules are being investigated in phase III and phase II/III, 18 molecules in phase II, 5 molecules in phase II (planned), 1 in phase I/II, and 9 molecules in phase I and phase I (planned) clinical trials. However, majority (57%) of the product candidates in the pipeline are still in the preclinical and discovery stages.
  2. 42% of the products in the development pipeline are designed to treat various metabolic disorders, including (in decreasing order of number of pipeline products) diabetes, obesity and non-alcoholic steatohepatitis (NASH). Nearly 15% of therapy candidates are being developed for the treatment of digestive and gastrointestinal disorders, including (in decreasing order of number of pipeline products) chronic idiopathic constipation (CIC), irritable bowel syndrome with constipation (IBS-C), inflammatory bowel disease (IBD) (Crohn's disease and ulcerative colitis), opioid-induced constipation (OIC) and short bowel syndrome (SBS). Products are also being developed for other therapeutic areas, such as autoimmune disorders (9), infectious diseases (9), hormonal disorders (5), bone disorders (4), blood disorders (3), various oncological indications (2), respiratory disorders (2), urogenital disorders (2), genetic disorders (1) and neurodegenerative disorders (1).
  3. The market landscape is characterized by the presence of large (13, with more than 200 employees), mid-sized (12, with50-200 employees) and small-sized companies (33, with less than 50 employees). Some of the prominent large companies engaged in this domain include (in alphabetical order)Chiasma Pharma, Ferring Pharmaceuticals, Ironwood Pharmaceuticals, Novo Nordisk and Sanofi Aventis. Similarly, mid-sized companies that are actively contributing to the development of oral protein / peptide-based product candidates include (in alphabetical order) Emisphere Technologies, Protagonist Therapeutics, Synergy Pharmaceuticals and Transgene Biotek. In addition, small companies, such as (in alphabetical order)Allena Pharmaceuticals, Biolingus, Enteris BioPharma, Longevity Biotech, Oramed Pharmaceuticals, Proxima Concepts and Rani Therapeutics, are also actively involved in this domain.
  4. Several universities / research organizations, either independently or in collaboration with industry players, have also contributed to the development of products in both preclinical and clinical studies. Examples include (in alphabetical order) Medical University of South Carolina, Monash University, National Institute of Diabetes and Digestive and Kidney Diseases, Niagara University and University of Montreal.
  5. To overcome the challenges related to the effective administration of oral biologics, several innovative technologies to formulate and deliver oral biologics are being developed. Notable examples of advanced drug delivery technologies include (in decreasing order of number of pipeline products) Robotic Pill Maker technology (Rani Therapeutics), Peptelligence® (Enteris BioPharma), AxcessTM oral drug delivery technology (Proxima Concepts), Oral Peptide Utility System (OPUS) technology (Biolingus), Sublingual Immunotherapy (SLIT) technology (Biolingus), and Oramed Protein Oral Delivery (PODTM) technology (Oramed Pharmaceuticals).
  6. Over 195 funding instances, amounting to USD 5.4 billion worth of capital, have taken place in this field in the last decade. Cherrystone Angel Group, Novartis Venture Fund, Third Security, MVM Life Science Partners, Venrock, ARCH Venture Partners, Ascent Biomedical Ventures, Boston Harbor Angels, F2 Ventures, Google Ventures, MPM Capital and Pharmstandard Internationalhave emerged as some of the prominent investors (in terms of number of funding instances).
  7. Since 2008, around 100 partnerships have been inked between various stakeholders within the industry; of these, 44 collaborations have been established since 2012. Approximately 39% of the deals were product development / commercialization agreements; recent examples include agreements between Carmot Therapeutics and Amgen (December 2017), Eli Lilly and KeyBioscience (June 2017), Protagonist Therapeutics and Janssen Biotech (May 2017), Enteris BioPharma and Sanofi (January 2017), Ironwood Pharmaceuticals and Allergan (January 2017), and Takeda Pharmaceuticals and PvP Biologics (January 2017). Other popular types of collaborations were R&D deals (25%), technology licensing agreements (9%), manufacturing agreements (8%), mergers / acquisitions (7%), product licensing agreements (6%) and clinical trial collaborations (5%). In terms of the number of deals signed in the given time period, Oramed Pharmaceuticals (8), Ironwood Pharmaceuticals (8), Merrion Pharmaceuticals (7), Enteris BioPharma (7) and Novo Nordisk (7), have emerged as the most active companies.
  8. With many candidates in late stages of development and increase in technological advancements, the market is likely to grow at a steady pace over the coming decade. North America and the EU5 presently dominate the market share and are expected to retain the leading position over the next decade. Within Asia-Pacific and RoW regions, India, Japan, Russia, Israel and Australia are expected to garner a growing share of the market by 2030.
  9. The two currently marketed drugs target digestive and gastrointestinal disorders, including CIC and IBS-C. With the anticipated approval of close to 20 additional drugs by 2030, the market is likely to be driven by five therapeutic areas, namely digestive and gastrointestinal disorders (31%), metabolic disorders (30%), bone disorders (10%), infectious diseases (6%) and urogenital disorders (5.5%). In fact, specific products, being developed for indications with very large target patient populations, are anticipated to achieve blockbuster status (with sales over USD 1 billion) and become prime contributors to future revenues in the coming decade.

 

Overview

The field of oral proteins / peptides has enormous opportunities. I believe the field will continue to grow at a rapid pace considering the healthy clinical pipeline of oral proteins / peptides.

-Chief Executive Officer, US based small-sized developer

Protein and peptide-based therapeutics have been in use for more than three decades since the approval of recombinant human insulin, the first protein therapy, in 1982. Earlier, most biologic drugs were delivered through the subcutaneous route. However, over time, advances in delivery formulations have enabled the development of orally administrable versions of therapeutic proteins / peptides. Owing to numerous compelling reasons, the concept of oral delivery has gained significant traction. The first oral protein / peptide-based product candidate, Linzess ®, was launched in 2012 in the US and EU. Recently, Trulance ®, another orally administrable product was approved in the US (January 2017) for the treatment of chronic idiopathic constipation (CIC). In fact, in January 2018, Trulance® was approved for another indication, namely irritable bowel syndrome with constipation (IBS-C).

The growing popularity of this upcoming class of therapeutics has led to the development of several oral protein / peptide-based product candidates for the treatment of a myriad of diseases. In addition, the need for efficient and patient-friendly treatment options for chronic disorders, such as diabetes, is estimated to boost the demand for oral proteins and peptides in the coming years. Despite their clinical and commercial success, oral formulations of protein / peptide-based drugs have been associated with multiple drawbacks, such as concerns related to unwanted enzymatic degradation, inherent structural complexities, high manufacturing costs and low bioavailability. The aforementioned issues tend to have an impact on the overall efficacy of such products, thereby, limiting their therapeutic potential. This has prompted researchers to develop better technologies in order to improve product stability and therapeutic efficiency. The ongoing innovation has led to the discovery of novel biological targets, strengthening the research pipelines of various companies focused in this domain. Increasing research and development activities, and rising demand for effective drugs with better therapy adherence profiles are anticipated to encourage growth of the global oral proteins and peptides market in the coming years.

Scope of the Report

The ‘Oral Proteins and Peptides Market (3rd Edition), 2018-2030’ report provides an extensive study on the current market landscape of orally administrable protein / peptide-based therapeutics, featuring a comprehensive discussion on the future potential of this evolving market. The field has captured the interest of several drug developers, including both small to mid-sized players and large companies. While more than half of these pipeline candidates are in the discovery / preclinical stages, around 28% of drug candidates are presently in advanced stages of evaluation (phase II and above). Amongst other elements, the report features:

  • A detailed assessment of the current market landscape of oral proteins / peptides, providing information on various drug developers, phase of development (clinical, preclinical or discovery stage) of product candidates, type of molecule (protein or peptide), biological target, mechanism of action, affiliated technology platform, key therapeutic area(s) and indication(s), and dosage.
  • An in-depth analysis of the product pipeline and developer companies, featuring three schematic representations; these include [A] a four dimensional grid analysis, representing the distribution of oral proteins / peptides (on the basis of the type of molecule) across various target therapeutic areas and stages of development, [B] a logo landscape of the various industry and non-industry players involved in the development of oral protein / peptide-based drugs, distributed on the basis of phase of development of pipeline candidates and size of developer companies (small-sized, mid-sized and large companies), and [C] a schematic world map representation, highlighting the most active geographies, in terms of the presence of various industry players that are involved in the development of oral proteins / peptides.
  • Details of recently held / upcomingconferences focused solely / partially on various aspects related to the oral delivery of proteins / peptides.
  • A detailed analysis identifying the key opinion leaders (KOLs) in the field of oral proteins / peptides. This features a 2X2 analysis to assess the relative experience of certain KOLs, who were shortlisted based on their contributions (in terms of involvement in various clinical studies) to this field, and a schematic world map representation, highlighting the geographical locations of eminent scientists / researchers involved in the development of already marketed molecules in this domain.
  • Identification of the most commonly targeted therapeutic indications, and details of the oral proteins / peptides being developed against them. The study presents information on epidemiology, available diagnostic tests, and details of current treatment options and their side effects.
  • Comprehensive profiles of marketed and phase III drugs, highlighting their history of development, mechanism of action, dosage information (if available), manufacturing information (if available), current status of development, clinical trial information, key clinical trial results, historical sales (if marketed) and information on the developer.
  • A case study, featuring profiles of three of the most popular orally administrable protein / peptide-based drugs belonging to other drug classes, namely cyclic peptides and pancreatic enzyme replacement therapies (PERTs), which are either commercialized or under development. Each profile provides an overview of the drug, history of development, chemical structure and mechanism of action, dosage information (if marketed), clinical trial information (if the product is currently under development), patent portfolio (if available), and information on the other commercially available treatment options.
  • A review of the various oral drug delivery technology platforms that are being used for the development of product candidates in this domain, highlighting their key features and providing information on their developers. Specifically, for each technology platform, we have captured information on the various components of the technology, approach / system being used, type of formulation and type of molecules(s) that can be delivered using the technology.
  • Elaborate profiles of the technologies that are presently being used in the development of three or more products / product candidates (in both preclinical and clinical stages of development) with at least one candidate in the clinical stages of development, along with technologies for which the drugs are in advanced clinical stages of development (phase III and above). Each profile features an overview of the developer and technology, mechanism of action, key advantages, pipeline molecules developed using the technology and recent developments specific to the technology (acquisitions / mergers, collaborations and expansions). 
  • An insightful 2X2 analysis of the different oral delivery technology platforms that are presently being utilized for the generation of oral proteins / peptides. The analysis is based on the supplier power (represented in terms of venture funding activity and company size) and product competitiveness (represented in terms of development activity (number of drugs in both preclinical / clinical stages of development), indication coverage, partnerships activity).
  • An analysis of the partnerships that have been established in the recent past, covering product development / commercialization agreements, R&D collaborations, technology licensing deals, manufacturing agreements, merger / acquisitions, product licensing deals, clinical trial collaborations and others.
  • An analysis of the investments made at various stages of development in companies that are focused in this area, including seed financing, venture capital financing, debt financing, grants, capital raised from IPOs and subsequent offerings.
  • A publication analysis, featuring inputs from close to 90 articles that have been published in 2017, highlighting the key focus areas of the ongoing research activity in this field.
  • An analysis depicting the prevalent and emerging trends related to this domain as represented on the social media platform, Twitter. In addition to providing information on quarterly trends related to the volume of tweets in 2017, the analysis highlights the most talked about biological targets, drug candidates, active players, technology platforms, disease indications, and therapeutic areas.
  • A detailed case study on protein / peptide contract manufacturing, featuring a list of over 140 CMOs that are currently offering contract manufacturing services for such products / product candidates.
  • A discussion on affiliated trends, key drivers and challenges, under a SWOT framework. The analysis features a Harvey ball analysis, highlighting the relative effect of each SWOT parameter on the overall oral proteins / peptides market.

One of the key objectives of this study was to understand the primary growth drivers and estimate the future size of the market. Based on parameters, such as target consumer segments, likely adoption rates and expected pricing, we have provided an informed estimate of the likely evolution of the market in the short to mid-term and long term, for the period 2018-2030. In addition, we have provided the likely distribution of the market based on [A] therapeutic areas (autoimmune disorders, bone disorders, digestive and gastrointestinal disorders, hormonal disorders, infectious diseases, metabolic disorders, urogenital disorders and others), [B] molecule type (protein and peptide), [C] technology platforms, [D] key players, and [E] geography (North America (the US, Canada and Mexico), Europe (EU5 countries), Asia-Pacific and RoW). To account for the uncertainties associated with the growth of the oral proteins / peptides market and to add robustness to our model, we have provided three forecast scenarios, portraying conservative, base and optimistic tracks of the market’s evolution.

The research, analysis and insights presented in this report is backed by a deep understanding of insights gathered both from secondary and primary sources. This enabled us to solicit inputs on upcoming opportunities and challenges that were considered to develop estimates for a more inclusive growth. The opinions and insights presented in this study were influenced by discussions conducted with several key players in this domain. The report features detailed transcripts of interviews held with Dinesh Srinivasan (Director, Anthera Pharmaceuticals), Stig K Hansen (Co-founder and CEO, Carmot Therapeutics), Terry Dyck (CEO, IGY Life Sciences and Technology) and Richard Franklin (Director and CEO, Tarix Orphan). All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

Contents

Chapter Outlines

Chapter 2  provides an executive summary of the insights captured in our research. The summary offers a high-level view on the likely evolution of oral proteins / peptides market, in the short-mid term and long term.

Chapter 3  provides a comparison of the key characteristics of small molecules and large molecules / biologics. Further, it includes a detailed discussion on proteins / peptides, highlighting their potential as therapeutic agents. It also features a discussion on the various routes of administration used for the delivery of drugs, with special focus on oral route. The chapter elaborates on the likely advantages and challenges associated with the oral route of administration. In addition, it includes a comprehensive discussion on the various approaches developed / under development for the effective oral delivery of proteins / peptides.

Chapter 4  includes information on 100 oral proteins / peptides that are currently approved / under development for therapeutic use. It features a comprehensive analysis of pipeline molecules, highlighting the drug developers, phases of development, type of molecule (protein and peptide), biological target, technology platforms, target therapeutic area(s) and disease indication(s). The chapter also highlights the various oral proteins / peptides that have been discontinued over the last few years.

Chapter 5  presents the key insights derived from the study. It features a four-dimensional grid analysis, representing the distribution of product candidates (on the basis of type of molecule) across various target therapeutic areas and stages of development. In addition, it features a logo landscape of industry and non-industry players that are engaged in the development of oral proteins / peptides, distributed based on the developmental status of pipeline candidates and size of companies (small-sized, mid-sized and large companies). We have also mapped the geographical presence of various industry players that are involved in the development of product candidates in this field. In addition, the chapter provides a list of recently-held / upcoming conferences focused on various aspects related to the oral delivery of proteins / peptides.

Chapter 6  provides an analysis of the KOLs in the field of oral proteins / peptides. It provides a comprehensive list of principal investigators of different clinical trials, along with information related to the affiliated research institutes. The chapter features a schematic representation on a world map, highlighting the geographical locations of the eminent scientists / researchers who are engaged in clinical research activity in this domain.It also features a comparative analysis, highlighting those KOLs who have relatively more experience in this domain.

Chapter 7  highlights the potential target indications (segregated by therapeutic areas) that are currently the prime focus of companies developingoral proteins / peptides. These include metabolic disorders, digestive and gastrointestinal disorders, infectious diseases, autoimmune disorders, hormonal disorders and bone disorders. The chapter also provides details on disease epidemiology, available diagnostic tests, and currently available treatment options for each indication and their likely side effects.

Chapter 8  contains detailed profiles of drugs that are either marketed or are in phase III of development. Each profile features an overview of the drug, history of development, mechanism of action, dosage information  (if available), manufacturing information  (if available),  current status of development, clinical trial information, key clinical trial results, historical sales  (if marketed)  and information on the developer.

Chapter 9  provides a review of oral proteins / peptides belonging other drug classes, namely cyclic peptides and PERTs, which are either commercialized or still under development. The chapter features detailed profiles of three popular orally administrable, therapeutic proteins / peptides (Minirin®, Sandimmune® and Sollpura®), which were discovered before 2000. Each profile contains an overview of the drug, history of development, chemical structure and mechanism of action, dosage information  (if marketed ), clinical trial information ( if the product is currently under development ), patent portfolio  (if available ) and information on the other commercially available treatment options for the disease indications for which each drug is approved.

Chapter 10  provides a list of technology platforms that are either currently available, or being developed by various firms, for the generation of oral proteins / peptides with information on technology composition, approach / system being used, formulation and type of molecules(s) that can be delivered using the technology. In addition, it features detailed profiles of some of the key technologies that have been used to develop (at least three) clinical and / or preclinical product candidates, along with the technologies for which the drugs are in advanced clinical stages of development (phase III and above). Each profile contains details on the technology, including mechanism of action, pipeline molecules developed using the technology, its advantages and the various partnerships that were established related to the technology.

Chapter 11  features a 2X2 matrix, comparing product competitiveness and supplier power of the oral drug delivery technology platforms that are presently being utilized for the generation of oral proteins / peptides. The analysis takes into consideration several parameters, such as venture funding activity, company size, development activity (number of drugs in both preclinical / clinical stages of development), indication coverage and partnerships activity.

Chapter 12  presents details on various investments received by companies that are engaged in this domain. It also includes an analysis of the funding instances that have taken place in the period between 1996 and January 2018, highlighting the growing interest of the venture capital community and other strategic investors in this market.

Chapter 13  features an elaborate discussion and analysis of the various collaborations and partnerships that have been inked amongst players in this market. We have also discussed the different partnership models (including product development / commercialization agreements, R&D agreements, technology licensing, manufacturing agreement, mergers / acquisitions, product licensing, clinical trial collaborations and others) and the most common forms of deals / agreements that have been established between stakeholders in this domain between 2000 and 2018 (till January).

Chapter 14  provides a comprehensive publication analysis, highlighting the recent trends in published literature related to oral proteins / peptides. It presents information such as the year of publication, type of study, the key targets and the publication journals. The chapter provides details on novel methods, and also highlights the various attempts that are being made to add value to the ongoing R&D efforts within this domain.

Chapter 15  provides insights on the popularity of oral proteins / peptides on the social media platform, Twitter. The section highlights the yearly distribution of tweets posted on the platform in the time period 2013-2017, and the most significant events responsible for increase in the volume of tweets each year. Additionally, the chapter showcases the most frequently mentioned words, therapeutic areas, biological targets, drug candidates, and the key players that post frequent updates related to their drugs and technologies, as observed on social media.

Chapter 16  presents a comprehensive market forecast analysis, highlighting the future potential of the market till the year 2030. It includes future sales projections of drugs that are either marketed or in advanced stages of clinical development (phase II and above). Further, sales potential and growth opportunity were estimated based on target patient population, likely adoption rates, existing / future competition from other drugs and the likely price of products. The chapter also presents a detailed market segmentation on the basis of therapeutic areas (autoimmune disorders, bone disorders, digestive and gastrointestinal disorders, hormonal disorders, infectious diseases, metabolic disorders, urogenital disorders and others), molecule type (protein and peptide), technology platforms, key players, and geography (North America (the US, Canada and Mexico), Europe (EU5 countries), Asia-Pacific and RoW).

Chapter 17  features a case study on the role of CMOs in the field of oral proteins / peptides. It provides details on the various factors that need to be considered while selecting the right CMO partner for the pharmaceutical companies. In addition, it includes a list of over 140 contract manufacturers that claim to have the necessary capabilities for protein / peptide manufacturing.

Chapter 18  provides a detailed analysis capturing the key parameters and trends that are likely to influence the future of the oral proteins / peptides market, under a comprehensive SWOT framework.The chapter also features a schematic Harvey ball analysis to highlight the relative impact of each SWOT parameter on the overall oral proteins / peptides market.

Chapter 19  is a summary of the overall report. In this chapter, we have provided a list of the key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.

Chapter 20  is a collection of interview transcripts of discussions held with key stakeholders in this market. In this chapter, we have presented the details of our conversations with Dinesh Srinivasan (Director, Anthera Pharmaceuticals), Stig K Hansen (Co-founder and CEO, Carmot Therapeutics), Terry Dyck (CEO, IGY Life Sciences and Technology) and Richard Franklin (Director and CEO, Tarix Orphan).

Chapter 21  is an appendix, which provides tabulated data and numbers for all the figures provided in the report.

Chapter 22  is an appendix, which provides the list of companies and organizations mentioned in the report.

Table of Contents

1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
 
2. EXECUTIVE SUMMARY
 
3. INTRODUCTION
3.1. Chapter Overview
3.2. Comparison of Biologics and Small Molecules
3.3. An Introduction to Proteins
3.3.1. Protein Structure
3.3.2. Classification

 

 

3.4. An Introduction to Peptides
3.4.1. Peptide Structure
3.4.2. Classification
3.4.2.1. Synthetic Peptides
3.4.2.2. Recombinant Peptides

 

3.5. Routes of Delivery for Proteins / Peptides
3.5.1. Parenteral Systemic Delivery
3.5.1.1. Intramuscular Route
3.5.1.2. Intravenous Route
3.5.1.3. Subcutaneous Route
3.5.2. Non-Parenteral Delivery
3.5.2.1. Buccal / Sublingual Route
3.5.2.2. Intranasal Route
3.5.2.3. Oral Route
3.5.2.4. Ocular Route
3.5.2.5. Pulmonary Route / Inhalation
3.5.2.6. Rectal Route
3.5.2.7. Transdermal Route
3.5.3. Comparison of Different Routes of Drug Delivery

3.6. Oral Delivery of Proteins / Peptides
3.6.1. Key Advantages of Oral Delivery
3.6.2. Key Challenges Associated with Oral Delivery

3.7. Approaches Used for Structural and Bioavailability Enhancement
3.7.1. Absorption Enhancers
3.7.2. Chemical Modification
3.7.3. Enzyme Inhibitors
3.7.4. Muco-Adhesive Polymeric Systems
3.7.5. Nanoparticular Delivery Systems
3.7.5.1. Liposomes
3.7.5.2. Nanoparticles / Microparticles
3.7.6. PEGylation

3.8. Concluding Remarks

4. MARKET OVERVIEW
4.1. Chapter Overview
4.2. Oral Proteins / Peptides: Development Pipeline
4.2.1. Distribution by Phase of Development
4.2.2. Distribution by Type of Molecule
4.2.3. Distribution by Therapeutic Areas
4.2.4. Distribution by Key Biological Targets
4.2.5. Distribution by Key Technology Platforms
4.2.6. Distribution by Leading Players

4.3. Oral Proteins / Peptides: Terminated / Discontinued Candidates

5. KEY INSIGHTS
5.1. Chapter Overview
5.2. Oral Proteins / Peptides Pipeline: Target Therapeutic Areas
5.3. Oral Proteins / Peptides Pipeline: Developer Landscape
5.4. Oral Proteins / Peptides Pipeline: Regional Landscape (Industry Players)
5.5. Oral Proteins / Peptides: Recent / Upcoming Conferences

6. KOL ANALYSIS
6.1. Chapter Overview
6.2. Current Research Landscape
6.3. Linzess® and Trulance ®: Key Opinion Leaders
6.4. Most Prominent Key Opinion Leaders

7. KEY THERAPEUTIC AREAS
7.1. Chapter Overview
7.2.Metabolic Disorders
7.2.1. Diabetes
7.2.1.1. Disease Description
7.2.1.2. Associated Health Risks / Complications
7.2.1.3. Epidemiology
7.2.1.4. Disease Diagnosis
7.2.1.5. Current Treatment Options
7.2.1.5.1. Insulin Therapies
7.2.1.5.2. Non-Insulin Therapies
7.2.1.6. Side Effects of Current Treatment Options
7.2.1.7. Oral Proteins / Peptides for Diabetes
7.2.2. Obesity
7.2.2.1. Disease Description
7.2.2.2. Epidemiology
7.2.2.3. Current Treatment Options
7.2.2.4. Side Effects of Current Treatment Options
7.2.2.5. Oral Proteins / Peptides for Obesity
7.2.3. Non-alcoholic Steatohepatitis (NASH)
7.2.3.1. Disease Description
7.2.3.2. Epidemiology
7.2.3.3. Current Treatment Options
7.2.3.4. Oral Proteins / Peptides for NASH

7.3.  Digestive and Gastrointestinal Disorders
7.3.1. Ulcerative Colitis
7.3.1.1. Disease Description
7.3.1.2. Epidemiology
7.3.1.3. Current Treatment Options
7.3.1.4. Side Effects of Current Treatment Options
7.3.1.5. Oral Proteins / Peptides for Ulcerative Colitis
7.3.2. Crohn’s Disease
7.3.2.1. Disease Description
7.3.2.2. Epidemiology
7.3.2.3. Current Treatment Options
7.3.2.4. Side Effects of Current Treatment Options
7.3.2.5. Oral Proteins / Peptides for Crohn’s Disease

7.4. Infectious Diseases
7.4.1. C. difficile Infections (CDIs)
7.4.1.1. Disease Description
7.4.1.2. Epidemiology
7.4.1.3. Disease Diagnosis
7.4.1.4. Current Treatment Options
7.4.1.5. Side Effects of Current Treatment Options
7.4.1.6. Oral Proteins / Peptides for CDIs

7.5. Autoimmune Disorders
7.5.1. Celiac Disease
7.5.1.1. Disease Description
7.5.1.2. Epidemiology
7.5.1.3. Disease Diagnosis
7.5.1.4. Current Treatment Options
7.5.1.5. Oral Proteins / Peptides for Celiac Disease

7.6. Hormonal Disorders
7.6.1. Acromegaly
7.6.1.1. Disease Description
7.6.1.2. Epidemiology
7.6.1.3. Disease Diagnosis
7.6.1.4. Current Treatment Options
7.6.1.5. Side Effects of Current Treatment Options
7.6.1.6. Oral Proteins / Peptides for Acromegaly

7.7. Bone Disorders
7.7.1. Osteoporosis
7.7.1.1. Disease Description
7.7.1.2. Epidemiology
7.7.1.3. Disease Diagnosis
7.7.1.4. Current Treatment Options
7.7.1.5. Side Effects of Current Treatment Options
7.7.1.6. Oral Proteins / Peptides for Osteoporosis

8. MARKETED AND LATE-STAGE DRUG PROFILES
8.1. Chapter Overview
8.2. Linzess® / Constella®  / Linaclotide (Ironwood Pharmaceuticals)
8.2.1. Overview
8.2.2. History of Development
8.2.3. Mechanism of Action
8.2.4. Dosage Form, Treatment Regimen and Price
8.2.5. Manufacturing Information
8.2.6. Current Status of Development
8.2.7. Clinical Studies
8.2.8. Key Clinical Trial Results
8.2.9. Historical Sales
8.2.10. Developer Overview

8.3. Trulance® / Plecanatide (Synergy Pharmaceuticals)
8.3.1. Overview
8.3.2. History of Development
8.3.3. Mechanism of Action
8.3.4. Dosage Form, Treatment Regimen and Price
8.3.5. Manufacturing Information
8.3.6. Current Status of Development
8.3.7. Clinical Studies
8.3.8. Key Clinical Trial Results
8.3.9. Historical Sales
8.3.10. Developer Overview

8.4. TBRIA™ / OSTORA / Oral Calcitonin (Tarsa Therapeutics / Enteris BioPharma)
8.4.1. Overview
8.4.2. History of Development
8.4.3. Mechanism of Action
8.4.4. Manufacturing Information
8.4.5. Current Status of Development
8.4.6. Clinical Studies
8.4.7. Key Clinical Trial Results
8.4.8. Developer Overview

8.5. ALLN-177 (Allena Pharmaceuticals)
8.5.1. Overview
8.5.2. History of Development
8.5.3. Mechanism of Action
8.5.4. Current Status of Development
8.5.5. Clinical Studies
8.5.6. Key Clinical Trial Results
8.5.7. Developer Overview

8.6. Mycapssa™ / Octreolin / Oral Octreotide (Chiasma Pharma)
8.6.1. Overview
8.6.2. History of Development
8.6.3. Mechanism of Action
8.6.4. Manufacturing Information
8.6.5. Current Status of Development
8.6.6. Clinical Studies
8.6.7. Key Clinical Trial Results
8.6.8. Developer Overview

8.7. NTRA-2112 (Nutrinia)
8.7.1. Overview
8.7.2. Mechanism of Action
8.7.3. Current Status of Development
8.7.4. Clinical Studies
8.7.5. Developer Overview

8.8. Oral Semaglutide / NN9924 / OG217SC (Novo Nordisk / Emisphere Technologies)
8.8.1. Overview
8.8.2. History of Development
8.8.3. Mechanism of Action
8.8.4. Manufacturing Information
8.8.5. Current Status of Development
8.8.6. Clinical Studies
8.8.7. Key Clinical Trial Results
8.8.8. Developer Overview

9. CASE STUDIES: MINIRIN ®, SANDIMMUNE®, AND SOLLPURA®
9.1. Chapter Overview
9.2. Minirin ® / DDAVP (Ferring Pharmaceuticals)
9.2.1. Overview
9.2.2. History of Development
9.2.3. Chemical Structure and Mechanism of Action
9.2.4. Dosage Form, Treatment Regimen and Price
9.2.5. Patent Portfolio
9.2.6. Competitive Landscape

9.3. Sandimmune ® / Neoral ® (Novartis)
9.3.1. Overview
9.3.2. History of Development
9.3.3. Mechanism of Action
9.3.4. Dosage Form, Treatment Regimen and Price
9.3.5. Patent Portfolio
9.3.6. Competitive Landscape

9.4. Sollpura ® / Liprotamase (Anthera Pharmaceuticals)
9.4.1. Overview
9.4.2. History of Development
9.4.3. Chemical Structure and Mechanism of Action
9.4.4. Current Status of Development
9.4.5. Clinical Studies
9.4.6. Competitive Landscape

10. ORAL DRUG DELIVERY TECHNOLOGY PLATFORMS
10.1. Chapter Overview
10.2. Oral Drug Delivery: List of Technology Platforms
10.3. Technology Profiles
10.3.1. Axcess™ Oral Drug Delivery Technology (Proxima Concepts)
10.3.1.1. Developer Overview
10.3.1.2. Technology Overview
10.3.1.3. Drug Delivery Mechanism
10.3.1.4. Key Advantages
10.3.1.5. Oral Proteins / Peptides Pipeline
10.3.1.6. Collaborations

10.3.2. Eligen™ Technology (Emisphere Technologies)
10.3.2.1. Developer Overview
10.3.2.2. Technology Overview
10.3.2.3. Drug Delivery Mechanism
10.3.2.4. Key Advantages
10.3.2.5. Oral Proteins / Peptides Pipeline
10.3.2.6. Collaborations

10.3.3. Entera Technology (Entera Bio)
10.3.3.1. Developer Overview
10.3.3.2. Technology Overview
10.3.3.3. Drug Delivery Mechanism
10.3.3.4. Key Advantages
10.3.3.5. Oral Proteins / Peptides Pipeline

10.3.4. NTRA Oral Delivery Technology (Nutrinia)
10.3.4.1. Developer Overview
10.3.4.2. Technology Overview
10.3.4.3. Drug Delivery Mechanism
10.3.4.4. Key Advantages
10.3.4.5. Oral Proteins / Peptides Pipeline

10.3.5. Peptelligence® Technology (Enteris BioPharma)
10.3.5.1. Developer Overview
10.3.5.2. Technology Overview
10.3.5.3. Drug Delivery Mechanism
10.3.5.4. Key Advantages
10.3.5.5. Oral Proteins / Peptides Pipeline
10.3.5.6. Collaborations

10.3.6. Protein Oral Delivery (POD™) Technology (Oramed Pharmaceuticals)
10.3.6.1. Developer Overview
10.3.6.2. Technology Overview
10.3.6.3. Drug Delivery Mechanism
10.3.6.4. Key Advantages
10.3.6.5. Oral Proteins / Peptides Pipeline

10.3.7. Transient Permeability Enhancer (TPE) Technology (Chiasma Pharma)
10.3.7.1. Developer Overview
10.3.7.2. Technology Overview
10.3.7.3. Drug Delivery Mechanism
10.3.7.4. Key Advantages
10.3.7.5. Oral Proteins / Peptides Pipeline

10.3.8. Uroguanylin Analogue Technology (Synergy Pharmaceuticals)
10.3.8.1. Developer Overview
10.3.8.2. Technology Overview
10.3.8.3. Drug Delivery Mechanism
10.3.8.4. Key Advantages
10.3.8.5. Oral Proteins / Peptides Pipeline

11. PRODUCT COMPETITIVENESS ANALYSIS
11.1. Chapter Overview
11.2. Scope and Methodology
11.3. Product Competitiveness Analysis: Key Technologies

12. FUNDING AND INVESTMENT ANALYSIS
12.1. Chapter Overview
12.2. Types of Funding
12.3. Oral Proteins / Peptides: Funding and Investment Analysis
12.3.1. Analysis by Cumulative Number of Funding Instances
12.3.2. Analysis by Cumulative Amount Invested
12.3.3. Analysis by Type of Funding
12.3.4. Analysis by Most Active Players
12.3.5. Analysis by Most Active Investors
12.4. Concluding Remarks

13. RECENT COLLABORATIONS
13.1. Chapter Overview
13.2. Partnership Models
13.3. Oral Proteins / Peptides: List of Partnerships
13.4. Partnership Analysis
13.4.1. Analysis by Year of Partnerships
13.4.2. Analysis by Type of Partnerships
13.4.3. Most Active Players: Analysis by Number of Partnerships

14. PUBLICATION ANALYSIS
14.1. Chapter Overview
14.2. Oral Proteins / Peptides: List of Publications, 2017
14.2.1. Quarter-Wise Trend (Q1-Q4 2017)
14.2.2. Analysis by Type of Study
14.2.3. Analysis by Key Biological Targets
14.2.4. Analysis by Key Journals

15. EMERGING TRENDS ON SOCIAL MEDIA
15.1. Chapter Overview
15.2. Oral Proteins / Peptides: Trends on Twitter
15.3. Year-Wise Activity Analysis (2013-2017)
15.4. Popular Keywords
15.5. Popular Therapeutic Areas
15.6. Popular Biological Targets
15.7. Popular Technology Platforms
15.8. Popular Drugs
15.9. Popular Players

16. MARKET FORECAST AND OPPORTUNITY ANALYSIS
16.1. Chapter Overview
16.2. Scope and Limitations
16.3. Forecast Methodology
16.4. Overall Oral Proteins / Peptides Market, 2018-2030
16.4.1. Oral Proteins / Peptides Market: Distribution by Therapeutic Area
16.4.2. Oral Proteins / Peptides Market: Distribution by Molecule Type
16.4.3. Oral Proteins / Peptides Market: Distribution by Technology Platforms
16.4.4. Oral Proteins / Peptides Market: Distribution by Geography
16.5. Oral Proteins / Peptides Market: Product-Wise Sales Forecasts

16.5.1. Linzess® / Constella® / Linaclotide (Ironwood Pharmaceuticals)
16.5.1.1. Target Patient Population
16.5.1.2. Sales Forecast

16.5.2. Trulance® / Plecanatide (Synergy Pharmaceuticals)
16.5.2.1. Target Patient Population
16.5.2.2. Sales Forecast

16.5.3. TBRIA™ / OSTORA / Oral Calcitonin (Tarsa Therapeutics / Enteris BioPharma)
16.5.3.1. Target Patient Population
16.5.3.2. Sales Forecast

16.5.4. ALLN-177 (Allena Pharmaceuticals)
16.5.4.1. Target Patient Population
16.5.4.2. Sales Forecast

16.5.5. Mycapssa™ / Octreolin (Chiasma Pharma)
16.5.5.1. Target Patient Population
16.5.5.2. Sales Forecast

16.5.6. NTRA-2112 (Nutrinia)
16.5.6.1. Target Patient Population
16.5.6.2. Sales Forecast

16.5.7. Oral Semaglutide / NN9924 / OG217SC (Novo Nordisk / Emisphere Technologies)
16.5.7.1. Target Patient Population
16.5.7.2. Sales Forecast

16.5.8. Larazotide INN-202 (Innovate Biopharmaceuticals)
16.5.8.1. Target Patient Population
16.5.8.2. Sales Forecast

16.5.9. NTRA-9620 (Nutrinia)
16.5.9.1. Target Patient Population
16.5.9.2. Sales Forecast

16.5.10. AG013 (Oragenics / Intrexon)
16.5.10.1. Target Patient Population
16.5.10.2. Sales Forecast

16.5.11. IMM-124E (Immuron)
16.5.11.1. Target Patient Population
16.5.11.2. Sales Forecast

16.5.12. OPRX-106 (Protalix Biotherapeutics)
16.5.12.1. Target Patient Population
16.5.12.2. Sales Forecast

16.5.13. KORSUVATM / Oral CR845 / Difelikefalin (Enteris BioPharma / Cara Therapeutics)
16.5.13.1. Target Patient Population
16.5.13.2. Sales Forecast

16.5.14. Oral HDV Insulin (Diasome Pharmaceuticals)
16.5.14.1. Target Patient Population
16.5.14.2. Sales Forecast

16.5.15. ORMD-0801 (Oramed Pharmaceuticals)
16.5.15.1. Target Patient Population
16.5.15.2. Sales Forecast

16.5.16. Oshadi Icp Oral Insulin (Oshadi Drug Administration)
16.5.16.1. Target Patient Population
16.5.16.2. Sales Forecast

16.5.17. Ovarest® / Oral Leuprolide Tablet (Enteris BioPharma)
16.5.17.1. Target Patient Population
16.5.17.2. Sales Forecast

16.5.18. SYN-004 / Ribaxamase (Synthetic Biologics)
16.5.18.1. Target Patient Population
16.5.18.2. Sales Forecast

16.5.19. V565 (VHsquared)
16.5.19.1. Target Patient Population
16.5.19.2. Sales Forecast

17. CASE STUDY: PROTEIN / PEPTIDE MANUFACTURING
17.1. Chapter Overview
17.2. Key Steps Involved in Protein / Peptide Manufacturing
17.3. Challenges Associated with Protein / Peptide Manufacturing
17.4. Current Scenario of Protein / Peptide Manufacturing
17.5. Growing Demand for Contract Manufacturing
17.5.1. Selecting A Suitable CMO Partner
17.5.2. List of Protein / Peptide CMOs

18. SWOT ANALYSIS
18.1. Chapter Overview
18.2. Comparison of SWOT Factors

19. CONCLUSION
19.1. Advances in Oral Drug Delivery have Enabled the Development of Protein / Peptide Therapeutics Offering Improved Patient Compliance
19.2. The Field is Characterized by a Promising Development Pipeline, Featuring Molecules Against a Diverse Range of Biological Targets
19.3. Oral Protein / Peptide-based Therapeutics are being Designed to Treat a Wide Spectrum of Disease Indications; however, the Primary Focus is on Metabolic and Gastrointestinal Disorders
19.4. In Addition to Established Players, a Number of Start-ups, Backed by Venture Capital Investors, are Making Significant Contributions in this Domain
19.5. Several Stakeholders have Entered into Strategic Alliances Aimed at Promoting Research and Advancing Product Development Efforts
19.6. Post the Approval of Multiple Late-Phase Product Candidates, the Market is Anticipated to Grow Significantly in the Foreseen Future
19.7. Concluding Remarks

20. EXECUTIVE INSIGHTS
20.1. Chapter Overview
20.2. Anthera Pharmaceuticals
20.2.1. Company Snapshot
20.2.2. Interview Transcript: Dinesh Srinivasan, Director

20.3. Carmot Therapeutics
20.3.1. Company Snapshot
20.3.2. Interview Transcript: Stig K Hansen, CEO

20.4. IGY Life Sciences and Technology
20.4.1. Company Snapshot
20.4.2. Interview Transcript: Terry Dyck, President and CEO

20.5. Tarix Orphan
20.5.1. Company Snapshot
20.5.2. Interview Transcript: Richard Franklin, Director and CEO

21. APPENDIX 1: TABULATED DATA

22. APPENDIX 2: LIST OF COMPANIES

List of Figuers

Figure 3.1  Comparison of Key Characteristics of Biologics and Small Molecules
Figure 3.2  Classification of Proteins
Figure 3.3  Routes of Delivery for Proteins / Peptides
Figure 3.4  Drug Delivery: Distribution by Route of Administration
Figure 3.5  Mechanisms of Drug Transport through the Intestinal Epithelium
Figure 3.6  Mechanisms of Drug Transport through the Intestinal Epithelium via Attachment of Absorption Enhancers
Figure 3.7  Mechanisms of Drug Transport through the Intestinal Epithelium via Pro Drug Approach
Figure 3.8  Mechanisms of Drug Transport through the Intestinal Epithelium via Attachment of Enzyme Inhibitors
Figure 4.1  Oral Proteins / Peptides: Distribution by Phase of Development
Figure 4.2  Oral Proteins / Peptides: Distribution by Type of Molecule
Figure 4.3  Oral Proteins / Peptides: Distribution by Therapeutic Area
Figure 4.4  Oral Proteins / Peptides: Distribution by Key Biological Targets
Figure 4.5  Oral Proteins / Peptides: Distribution by Key Technology Platforms
Figure 4.6  Oral Proteins / Peptides: Distribution by Leading Players
Figure 5.1 Oral Proteins / Peptides Grid Analysis: Distribution by Therapeutic Area, Type of Molecule and Phase of Development
Figure 5.2  Oral Proteins / Peptides Developer Landscape: Distribution by Company Size and Phase of Development
Figure 5.3  Oral Proteins / Peptides Regional Landscape (Industry Players): Distribution by Company Location and Pipeline Strength
Figure 5.4 Oral Proteins / Peptides Recent / Upcoming Conferences: Distribution by Year and Geography
Figure 5.5  Oral Proteins / Peptides Recent / Upcoming Conferences: Regional Map
Figure 6.1  Linzess® and Trulance®: Mapping Prominent Researchers
Figure 6.2  Oral Proteins / Peptides: Prominent Key Opinion Leaders
Figure 7.1  Diabetes: Diagnostic Limits for Plasma Glucose Levels
Figure 7.2  Non-Insulin Therapies for Diabetes
Figure 8.1  Linzess®: Historical Sales, 2013-2017 (USD Million)
Figure 8.2  Trulance®: Historical Sales, Q1 2017-Q3 2017 (USD Million)
Figure 8.3  ALLN-177: Mechanism of Action
Figure 10.1  Axcess™ Oral Drug Delivery Technology: Components of Capsule
Figure 10.2  Peptelligence® Technology: Components of Enteric-Coated Tablet
Figure 10.3  Peptelligence® Technology: Drug Delivery Mechanism
Figure 11.1  Oral Drug Delivery Technology Platforms: Product Competitiveness Analysis
Figure 12.1  Oral Proteins / Peptides: Cumulative Number of Funding Instances, Pre-2008-2018
Figure 12.2  Oral Proteins / Peptides: Distribution of Amount Invested by Year, Pre-2008-2018 (USD Million)
Figure 12.3  Oral Proteins / Peptides: Distribution by Type of Funding, Pre-2008-2018
Figure 12.4  Oral Proteins / Peptides: Distribution of Total Amount Invested by Type of Funding, Pre-2008-2018 (USD Million)
Figure 12.5  Oral Proteins / Peptides: Most Active Players by Number of Funding Instances
Figure 12.6  Oral Proteins / Peptides: Most Active Investors by Number of Funding Instances
Figure 12.7  Oral Proteins / Peptides: Funding and Investment Summary
Figure 13.1  Oral Proteins / Peptides Partnerships: Cumulative Trend by Year (Pre-2008–2017)
Figure 13.2  Oral Proteins / Peptides Partnerships: Distribution by Type
Figure 13.3  Oral Proteins / Peptides Partnerships: Most Active Players
Figure 14.1  Publication Analysis: Cumulative Quarter-Wise Trend (Q1-Q4 2017)
Figure 14.2  Publication Analysis: Distribution by Type of Study
Figure 14.3  Publication Analysis: Distribution by Key Biological Targets
Figure 14.4  Publication Analysis: Distribution by Key Journals
Figure 15.1  Oral Proteins / Peptides: Trends on Twitter (2013-2017)
Figure 15.2  Oral Proteins / Peptides: Year-Wise Activity Analysis by Volume of Tweets (2013-2017)
Figure 15.3  Oral Proteins / Peptides: Popular Keywords on Twitter (2013-2017)
Figure 15.4  Oral Proteins / Peptides: Popular Therapeutic Areas on Twitter
Figure 15.5  Oral Proteins / Peptides: Popular Biological Targets on Twitter
Figure 15.6  Oral Proteins / Peptides: Popular Technology Platforms on Twitter
Figure 15.7  Oral Proteins / Peptides: Popular Drugs on Twitter
Figure 15.8  Oral Proteins / Peptides: Popular Players on Twitter
Figure 16.1  Overall Oral Proteins / Peptides Market, 2018-2030: Base Scenario (USD Billion)
Figure 16.2  Oral Proteins / Peptides Market: Market Attractiveness Analysis by Therapeutic Area, 2024 and 2030 (USD Billion)
Figure 16.3  Oral Proteins / Peptides Market: Distribution by Molecule Type, 2018, 2024 and 2030 (USD Billion)
Figure 16.4  Oral Proteins / Peptides Market: Distribution by Technology Platforms, 2018, 2024 and 2030 (USD Billion)
Figure 16.5  Oral Proteins / Peptides Market: Distribution by Geography, 2018, 2024 and 2030 (USD Billion)
Figure 16.6  Linzess® Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.7  Trulance® Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.8  TBRIA™ Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.9 ALLN-177 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.10 Mycapssa™ Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.11 NTRA-2112 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.12 Oral Semaglutide Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.13 Larazotide INN-202 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.14 NTRA-9620 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.15  AG013 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.16  IMM-124E Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.17  OPRX-106 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.18  KORSUVATM Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.19 Oral HDV Insulin Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.20 ORMD-0801 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.21  Oshadi Icp Oral Insulin Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.22 Ovarest® Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.23 SYN-004 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 16.24 V565 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 17.1  Key Steps Involved in the Manufacturing of Biologics
Figure 17.2  Approval Trend for Small Molecule and Large Molecule Drugs (2005-2017)
Figure 17.3  Factors for Selecting a CMO Partner
Figure 18.1  Oral Proteins / Peptides SWOT Analysis: Overview
Figure 18.2 Comparison of SWOT Factors: Harvey Ball Analysis
Figure 19.1  Oral Proteins / Peptides Market, Conservative, Base and Optimistic Scenarios, 2018, 2024 and 2030 (USD Billion)

List of Tables

Table 3.1  Compaison of Key Characteristics of Different Routes of Delivery
Table 4.1  Oral Proteins / Peptides: Development Pipeline
Table 4.2  List of Terminated / Withdrawn Oral Proteins / Peptides 
Table 5.1  Oral Proteins / Peptides: Recent / Future Conferences, 2014-2018
Table 6.1  Oral Proteins / Peptides: Principal Investigators
Table 7.1  Diabetes: Current Treatment Options
Table 7.2  Diabetes: Side Effects of Current Treatment Options
Table 7.3  Diabetes: Oral Proteins / Peptides Pipeline
Table 7.4  Obesity: Side Effects of Current Treatment Options
Table 7.5  Obesity: Oral Proteins / Peptides Pipeline
Table 7.6  NASH: Oral Proteins / Peptides Pipeline
Table 7.7  Ulcerative Colitis: Current Treatment Options
Table 7.8  Ulcerative Colitis: Side Effects of Current Treatment Options
Table 7.9  Ulcerative Colitis: Oral Proteins / Peptides Pipeline
Table 7.10  Crohn’s Disease: Current Treatment Options
Table 7.11  Crohn’s Disease: Side Effects of Current Treatment Options
Table 7.12  Crohn’s Disease: Oral Proteins / Peptides Pipeline
Table 7.13  CDIs: Diagnostic Testing
Table 7.14 CDIs: Severity Scoring System and Treatment Options
Table 7.15  CDIs: Side Effects of Current Treatment Options
Table 7.16  CDIs: Oral Proteins / Peptides Pipeline
Table 7.17  Celiac Disease: Oral Proteins / Peptides Pipeline
Table 7.18 Acromegaly: Current Treatment Options
Table 7.19  Acromegaly: Side Effects of Current Treatment Options
Table 7.20  Acromegaly: Oral Proteins / Peptides Pipeline
Table 7.21  Osteoporosis: Current Treatment Options
Table 7.22  Osteoporosis: Side Effects of Current Treatment Options
Table 7.23  Osteoporosis: Oral Proteins / Peptides Pipeline
Table 8.1  Oral Peptides / Proteins: List of Drugs Profiled
Table 8.2  Linzess®: Dosage Details
Table 8.3  Linzess®: Current Status of Development
Table 8.4  Linzess®: Clinical Trials
Table 8.5  Linzess®:  Results of Phase III Clinical Trial for CIC
Table 8.6  Ironwood Pharmaceuticals: Key Highlights
Table 8.7  Trulance®: Current Status of Development
Table 8.8  Trulance®: Clinical Trials
Table 8.9  Synergy Pharmaceuticals: Key Highlights
Table 8.10  TBRIA™: Current Status of Development
Table 8.11  TBRIA™: Clinical Trials
Table 8.12  TBRIA™: Results of Phase III ORACAL Clinical Trial 
Table 8.13  Tarsa Therapeutics: Key Highlights
Table 8.14  ALLN-177: Current Status of Development
Table 8.15  ALLN-177: Clinical Trials
Table 8.16  ALLN-177: Results of Phase II Clinical Trial for Enteric Hyperoxaluria
Table 8.17  Allena Pharmaceuticals: Key Highlights
Table 8.18  Mycapssa™: Current Status of Development
Table 8.19  Mycapssa™: Clinical Trials
Table 8.20  Mycapssa™: Results of Phase III Clinical Trial for Acromegaly
Table 8.21  Chiasma Pharma: Key Highlights
Table 8.22  NTRA-2112: Current Status of Development
Table 8.23  NTRA-2112: Clinical Trials
Table 8.24  Nutrinia: Key Highlights
Table 8.25  Oral Semaglutide: Current Status of Development
Table 8.26 Oral Semaglutide: Clinical Trials
Table 8.27  Novo Nordisk: Key Highlights
Table 9.1  Oral Proteins / Peptides: List of Other Associated Drugs
Table 9.2  Minirin®: Generic Versions
Table 9.3  Minirin®: Dosage Details
Table 9.4  Minirin®: Price of Tablets
Table 9.5  Minirin®: Patent Portfolio
Table 9.6  Minirin®: Competitive Landscape
Table 9.7  Sandimmune® / Neoral®: Generic Versions
Table 9.8  Sandimmune® / Neoral®: Dosage Details
Table 9.9  Neoral®: Patent Portfolio
Table 9.10  Sandimmune® / Neoral®: Competitive Landscape
Table 9.11  Sollpura®: Mechanism of Action
Table 9.12  Sollpura®: Current Status of Development
Table 9.13  Sollpura®: Clinical Trials
Table 9.14  Sollpura®: Current Treatment Options
Table 10.1  Oral Delivery Technology Platforms: Comparison of Key Features
Table 10.2  Oral Delivery Technology Platforms: Clinical Stages of Development
Table 10.3  Axcess™ Technology: Oral Proteins / Peptides Pipeline
Table 10.4  Eligen™ Technology: Oral Proteins / Peptides Pipeline
Table 10.5  Entera Technology: Oral Proteins / Peptides Pipeline
Table 10.6  NTRA Oral Delivery Technology: Oral Proteins / Peptides Pipeline 
Table 10.7  Peptelligence® Technology: Oral Proteins / Peptides Pipeline
Table 10.8  POD™ Technology: Oral Proteins / Peptides Pipeline
Table 10.9  TPE® Technology: Oral Proteins / Peptides Pipeline
Table 10.10  Uroguanylin Analogue Platform: Oral Proteins / Peptides Pipeline 
Table 12.1  Oral Proteins / Peptides: Funding and Investment Analysis
Table 12.2  Oral Proteins / Peptides: Summary of Investments
Table 13.1  Oral Proteins / Peptides: Recent Partnerships
Table 14.1  Oral Proteins / Peptides: List of Publications, 2017
Table 16.1  Oral Proteins / Peptides Market: Potential Candidates
Table 16.2 Oral Proteins / Peptides Forecast Assumptions: Price Estimation in Key Geographies
Table 16.3 Oral Proteins / Peptides Forecast Assumptions: Growth Rate Estimation by Key Indications
Table 16.4  Linzess®: Target Patient Population
Table 16.5  Trulance®: Target Patient Population
Table 16.6  TBRIA™: Target Patient Population
Table 16.7 ALLN-177: Target Patient Population
Table 16.8 Mycapssa™: Target Patient Population
Table 16.9  NTRA-2112: Target Patient Population 
Table 16.10  Oral Semaglutide: Target Patient Population
Table 16.11 Larazotide INN-202: Target Patient Population
Table 16.12 NTRA-9620: Target Patient Population
Table 16.13 AG013: Target Patient Population
Table 16.14  IMM-124E: Target Patient Population
Table 16.15 OPRX-106: Target Population
Table 16.16 Korsuva™: Target Patient Population
Table 16.17  Oral HDV Insulin: Target Patient Population
Table 16.18 ORMD-0801: Target Patient Population
Table 16.19 Oshadi Icp Oral Insulin: Target Patient Population
Table 16.20  Ovarest®: Target Patient Population
Table 16.21 SYN-004: Target Patient Population
Table 16.22 V565: Target Patient Population
Table 17.1  List of Contract Manufacturers Involved in Proteins / Peptides Manufacturing 
Table 20.1  Anthera Pharmaceuticals: Key Highlights
Table 20.2  Carmot Therapeutics: Key Highlights
Table 20.3  IGY Life Sciences and Technology: Key Highlights
Table 20.4  Tarix Orphan: Key Highlights
Table 21.1  Drug Delivery: Distribution by Route of Administration
Table 21.2  Oral Proteins / Peptides: Distribution by Phase of Development
Table 21.3  Oral Proteins / Peptides: Distribution by Type of Molecule
Table 21.4  Oral Proteins / Peptides: Distribution by Therapeutic Areas
Table 21.5  Oral Proteins / Peptides: Distribution by Key Biological Targets
Table 21.6  Oral Proteins / Peptides: Distribution by Key Technology Platforms
Table 21.7 Oral Proteins / Peptides: Distribution by Leading Players
Table 21.8  Oral Proteins / Peptides Recent / Upcoming Conferences: Distribution by Year and Geography
Table 21.9 Linzess®: Historical Sales, 2013-2017 (USD Million)
Table 21.10  Trulance®: Historical Sales, Q1 2017-Q3 2017 (USD Million)
Table 21.11  Oral Proteins / Peptides: Cumulative Number of Funding Instances, Pre-2008-2018
Table 21.12  Oral Proteins / Peptides: Distribution of Amount Invested by Year, Pre-2008-2018 (USD Million)
Table 21.13  Oral Proteins / Peptides: Distribution by Type of Funding, Pre-2008-2018
Table 21.14  Oral Proteins / Peptides: Distribution of Total Amount Invested by Type of Funding, Pre-2008-2018 (USD Million)
Table 21.15  Oral Proteins / Peptides: Most Active Players by Number of Funding Instances
Table 21.16  Oral Proteins / Peptides: Most Active Investors by Number of Funding   Instances
Table 21.17  Oral Proteins / Peptides Partnerships: Cumulative Trend by Year (Pre-2008–2017)
Table 21.18  Oral Proteins / Peptides Partnerships: Distribution by Type of Partnership
Table 21.19 Oral Proteins / Peptides Partnerships: Most Active Players
Table 21.20  Publication Analysis: Cumulative Quarter-Wise Trend (Q1-Q4 2017)
Table 21.21 Publication Analysis: Distribution by Type of Study
Table 21.22  Publication Analysis: Distribution by Key Biological Targets
Table 21.23  Publication Analysis: Distribution by Key Journals
Table 21.24  Oral Proteins / Peptides: Year-Wise Activity Analysis by Volume of Tweets (2013-2017)
Table 21.25  Overall Oral Proteins / Peptides Market, 2018-2030: Conservative, Base and Optimistic Forecast Scenarios (USD Billion)
Table 21.26  Oral Proteins / Peptides Market: Market Attractiveness Analysis by Therapeutic Area, 2024 and 2030 (USD Billion)
Table 21.27  Oral Proteins / Peptides Market: Distribution by Molecule Type, 2018, 2024 and 2030 (USD Billion)
Table 21.28  Oral Proteins / Peptides Market: Distribution by Technology Platforms, 2018, 2024 and 2030 (USD Billion)
Table 21.29  Oral Proteins / Peptides Market: Distribution by Geography, 2018, 2024 and 2030 (USD Billion)
Table 21.30  Linzess® Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.31  Trulance® Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.32 TBRIA™ Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.33 ALLN-177 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.34  Mycapssa™ Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.35  NTRA-2112 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.36 Oral Semaglutide Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.37 Larazotide INN-202 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.38  NTRA-9620 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.39  AG013 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.40  IMM-124E Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.41  OPRX-106 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.42  KorsuvaTM Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.43  Oral HDV Insulin Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.44  ORMD-0801 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.45  Oshadi Icp Oral Insulin Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.46  Ovarest® Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.47 PTG-100 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.48  SYN-004 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.49  V565 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 21.50  Approval Trend for Small Molecule and Large Molecule Drugs (2005-2017)
Table 21.51 Oral Proteins / Peptides Market, 2018, 2024 and 2030: Conservative, Base and Optimistic Scenarios (USD Billion)

Listed Compnaies

The following companies and organizations have been mentioned in the report:

  1. 3P Biopharmaceuticals
  2. 7-Med Health Ventures
  3. Aalto Scientific
  4. Abbott Laboratories
  5. AbbVie
  6. Abeona Therapeutics
  7. Abingworth
  8. ABL Venture Capital
  9. Abzena
  10. Access Pharmaceuticals
  11. ACES Pharma
  12. Acorn Biomedical
  13. ActoGeniX 
  14. Adage Capital Management
  15. Adams Capital Management
  16. Adams, Harkness & Hill Technology Ventures
  17. Adar Biotech
  18. Adcock Ingram
  19. Aegis Capital
  20. Aescap Venture
  21. Affilogic
  22. Affinity Life Sciences
  23. AIMM Therapeutics
  24. Ajinomoto Althea
  25. Alaven Pharmaceutical
  26. Alba Therapeutics
  27. Albireo Pharma
  28. Alcami
  29. Alchemia
  30. Aldevron
  31. Allena Pharmaceuticals
  32. Allergan
  33. Alliance Medical Products
  34. Almac
  35. Almirall
  36. Alnara Pharmaceuticals
  37. Alta Biopharma Partners
  38. Althea Technologies
  39. Altus Pharmaceuticals
  40. Alza Pharmaceuticals
  41. Amarillo Biosciences
  42. AmatsiQBiologicals
  43. AmbioPharm
  44. Amgen
  45. Anaheim Clinical Trials
  46. Anthera Pharmaceuticals
  47. Aphios
  48. Apotex
  49. Aptalis Pharma
  50. Aquestive Therapeutics
  51. Aravis Ventures
  52. ARCH Venture Partners
  53. Arena Pharmaceuticals
  54. ArisGen
  55. Arisaph Pharmaceuticals
  56. Armenian Development Agency
  57. Asahi Glass
  58. Ascent Biomedical Ventures
  59. Assaf Harofeh Medical Center
  60. Assembly Biosciences
  61. Astellas Pharma
  62. AstraZeneca
  63. Asymchem Laboratories
  64. Atara Technology Ventures
  65. Atrix Laboratories
  66. Augusta University
  67. AURA Biotechnologies
  68. AutekBio
  69. Avaxia Biologics
  70. Avid Bioservices
  71. Axcan Pharma
  72. AzurRx BioPharma
  73. Bachem
  74. Baekeland Funds
  75. Biomedical Advanced Research and Development Authority
  76. Barr Pharmaceuticals
  77. Batavia Biosciences
  78. Baxter BioPharma Solutions
  79. Bayer
  80. BCN Peptides
  81. Beacon Angels
  82. Beijing Friendship Hospital
  83. Beijing Tiantan Hospital
  84. Beijing Tongren Hospital
  85. Bessemer Venture Partners
  86. Beta Fund
  87. Bharat Serums and Vaccines
  88. BIBITEC
  89. Bill & Melinda Gates Foundation
  90. BIND Therapeutics
  91. BINEX
  92. Bio Elpida
  93. Biocell
  94. Biocon
  95. BioConnection
  96. Biodel
  97. Bio Farma
  98. Biogen
  99. Bio-Kinetic Clinical Applications
  100. Biolaxy
  101. Biolingus
  102. Biological Process Development Facility, University of Nebraska
  103. Biomatik
  104. Biomay
  105. BioPharmaceuticals Australia
  106. Biosynergy
  107. Bio-Synthesis
  108. Biotech Fund Flanders
  109. BioTechLogic
  110. Biotechnology and Biological Sciences Research Council
  111. Biotechpharma
  112. BioVectra
  113. BioVeda Capital
  114. Biovest
  115. Biovian
  116. Black Beret Life Sciences
  117. Boehringer Ingelheim Boehringer
  118. Bone Medical
  119. Bossa Nova Investmentos
  120. Boston Harbor Angels
  121. Botanix Pharmaceuticals
  122. Broadview Ventures
  123. Bumi Medic
  124. Buttonwood Financial
  125. BZ Bank
  126. Cadila Healthcare
  127. Calvert Research Institute
  128. Canaan Partners
  129. Canada Armenia Trading House
  130. Capsugel
  131. Cara Therapeutics
  132. CARBOGEN AMCIS
  133. Cardinal Health
  134. Carmot Therapeutics
  135. Catalent Pharma
  136. Cathay Venture
  137. Cedars-Sinai Medical Center
  138. Cell Culture Company
  139. Celltrion
  140. Celonic
  141. Center for Biocatalysis and Bioprocessing, University of Iowa
  142. Century Pharmaceuticals
  143. Cerbios-Pharma
  144. Changhai Hospital
  145. Changzheng Hospital
  146. Charles River Laboratories
  147. Chattem
  148. Chemi Peptides
  149. ChemPartner
  150. Cherrystone Angels
  151. Chiasma Pharma
  152. Chinese PLA General Hospital
  153. Chong Kun Dang Pharmaceutical
  154. Circle33
  155. ClinSearch
  156. CNF Investments
  157. Cobra Biologics
  158. Column Group
  159. Commercial & External Partnership, Industrial Affairs (CEPiA)
  160. Connecticut Innovations
  161. Constant Pharmaceuticals
  162. Cook Pharmica
  163. CordenPharma
  164. CoreMed
  165. Cosmo Pharmaceuticals
  166. Courtagen Life Sciences
  167. CPC Scientific Peptide Company
  168. CRG
  169. Crystal Horizon Investments
  170. CureDM
  171. Cystic Fibrosis Foundation Therapeutics
  172. CytoPharm
  173. Cytovance® Biologics
  174. D.N.A Biomedical Solutions
  175. Dalton Pharma Services
  176. Devon Park BioVentures
  177. Diabetology
  178. Diasome Pharmaceuticals
  179. Digestive Care
  180. DM Bio
  181. Docor International
  182. Duke University
  183. Edward P. Bass Group
  184. EirGenix
  185. Eli Lilly 
  186. Elite Research Institute
  187. European Medical Association
  188. Embio
  189. Emergent BioSolutions
  190. Emisphere Technologies
  191. Emory University
  192. Encap Drug Delivery
  193. Encorium Group
  194. enGene
  195. Engineered BioPharmaceuticals
  196. Engineering and Physical Sciences Research Council
  197. Entera Bio
  198. Enteris BioPharma
  199. Enterome Bioscience
  200. Entrega
  201. Esperante Ventures
  202. Eti Karle Clinical
  203. EuBiologics
  204. EUCODIS Bioscience
  205. Eurogentec
  206. European Commission
  207. European Cystic Fibrosis Society
  208. Evonik Industries
  209. F2 Capital
  210. F3 Ventures
  211. Ferrer Internacional
  212. Ferring Pharmaceuticals
  213. Fidelity Management & Research Company
  214. Firebird Global Master Fund
  215. First Affiliated Hospital of Harbin Medical University
  216. Forbion Capital Partners
  217. Foresite Capital
  218. Forest Laboratories
  219. Frazier Healthcare Partners
  220. FUJIFILM Diosynth Biotechnologies
  221. Gala Biotech
  222. GD Searle
  223. GE Healthcare
  224. General Hospital of Shenyang Military Region
  225. Generex Biotechnology
  226. GenIBET Biopharmaceuticals
  227. Genta
  228. GF Ventures
  229. GGV Capital
  230. Gila Therapeutics
  231. Gimv
  232. GlaxoSmithKline
  233. Glycotope Biotechnology
  234. Golden Seeds
  235. Goodwin Biotechnology
  236. Google Ventures
  237. GP-Pharm
  238. Grand River Aseptic Manufacturing
  239. Granite State Angels
  240. Great Point Partners
  241. GTP Technology
  242. H.I.G. BioHealth Partners
  243. Hadassah Medical Center
  244. HALIX
  245. Harvard Business School Angels
  246. Hayashibara Biochemical Laboratories
  247. HBM BioCapital
  248. HBM Partners
  249. Health Biotech
  250. Hefei Tianhui Incubator of Technologies
  251. Hemispherx Biopharma
  252. Hepasome Pharmaceuticals
  253. Heptares Therapeutics
  254. Hetero Drugs
  255. Hoechst Marion Roussel
  256. Hoffman La Roche
  257. Hong Kong Institute of Biotechnology
  258. Horizons Ventures
  259. Hovione
  260. iBio
  261. IDT Biologika
  262. IGY Life Sciences and Technology
  263. Immuron
  264. InCube Ventures
  265. Ingro Finanz
  266. Inno Biologics
  267. InnoMed Fund
  268. Innovate Biopharmaceuticals
  269. Institute for Promotion of Innovation by Science and Technology
  270. Intas Pharmaceuticals
  271. Integrity Bio
  272. Intrexon
  273. Ippon Capital
  274. Ipsen Pharma
  275. Ironwood Pharmaceuticals
  276. iSelect Fund
  277. Ivax Pharmaceuticals
  278. Janssen Biotech
  279. Jennison Associates
  280. JMP Securities Stifel
  281. Johnson & Johnson
  282. Jordanian Pharmaceutical Manufacturing
  283. Joslin Diabetes Center
  284. Julphar Gulf Pharmaceutical Industries
  285. Juvenile Diabetes Research Foundation (JDRF)
  286. Kamat PharmaTech
  287. KBI Biopharma
  288. Kemwell Biopharma
  289. KeyBioscience
  290. KPC Pharmaceuticals
  291. LAMPIRE Biological Laboratories
  292. LaunchPad Venture Group
  293. Layered Service Provider (LSP)
  294. LFB BIOMANUFACTURING
  295. Life Sciences Partners
  296. Lilly Ventures
  297. LODH Immunology Fund
  298. Longevity Biotech
  299. Lonza
  300. LuinaBio
  301. Lumira Capital
  302. Lundbeckfonden Ventures
  303. Lyfebulb
  304. Maine Angels
  305. Mallinckrodt Pharmaceuticals
  306. Marathon Capital Development Fund
  307. Maruishi Pharmaceutical Company
  308. Mass Medical Angels
  309. Massachusetts Institute of Technology
  310. Maverick Capital
  311. Maxim Group
  312. Mayo Clinic Foundation
  313. McDonald Partners
  314. Medeva Pharmaceuticals
  315. Medicxi Ventures
  316. MedImmune
  317. Medpace
  318. Menarini Biotech
  319. Mentor Pharmaceuticals
  320. Merck
  321. Meridian Life Science
  322. Merrion Pharmaceuticals
  323. Merro Pharmaceutical
  324. MHR Fund Management
  325. MicroBiopharm Japan
  326. MidaSol Therapeutics
  327. Midatech Pharma
  328. Millennium Pharmaceuticals
  329. Ministry of Industry, Trade and Labor of Israel
  330. Mitsubishi International
  331. Mitsubishi Tanabe Pharma
  332. Molecular and Cellular Therapeutics, University of Minnesota
  333. Monash University
  334. Montaur Capital Partners
  335. Morgan Stanley Investment Management
  336. MPM Capital
  337. MSD Partners
  338. MVM Life Science Partners
  339. Mylan
  340. NanoMega Medical
  341. National Institute of Allergy and Infectious Diseases
  342. National Institute of Diabetes and Digestive and Kidney Diseases
  343. National Institutes of Health
  344. National Institute of Neurological Disorders and Stroke
  345. National Multiple Sclerosis Society
  346. Neuland Laboratories
  347. New Generation Technology
  348. New River Management
  349. NewVa Capital Partners
  350. Niagara University
  351. Nitto Avecia Pharma Services
  352. Nobex
  353. NOD Pharmaceuticals
  354. Nordmark Arzneimittel
  355. Nordic Biosciences
  356. North Country Angels
  357. Northwest Pituitary Center, Oregon Health & Science University
  358. Nova Laboratories
  359. Novartis
  360. Novartis Venture Fund
  361. Novasep
  362. Novetide
  363. Novex
  364. Novimmune
  365. Novo Nordisk
  366. Nutrinia
  367. OctoPlus
  368. Ofer Hi-Tech Group
  369. Oklahoma Foundation for Digestive Research
  370. Olon
  371. Omnia Biologics
  372. Oragenics
  373. Oramed Pharmaceuticals
  374. Orange County Research Center
  375. OrbiMed
  376. Orexigen Therapeutics
  377. Oshadi Drug Administration
  378. OsoBio
  379. Oxford Finance
  380. P&G Pharmaceuticals
  381. Pacific Venture Opportunity Fund
  382. Panacea Biotec
  383. Paperboy Ventures
  384. Paragon Bioservices
  385. Partner Fund Management
  386. Patheon
  387. Peking University First Hospital
  388. Peking University Peoples Hospital
  389. Pendopharm
  390. Perceptive Advisors
  391. Pfizer
  392. Pfizer CentreOne
  393. Pharmacia & Upjohn
  394. Pharmstandard International
  395. Pictet Private Equity Investors
  396. Pinemount Investments
  397. Ping An Ventures
  398. Piramal Pharma Solutions
  399. Pituitary Center, Baylor St. Luke's Medical Center
  400. PlasmaTech Biopharmaceuticals
  401. PLIVA
  402. Polymun Scientific
  403. PolyPeptide Group
  404. Pontifax
  405. Praxis Pharmaceutical
  406. PREMAS Biotech
  407. ProBioGen
  408. Productos Biologicos
  409. ProJect Pharmaceutics
  410. ProMab Biotechnologies
  411. Prometheus Laboratories
  412. Protagonist Therapeutics
  413. Protalix Biotherapeutics
  414. Provantage® Biodevelopment Services (Merck Millipore)
  415. PureTech Health
  416. PvP Biologics
  417. PX'Therapeutics
  418. PYRAMID Laboratories
  419. QIC BioVentures
  420. Qilu Hospital of Shandong University
  421. QS Pharma
  422. Quaker BioVentures
  423. Queen's University
  424. RA Capital Management
  425. Rambam Health Care Campus
  426. Rani Therapeutics
  427. Rebel Pharmaceuticals
  428. Reliance Life Sciences
  429. Rentschler Biopharma
  430. Rho Ventures
  431. Richter-Helm BioLogics
  432. Ridgeback Capital
  433. Rock Springs Capital
  434. Rosetta Capital
  435. Ruijin Hospital
  436. Saffelberg Investments
  437. Sahlgrenska University Hospital
  438. Salix Pharmaceuticals
  439. Sandoz Pharmaceuticals
  440. Sanofi
  441. Sanyal Biotechnology
  442. Schering-Plough
  443. Scientific Health Development Partners
  444. Scientific Protein Laboratories
  445. SciGen
  446. Seachaid Pharmaceuticals
  447. Senn Chemicals
  448. Shanghai Zhongshan Hospital
  449. Sheba Hospital
  450. Shionogi
  451. Shire
  452. Sichuang Provincial People's Hospital
  453. Sigma Capital Management
  454. Sigmoid Pharma
  455. Slater Technology Fund
  456. Sofinnova Ventures
  457. Square 1 Bank
  458. SR One
  459. SRZ Properties
  460. Stallergenes
  461. Starfish Ventures
  462. Stealth BioTherapeutics
  463. Stevanato Group
  464. Sucampo Pharmaceuticals
  465. SV Health Investors
  466. Swiss Caps
  467. Symbiosis Pharmaceutical Services
  468. SynCo Bio Partners
  469. Synergy Pharmaceuticals
  470. Synermore Biologics
  471. Syngene
  472. Synthetic Biologics
  473. Syntex Pharm
  474. Takeda Pharmaceutical
  475. Takeda Ventures
  476. Tamares Capital
  477. Tamarix Technologies Group
  478. Tapemark
  479. Tarix Pharmaceuticals
  480. Tarsa Therapeutics
  481. Tech Coast Angels
  482. Temasek Holdings
  483. Teva Pharmaceutical
  484. Texas Tech University Health Sciences Center
  485. The Column Group
  486. The First Affiliated Hospital, Zhongshan University
  487. The Halifax Group
  488. The Native Antigen Company
  489. Thiel Foundation
  490. Third Affiliated Hospital of Guangzhou Medical University
  491. Therapure Biopharma 
  492. Thermo Fisher Scientific
  493. Third Rock Ventures
  494. Third Security
  495. Tiziana Life Sciences
  496. TNT Pharma
  497. TPG Biotech
  498. TPG Growth
  499. Transgene Biotek
  500. TranXenoGen
  501. Trenzyme
  502. TriHealth
  503. TVM Capital
  504. UCB Pharma
  505. Unigene Laboratories
  506. Union Hospital of Tongji Medical College of Huazhong University of Science & Technology
  507. United States Food and Drug Administration
  508. University of Washington
  509. University Hospital of South Manchester
  510. University of Alabama Fermentation Facility
  511. University of Alberta
  512. University of California
  513. University of Montreal
  514. University of Nebraska
  515. University of Southern California
  516. University of Texas
  517. University of Virginia
  518. University of Washington
  519. USV
  520. Vanderbilt-Ingram Cancer Center
  521. Varuma
  522. Venrock
  523. Ventria Bioscience
  524. VentureHealth
  525. Vertex Pharmaceuticals
  526. Vetter Pharma
  527. VHsquared
  528. Victory Park Capital
  529. Virginia Commonwealth University
  530. Virtus Inspire Ventures
  531. Vista Biologicals
  532. VIVUS
  533. vTv Therapeutics
  534. WACKER Biotech
  535. Waisman Biomanufacturing
  536. Watson Laboratories
  537. Wellington Management Company
  538. West China Hospital
  539. White Oak Global Advisors
  540. Wingate Institute of Neurogastroenterology
  541. WuXi AppTec
  542. WuXi Healthcare Ventures
  543. Wyeth Pharmaceuticals
  544. XBiotech
  545. Yissum
  546. Zealand Pharma
  547. Zosano Pharma
  548. Zhongshan Hospital
  549. Ziff Asset Managemen

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