Companies Providing Single Use Technology for Large Scale Bioprocessing

Published: December 2023


Given the various benefits of single use technology and the rising demand for biologics, the biopharmaceutical industry is gradually shifting from conventional stainless-steel technology to single use technology for large scale bioprocessing. We analyzed over 260 single use bioreactors equipped with various advanced key features, along with information on over 60 single use bioreactor manufacturers. In this article, discover top 9 bioreactor manufacturers using single use technology for large scale biologic manufacturing, that shine in the competitive landscape of Europe and Asia-Pacific.


Over time, biopharmaceuticals have garnered significant attention. The growth in the popularity can attributed to the fact that they offer favorable safety profiles, higher therapeutic efficacy, and ability to treat wide range of disease indications, that hard to treat. Given the success of these biologics, several players are prompted to upgrade the conventional manufacturing technology. One such example of upgrade includes introduction of single use technology. Over the past few years, single use technology market has increased at a steady pace. This can be attributed to the various benefits associated with single use technology such as reduction in consumption of water and energy (by ~45%), reduction in chances of cross-contamination (by 8%), removal in expenditure associated with cleaning and sterilization of equipment, increased cost saving potential and increase in productivity. Owing to the aforementioned advantages associated with single use technology and growing demand for effective biotherapeutics, several companies have emerged in this domain. These companies have developed and launched their proprietary single use upstream and single use downstream equipment. These include single use bioreactor, single use filtration system, single use sampling systems, single use chromatography system, single use sensors and single use connectors. In addition, stakeholders have also taken several initiatives to automate their existing single technology by introducing advanced features such as remote accessibility, visual data display, built-in system control sensors, data processing capability, ), provision for alarms / alerts and input / output compatibility and irradiation (gamma or x-ray). Despite the numerous advantages associated with single use technology, the adoption of this technology is fraught with some challenges, such as single use technology disposability, risk of extractables and leachable and sterilization / irradiation issues. However, the ongoing research, increasing adoption of single use technology and other technical advancements are anticipated to drive single use technology market and present a lucrative opportunity for bioprocessing equipment manufacturers in the foreseen future.

Roots Analysis has conducted an exhaustive study on Single Use Bioreactors Market featuring the current market landscape and future opportunity for the technology manufacturers involved in the manufacturing of technologies, over a span of 12 years.

Table of Contents

The top 9 single use technology companies manufacturing bioreactors are listed below (in alphabetical order):

  1. Applikon Biotechnology
  2. Cellexus
  3. CerCell
  4. CESCO Bioengineering
  5. Eppendorf
  6. PerfuseCell
  7. ProlifeCell
  8. Sartorius
  9. Solaris Biotechnology

Top 9 Single Use Technology

Interested in exploring all 60+ Single Use Bioreactor Manufacturers?

Discover Below the Details on Top 9 Single Use Technology Based Bioreactor Manufacturers

This article highlights top 9 leading bioreactors manufacturers using single use technology in Europe and Asia-Pacific to watch out for in 2023. The European companies presented in this article were established pre-2018 and offer more than five single-use bioreactors, whereas, the Asia-Pacific and Rest of the World  based companies offer maximum number of single-use bioreactors. It is essential to note that the selection of top players can differ substantially according to the defined criteria(s).

Applikon, a Netherland-based Single Use Technology Manufacturer Offering Various Stirred Tank and Wave Infused Bioreactors

Applikon Biotechnology - Single Use Technology

Applikon Biotechnology is a spin-off from a Vlaardingen-based glass technology company, and a global supplier of diverse line of bioreactor systems required for the production of antibodies, bioplastics, enzymes, and vaccines, in the biopharmaceutical and biotechnology domain.  Additionally, the firm has a strong portfolio of bioreactors that can be used for research and development purposes. The company claims to be a leading player in providing single-use reactors and control systems. Additionally, it offers reactors with the capability to scale up from laboratory to commercial scale. The company's product portfolio is complemented by an attractive recurring revenue model based on single-use reactors, service, and sensors. Further, it is worth highlighting that in January 2020, the company was acquired by Getinge.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
AppliFlex ST Stirred Tank Bioreactor
Hyperforma, 50 Stirred Tank Bioreactor
Hyperforma, 100 Stirred Tank Bioreactor
Hyperforma, 250 Stirred Tank Bioreactor
Hyperforma, 500 Stirred Tank Bioreactor
Hyperforma, 1000 Stirred Tank Bioreactorr
Hyperforma, 2000 Stirred Tank Bioreactor
AppliFlex RB 10L Wave Induced / Rocking Bioreactor
AppliFlex RB 25L Wave Induced / Rocking Bioreactor
AppliFlex RB 50L Wave Induced / Rocking Bioreactor
AppliFlex ST 500 mL Others
AppliFlex ST 3L Others
AppliFlex ST 15 L  Others

Recent Developments and Future Outlook

In March 2023, the company announced the launch of its 3D printed bioreactor (AppliFlex ST bioreactor) for lab-scale applications, which is available 500 mL, 3 L and 15 L capacity. Further, In September 2022, the company announced its participation in various events and conferences such as BioProcess International (held in Massachusetts, US) and Biotech Week Boston (held in Massachusetts, US). Despite the fact that publicly available information on company is fairly limited, we believe that the company is likely to continue focusing on such innovative products and presenting at international events in order to expand its area of expertise and offer a wide range of products to its clients.

Further information related to Applikon’s financial performance (if available), product portfolio and recent developments is available in the full report.
 

Cellexus Leveraging its Airlift Technology to Focus on Single Use Technology for Different Pharmaceutical Applications

Cellexus - Single Use Technology

Cellexus is a biotechnology company that develops and manufactures revolutionary single-use bioreactors using the airlift technology for applications in life sciences and pharmaceutical industries.  It offers a diverse range of products under its CellMaker brand of bioreactors. The company claims that its CellMaker bioreactors can accelerate the bioprocess and improve the cell culturing processes.  It is worth highlighting that the company’s offerings are available globally, through its distribution networks in Austria, Denmark, Israel, Norway, Spain, and Sweden.  Further, company states that its systems are equipped with 21 CFR PART 11 software that can be accessed via a touch screen. Moreover, it is worth highlighting that the company offers flexible rental options for their systems in addition to standard purchase models.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
Cellmaker Regular 8 L Pneumatically Mixed
Cellmaker Regular 50 L Pneumatically Mixed
Cellmaker Plus 8 L Pneumatically Mixed
Cellmaker Plus 50 L Pneumatically Mixed
Cellmaker Felix Pneumatically Mixed

Recent Developments and Future Outlook

In March 2022, the company entered into a product / technology integration agreement with Verder, in order to upgrade bioreactor systems leveraging latter company’s expertise. Further, in February 2022, the company entered into a product / technology development agreement with CB Technology, wherein the latter company was responsible for the development of a precision electronic controller unit for Cellexus’ CellMaker bioreactor. We anticipate the firm is expected to welcome more such partnership opportunities wherein it can expand its existing single-use bioreactors portfolio

Further information related to Celluxus’ financial performance (if available), product portfolio and recent developments is available in the full report.


CerCell is a Denmark-based Manufacturer Having Capability to Offer Innovative Single Use Technology for Antibodies and Vaccines

CerCel - Single Use Technology

CerCell, a subsidiary of Stobbe Pharma, is a biotechnology firm that designs and manufactures innovative single-use technologies for upstream manufacturing of antibodies and vaccines. The company also supplies customizable, unconventional, and visionary single-use solutions including contractors and process control systems to the pharmaceutical industry. Recently, the company added a highly customized CellMiscelatore Single-use-Mixers (SUMs) to their portfolio of offerings for the synthesis of mRNA, viral vectors and plasmids. The company claims that its single-use bioreactors are compatible with most of the existing process control systems, which makes it easier to replace with traditional glass / steel containers. These single-use bioreactors have fast turnaround time and are highly configurable with various available choices of components.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
CellVessel Config SUB 110 mm Stirred Tank Bioreactor
CellVessel Config SUB 130 mm Stirred Tank Bioreactor
CellVessel Config SUB 150 mm Stirred Tank Bioreactor
CellVessel Config SUB 200 mm Stirred Tank Bioreactor
CellVessel Config SUB 250 mm Stirred Tank Bioreactor
CellVessel Config SUB 400 mm Stirred Tank Bioreactor
CellVessel 0,5L Others
CellVessel 3,2L Others
CellVessel 5,7L Others
CellVessel 13L Others
CellVessel 30L Others

Recent Developments and Future Outlook

Recently, in May 2023, the company participated in the BioProcess International, held in Amsterdam, Netherlands. Despite the fact that publicly available information on the company is fairly limited, we believe that the company is likely to seek additional opportunities to participate in more of such conferences, in order to gain more visibility in the single-use bioreactors industry.
Further information related to CerCell’s financial performance (if available), product portfolio and recent developments is available in the full report.


CESCO Bioengeering, Manufacturer of TideCell Culture System, Continuously Innovating to Stay Ahead in Single Use Technology Market

CESCO - Single Use Technology

CESCO Bioengineering is a biotechnology company, focused on providing cell culture products and services, such as consumables, bioreactors, bioprocess instruments and platforms to biopharmaceutical industry. The firm claims to offer a wide range of lab, clinical and commercial scale bioreactors for biomanufacturing. It is worth mentioning that TideCell, is a single-use bioreactor of the company, designed for culturing different types of cells, and especially suited for production of vaccines and biologics.  Further, the TideCell system has the capability to control the duration of each feed and harvest cycle. In addition, these single-use bioreactors can adjust the temperature of process mass, pH / DO and CO2 concentration in the incubation chamber, gas flow, peristaltic pump speed, and valves for different gases.  Additionally, the firm offers customization options for product-process integration.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
TideCell 002 Pro HD Cell Culture System Fixed-Bed Bioreactor
TideCell-010 HD Cell Culture System Fixed-Bed Bioreactor
TideCell 020 HD Cell Culture System Fixed-Bed Bioreactor
TideCell 100 HD Cell Culture System Fixed-Bed Bioreactor

Recent Developments and Future Outlook

The company strives to have an elaborate quality management system from product design to commercialization, in order to meet customer expectations. As mentioned earlier, the company claims to have the required experience related to the manufacturing of various cell cultures. In fact, it offers its proprietary product range, TideCell single-use bioreactor systems, to clients. It is worth highlighting that, in December 2019, the TideCell HD cell culture system was evaluated for the production of high titer of rabies viral antigen.  In addition, the firm launched their PLC based TideCell-002 in the same month. Despite the fact that publicly available information is fairly limited, we believe that the company is likely to continue focusing on such innovative products in order to expand its area of expertise and offer a wider range of quality products to its client.
 

Eppendorf is Participating in Various Conferences to Lead the Market of Single Use Technology

Eppendorf - Single Use Technology

Eppendorf is a leading life science company that claims to develop and sell consumables and instruments. It also offers services for liquid, sample and cell culture handling in laboratories across the world. Further the company has an extensive portfolio of instruments, such as bioreactors, cell manipulation systems, centrifuges, CO2 incubators, DNA amplification equipment, dispensers, fermenters, mixers, spectrometers, shakers, ultra-low temperature freezers, pipettes and automated pipetting systems. The company has a customer base of different academic institutes, commercial research laboratories, and biotechnological, chemical, food, and pharmaceutical industries. It is worth mentioning that the firm has subsidiaries in 33 countries.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
BioBLU 0.3c Stirred Tank Bioreactor
BioBLU 0.3sc Stirred Tank Bioreactor
BioBLU 1c Stirred Tank Bioreactor
BioBLU 3c Stirred Tank Bioreactor
BioBLU 5c Stirred Tank Bioreactor
BioBLU 14c Stirred Tank Bioreactorr
BioBLU 10c Stirred Tank Bioreactor
BioBLU 50c Stirred Tank Bioreactor
BioBLU 0.3f Stirred Tank Bioreactorr
BioBLU 1f Stirred Tank Bioreactor
BioBLU 3f Stirred Tank Bioreactor
BioBLU 5p Stirred Tank Bioreactor
CelliGen BLU Bioreactor with Single-Use Vessels Stirred Tank Bioreactor
DASbox Cell Culture Single-Use Unspecified
DASbox Microbiology Single-Use Unspecified

Recent Developments and Future Outlook

In August 2022, the company participated in the ACHEMA 2022, held in Hesse, Germany. In June 2022, the company participated in the Analytica 2022, held in Bavaria, Germany. In order to gain more visibility, the company is anticipated to participate in more such events in the near future.

Further, in January 2021, the company announced the launch of BioFlo 720, a bioprocess control station for use with single-use bioreactors. Designed as a mobile controller, it can seamlessly scale-up with any biomanufacturing process, from R&D labs to pilot and commercial manufacturing facilities. We anticipate the company to launch additional technologies to build a comprehensive product portfolio.

Further information related to Eppendorf’s financial performance (if available), product portfolio and recent developments is available in the full report.
 

PerfuseCell is a Europe-based Manufacturer Developing Various Single Use Bioreactors for Protein Expression

PerfuseCell - Single Use Technology

PerfuseCell is a daughter company of Stobbe Pharma that offers next generation perfusion cultivating single-use bioreactors for the expression of proteins.  The firm focuses on the development, manufacturing, and supply of innovative, tailor-made single-use bioreactors to pharmaceutical industry for semi-steady-state cultivation of mammalian cell lines. It is worth highlighting that the company source ISO certified equipment from its sister company CerCell, PumpCell and Cronus-PCS.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
CellTernate Perfusion SUB Others
CellRetention-500 Others
CellRetention-3200 Others
CellMembra-500 Others
CellMembra-3200 Others
CellMembra-13000 Othersr

Recent Developments and Future Outlook

In 2023, the company participated in various conferences and events such as BioProcess International, (Amsterdam, Netherlands and California, US) and Cell & Gene Therapy, Manufacturing & Commercialisation congress in Dublin, Ireland. In the coming years, the firm is anticipated to continue participating in more of such events in order to gain more visibility in the single-use bioreactors industry.

Further information related to PerfuseCell financial performance (if available), product portfolio and recent developments is available in the full report.
 

ProlifeCell, Stobbe Pharma Company, Manufacturing Various Configurable Single Use Bioreactors for Mammalian Cells

ProlifeCell - Single Use Technology

ProlifeCell is a subsidiary of Stobbe Pharma that operates as its continuous cultivation / perfusion single-use bioreactors division.  The company claims to develop and manufacture a variety of configurable single-use bioreactors for cultivation of mammalian cells, for pharmaceutical applications. ProlifeCell mentions that owing to high cell density of its single-use bioreactors, conventional glass / steel reactors are being replaced by their scaffold-based single-use bioreactors.  Further, it is worth highlighting that ProlifeCell is a sister company of CerCell   which offers ISO certified manufacturing capabilities and resources to the former company for research and development, and continues manufacturing stem cells.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
CellCompact 32 Stirred Tank Bioreactor
CellCompact 33 Stirred Tank Bioreactor
CellTank 34 Stirred Tank Bioreactor
CellTank 35 Stirred Tank Bioreactor
CellReactor Others
CellDream Unspecified
iCORE Stirred Tank Bioreactor

Recent Developments and Future Outlook

In May 2023, the company participated in the BioProcess International, held in Amsterdam, Netherlands.  Further, in March 2023, the company participated in the BioProcess International, held in California, US. We expect the firm to participate in more of such events as it strives to build a reputation within single-use bioreactors market.

Further information related to ProlifeCell’s financial performance (if available), product portfolio and recent developments is available in the full report.
 

Sartorius has a Wide Range of Bioreactors based on Single Use Technology for Production of Recombinant Therapies

Sartorius - Single Use Technology

Sartorius Stedim Biotech, a subsidary of Sartorius, is a France based company having the required expertise in life sciences and healthcare domain. The company has a global footprint in more than 25 countries.  The company offers a wide range of exclusive single-use bioreactors specifically designed for developing cell and gene therapies, monoclonal antibodies, recombinant proteins, stem cells, and vaccines. Further, the company's portfolio of single-use bioreactors include models ranging from the 15 L-2,000 L of working volume, allowing simple scaling up and scaling down of the process. Additionally, the firm offers single-use bioreactors suitable for culturing different types of adherent cells and suspension cells.  As per company’s website its single-use products are highly performant, and well suited to meet current and future demands of its customers, ranging from process development to commercial scale manufacturing.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
Ambr 15 Cell Culture Stirred Tank Bioreactor
Ambr 250 High Throughput Perfusion Stirred Tank Bioreactor
Ambr 250 High Throughput Stirred Tank Bioreactor
Ambr® 250 Modular Stirred Tank Bioreactor
BIOSTAT RM 20 Wave Induced / Rocking Bioreactor
BIOSTAT RM 50 Wave Induced / Rocking Bioreactor
BIOSTAT RM 200 Wave Induced / Rocking Bioreactor
BIOSTAT RM 600 Wave Induced / Rocking Bioreactor
BIOSTAT STR 50L Stirred Tank Bioreactor
BIOSTAT STR 200L Stirred Tank Bioreactor
BIOSTAT STR 500L Stirred Tank Bioreactor
BIOSTAT STR 1000L Stirred Tank Bioreactor
BIOSTAT STR 2000L Stirred Tank Bioreactor
UniVessel SU Stirred Tank Bioreactor

Recent Developments and Future Outlook

In January 2023, Sartorius entered into a product / technology integration agreement with RoosterBio, in order to advance upstream processes for the production of exosomes, using its proprietary single-use bioreactors.  Further, in October 2022, the company entered into a research and development agreement with BASE in order to support process development and pre-clinical development of nucleic acids products, by leveraging its proprietary single-use bioreactors. 

The firm is expected to continue undergo various collaborations with other leading players, in order to address challenges related to biomanufacturing by delivering innovative single-use bioreactors to the pharmaceutical industry.

Further information related to Sartorius’ financial performance (if available), product portfolio and recent developments is available in the full report.
 

Solaris Biotechnology, a Key Player in the Field of Stirred Type Single Use Bioreactor

Solaris Biotechnology - Single Use Technology

Solaris Biotechnology is a company that offers specialized bioreactors and fermenters for research, development and commercial purposes. Notably, in November 2021, the company was acquired by Donaldson for an amount of nearly EUR 41 million in order to strengthen its product portfolio.  Currently, the company is operating through two business units, namely Solaris Lab and Solaris Industrial. Solaris Lab is dedicated to the production of lab equipment ranging from 120 ml up to 20 L, whereas Solaris Industrial focuses on the customizable cGMP pilot to commercial scale equipment (up to 30,000 L). The company claims to serve the agricultural, food and beverage, chemical, cosmeceutical, and pharmaceutical sectors, which are supported by 30 distributors worldwide. Further, the company claims to have integrated its single-use bioreactor portfolio with a comprehensive measurement and control options, such as antifoam, cell density (total cells, viable cells), conductivity, dO2, dCO2, pH, redox, temperature, and weight. In addition, the bioreactors enable advanced display / control features such as touch screens.  It is worth mentioning that the company offers a wide range of single-use bioreactor that can be used for various applications in basic research, process development and optimization, scale up and scale-down studies, and production.

Single Use Technology: List of Bioreactors

Product Name Type of Bioreactor
Jupiter 2.0 Stirred Tank Bioreactor
Jupiter 4.0 Stirred Tank Bioreactor
Jupiter 6.5 Stirred Tank Bioreactor
Jupiter 8.0 Stirred Tank Bioreactor
Jupiter 10.0 Stirred Tank Bioreactor
Genesis 7.5 Stirred Tank Bioreactor
Genesis 10.0 Stirred Tank Bioreactor
Genesis 15.0 Stirred Tank Bioreactor
Genesis 19.9 Stirred Tank Bioreactor
M series 30 Stirred Tank Bioreactor
M series 50 Stirred Tank Bioreactor
M series 75 Stirred Tank Bioreactor
M series 100 Stirred Tank Bioreactor
M series 150 Stirred Tank Bioreactor
M series 200 Stirred Tank Bioreactor

Recent Developments and Future Outlook

Over the past few months, Solaris Biotech participated in various conferences such as Labvolution, held in Hannover, Germany and Annual Meat Evolution Leaders Summit 2023, held in Berlin, Germany. We anticipate the firm is expected to continue to showcase its innovative solutions at upcoming conferences.

Further information related to Solaris Biotech’s financial performance (if available), product portfolio and recent developments is available in the full report.

What About the Other Single Use Bioreactor Manufacturers?

The above presentation features 10 promising companies using single use technology for large scale bioprocessing. If you're interested, you can download the Sample Report on this topic by Roots Analysis. For personalized assistance in identifying the most relevant solutions based on your specific criteria, please don't hesitate to reach out to us at sales@rootsanalysis.com.

About Author

Ankita_Kashyap

Ankita_Kashyap is a business research and competitive intelligence professional with over four years of experience in the pharmaceutical and healthcare industry. As an associate at Roots Analysis, she has authored numerous trending multidisciplinary market research reports, including viral vectors, aseptic manufacturing, continuous manufacturing, bioprinting, ADC technology, membrane filtration, liquid biopsy and more. She has continuously provided her valuable insights into the latest innovations in healthcare. During her professional journey, she has acquired good analytical skills in the pharmaceutical and biopharmaceutical industry, which in turn has contributed to the firm’s intellectual capital. This has allowed our clients to make informed decisions in the dynamic pharmaceutical landscape. She embarked upon her career with us. She started her journey as a business analyst with Roots Analyst and in such a short span of time, she has demonstrated amazing dedication. Till date, she has contributed to over 20 research reports.

Ankita holds a Master’s degree in Pharmacology from Chitkara University. While pursuing her education, she contributed her skills for various review and research literature. The impact of her learnings can be found   in her professional blogs, market research reports and social media profiles.

Source1: https://www.labonline.com.au/content/lab-equipment/hot-product/appliflex-st-bioreactor-for-single-use-customisable-bioprocessing-1446586764
Source2: https://cellexus.com/blog/press-cellexus-partner-with-scottish-company-cb-technology/
Source3: https://corporate.eppendorf.com/en/press-releases/14012021-streamlining-process-scale-up-with-the-new-eppendorf-bioflor-720-bioprocess-controller/

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