Small Scale Bioreactors Market Key Players

Published: September 2025

Small scale bioreactors, also known as miniature, mini or micro bioreactors, which enable scale down bioprocessing for various cell cultures (mammalian, viral, fungal, bacterial, and insect cell culture). The miniature bioreactor systems have same flexibility as laboratory scale bioreactors and can be customized to fit the requirements of any process. The small volume of media used in the system helps reduce the cost and enables applications, such as screening studies, media optimization, process optimization, microbial & cell culture, batch, fed-batch, perfusion and continuous cultivation.

The miniaturization of cultivation equipment is an important step towards the rapid development of bioprocesses and robust cell factories. There are several types of small-scale bioreactors and prospective sensor systems for convenient online monitoring, as well as automated bioprocesses and fed batch cultivation. These bioreactors help in bridging the gap between small-scale cultivation and large-scale fermentation, thereby enabling faster process development and reduction in the process cost.

Roots Analysis has conducted an exhaustive study on Small Scale Bioreactors Market featuring the current market landscape and future opportunity for the companies engaged in providing small scale bioreactors, ranging from 20 mL-200 L, over a span of next 10 years.

Small Scale Bioreactors Market Key Players

Danaher
Eppendorf
Merck Millipore
Sartorius
Thermo Fisher Scientific

The figure below highlights the small scale bioreactors market key players:

Small Scale Bioreactors Market Leading Players

Interested in exploring more than 95 players providing over 370 small scale bioreactors, ranging from 20 mL-20 L and their recent initiatives?

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Discover Below the Details on Small Scale Bioreactors Market Key Players

Discover Below the Details on Small Scale Bioreactors Market Key Players
Let us dive deep into the details of the small scale bioreactors market key players. It is essential to note that the selection of top players can differ substantially according to the defined criteria.

1. Danaher

Company Overview

Danaher offers small scale bioreactors with its two subsidiaries, Pall Corporation and Cytiva. Pall Corporation claims to be an innovative technology and solution provider that broadly operates through two units, namely Pall Life Sciences and Pall Industrial. Pall Life Sciences is a biotechnology firm, that claims to offer high-tech filtration, separation and purification processes. The company is focused on developing engineered vaccines and biotechnology drugs. It caters to the needs of the beverage, food, biotechnology, medical and pharmaceutical industries through its operations in 80 locations, across the globe.

Cytiva is a life sciences firm, focused on the research and development of innovative vaccines, biologic drugs, novel cells and gene therapy. It provides technologies and services to other companies engaged in the development and manufacturing of therapeutics.

List of Small Scale Bioreactors along with their Total Volume

S. No.	Product Name	Total Volume
1	Allegro STR	50 L, 200 L
2	Allegro XRS Bioreactor 25	25 L
3	iCELLis™ 500+ System	70 L
4	iCELLis™ Nano System	1 L
5	PadReactor® System	25 L, 5 L, 125 L
6	Pall 3.2 liter standard SUB	3.2 L
7	WAVE Bioreactor™ System	10 – 100 L
8	Xcellerex™ XDR	10 L, 50 L, 200 L
9	Xcellerex™ X-platform Bioreactors	50 L, 200 L
10	Xuri™ Cellbag™ bioreactor	2 L, 10 L, 20 L, 50 L

Recent Developments

In March 2025, Cytiva expanded its Xcellerex X-platform portfolio by adding 500 L and 2000 L bioreactors. These new sizes enable scientists and researchers to more easily scale up manufacturing of next-generation advanced therapeutics.

To know more about the recent initiatives of Danaher and other small scale bioreactors market key players, access full report.

2. Eppendorf

Company Overview

Eppendorf is a life sciences firm, focused on the development and commercialization of consumables and instruments. It offers services for liquid sampling and cell culture handling in laboratories, worldwide. The company has a vast product portfolio, consisting of bioreactors, cell manipulation systems, centrifuges, CO2 incubators, DNA amplification equipment, dispensers, fermenters, mixers, pipettes and automated pipetting systems, spectrometers, shakers, and ultra-low temperature freezers. According to the firm, it has subsidiaries across 28 countries and serves stakeholders in various academic institutes, commercial research laboratories, biotechnological, chemical, food and pharmaceutical industries.

List of Small Scale Bioreactors along with their Total Volume

S. No.	Product Name	Total Volume
1	BioBLU f Single-Use Bioreactors (0.3f, 1f, 3f)	380 mL, 1.8 L, 5 L
2	BioBLU® c Single-Use Bioreactors (0.3c, 0.3sc, 1c, 3c, 10c, 50c, 5p)	380 mL, 380 mL, 1.8 L, 5 L, 13.3 L, 50 L, 5 L
3	BioFlo® 120 / 320 Bioreactors	1.3 L, 3 L, 7.5 L, 14 L
4	BioFlo® 510 / CelliGen 510	40 L
5	DASbox® Mini Bioreactor	350 mL
6	DASGIP® Bioblock/SciVario® twin Spinner Vessels	1.5 L, 1.9 L, 2.3 L
7	DASGIP® Bioblock/SciVario® twin Stirrer Vessels	1.3 L, 1.8 L, 2 L, 2.1 L
8	SciVario® twin Benchtop Bioreactors for Cell Culture	3.1 L, 4.3 L
9	SciVario® twin Benchtop Bioreactors for Microbiology	3.1 L, 4.3 L

Recent Developments

In June 2024, Eppendorf partnered with NSG BioLabs to provide biotech startups the access to cutting-edge equipment, consumables, services, and expertise within NSG BioLabs’ co-working lab and office spaces to accelerate their research and development.

To know more about the recent initiatives of Eppendorf and other small scale bioreactors market key players, access full report.

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3. Merck Millipore

Company Overview

Merck Millipore is a life sciences division of Merck, supports the research, development, and manufacturing needs of the biotechnology and pharmaceutical industries. The company operates through bioscience, lab solutions, and process solutions units. Within the bioprocessing domain, Merck Millipore specializes in providing scalable and controlled environments through small scale bioreactors. These systems are crucial for process development, optimization, and scale-up of cell culture and fermentation processes, enabling consistent cell growth and sterile conditions. Their applications span biopharmaceutical research, early-stage production, and pilot-scale manufacturing, driving innovations in vaccines, advanced therapeutics, and biologics.

List of Small Scale Bioreactors along with their Total Volume

S. No.	Product Name	Total Volume
1	Mobius® iFlex Bioreactors	200 L
2	Mobius® Single-use Bioreactors	3 L, 60 L

Recent Developments

In May 2024, Merck Millipore acquired Mirus Bio in $ 600 Million to enhance its capabilities in viral vector manufacturing for cell and gene therapies.

To know more about the recent initiatives of Merck Millipore and other small scale bioreactors market key players, access full report.

4. Sartorius

Company Overview

Sartorius is a biopharmaceutical company providing bioprocess solutions to stakeholders in life science research and the biopharmaceutical industry. The company emphasizes integrating advanced automation and analytics to streamline workflows and enhance process reliability across research and manufacturing stages. Further, in the small scale bioreactors domain, Sartorius focuses on providing flexible, scalable, and single-use systems that support process development, optimization, and scale-up for cell culture and fermentation. Their solutions enable efficient and cost-effective biopharmaceutical production, facilitating innovations in biologics, vaccines, and advanced therapies.

List of Small Scale Bioreactors along with their Total Volume

S. No.	Product Name	Total Volume
1	Ambr® 250 Modular	350 mL
2	Ambr® 250 High Throughput / Ambr® 250 High Throughput Perfusion	250 mL
3	Biostat STR® Generation 3	50 L, 200 L
4	Biostat® B	1 L, 2 L, 5 L, 10 L
5	Biostat® B-DCU	2 L, 5 L
6	Biostat® RM Bioreactor	20 L, 200 L
7	UniVessel SU	2 L

Recent Developments

In August 2023, Sartorius partnered with Repligen to launch an integrated bioreactor system that incorporates Repligen’s XCell® ATF upstream intensification technology into Sartorius’ Biostat STR® bioreactor. The primary goal of this integrated system is to simplify the implementation of intensified seed train and perfusion (N perfusion) for biopharmaceutical manufacturers, enhancing process efficiency and control.

To know more about the recent initiatives of Sartorius and other small scale bioreactors market key players, access full report.

5. Thermo Fisher Scientific

Company Overview

Thermo Fisher Scientific is a global leader in laboratory and bioprocessing solutions, and it offers an extensive portfolio of small scale bioreactors tailored for research, process development, and scale-up needs. Notably, these bioreactors emphasize consistent design and advanced automation software, which ensures smooth process transfer as well as robust data integration across all scales. In addition, the systems feature user-friendly, single-use formats and sustainable biobased film options.

List of Small Scale Bioreactors along with their Total Volume

S. No.	Product Name	Total Volume
1	DynaDrive S.U.B.	5 - 200 L
2	HyPerforma™ Glass Bioreactor	1 L, 3 L, 7 L, 15 L
3	HyPerforma™ Rocker Bioreactor	10 L, 20 L, 50 L
4	HyPerforma™ Single-Use Bioreactor (S.U.B.)	50 L, 100 L

Recent Developments

In April 2025, Thermo Fisher Scientific introduced the 5 L DynaDrive single use bioreactor, a compact system to meet the diverse needs of large biopharma, CDMOs, and small biotech companies.

To know more about the recent initiatives of Thermo Fisher Scientific and other small scale bioreactors market key players, access full report.

What About Other Small Scale Bioreactor Companies Around the World?

The above article features the small scale bioreactors market key players selected from a pool of more than 95 players, providing over 370 small scale bioreactors, ranging from 20 mL-200 L, that we have compiled. If you're interested, you can download the Sample Report on this topic by Roots Analysis. For personalized assistance in identifying the most relevant solutions based on your specific criteria, please don't hesitate to reach out to us at sales@rootsanalysis.com.

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