Top 5 Digital Biomanufacturing Companies

Published: November 2025

Digital biomanufacturing refers to an end-to-end process of manufacturing biologics, which integrates the usage of digital technologies for enhancing the overall manufacturing efficiency and product quality. This process primarily involves the use of various digital technologies / software, such as process analytical technology (PAT), manufacturing execution systems (MES), digital twin (DT) and data analytical software (DAS).

In recent years, the biopharmaceutical manufacturing industry has witnessed an increase in the adoption of digital manufacturing technologies. In fact, according to research, around 20% of the biopharma companies have already adopted digital approaches for manufacturing biologics. This can be attributed to the various advantages of digitalization in manufacturing operations. These include reduced development timeline, reduced cost of manufacturing, reduced product variability and increased product quality. The various advantages of such approaches, coupled with their ability to ensure an uninterrupted supply chain of good quality drugs, is expected to drive the growth of this market.

It is worth highlighting that although digitalization has its set of benefits, it is associated with certain limitations as well. These include challenges related to complexity, quality and security of the data generated across these systems, requiring specialized management expertise. Nevertheless, the opportunities presented by such approaches are expected to revolutionize the current manufacturing landscape, presenting lucrative growth prospects in the coming years.

Roots Analysis has conducted an exhaustive study on Digital Biomanufacturing Market featuring the current market landscape and future opportunity for the digital biomanufacturing technologies / systems over a span of 10 years.

Top Five Promising Digital Biomanufacturing Companies

The figure below highlights the top five digital biomanufacturing companies:

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Discover Below the Details on Top 5 Digital Biomanufacturing Companies

Let us dive deep into the details of the top 5 digital biomanufacturing companies. These companies were chosen based on the number of digital technologies / software offered (at least two) and their year of establishment (companies established before 1947). Interestingly, all the companies shortlisted are based in Germany, Europe, depicting high market concentration and competition in this region. It is essential to note that the selection of top players can differ substantially according to the defined criteria.

Eppendorf is Actively Engaged in Offering a Portfolio of Digital manufacturing technologies / software

1. Eppendorf

Eppendorf is a life science company that is engaged in the development and commercialization of instruments, consumables, and services for handling liquid, samples, and cells across the globe. The firm offers a variety of products, including automated pipetting systems, dispensers, centrifuges, spectrometers, ultra-low temperature freezers, bioreactors and shakers to academic research laboratories, pharmaceutical companies and biotechnology industries. Additionally, the company provides bioprocess software solutions to their customers to support them in planning, executing, monitoring, controlling and analyzing the entire bioprocess workflow. Further, the firm claims to offer comprehensive upstream bioprocessing solutions to facilitate enhanced bioprocess automation and controlled cell cultivation.

Eppendorf offers multiple digital biomanufacturing technologies / software, including DAS and PAT.

Technology / Software Portfolio

The company provides technology / software with different capabilities that allow its clients to enhance their ability to monitor, control, and log data from bioprocesses digitally. The capabilities of various technologies / software offered by Eppendorf include:

Data Analytics Software Name	Details
BioNsight cloud	Deployment Option: Cloud-based Software Capabilities: Process Intelligence, Data Integration, Real-time Process Monitoring, Data Visualization, Performance Analysis and Control Prediction Integrated Technology: Artificial Intelligence / Machine Learning
BioCommand SCADA Software	Deployment Option: Unspecified Software Capabilities: Process Intelligence, Data Integration, Real-time Process Monitoring, Data Visualization, Performance Analysis and Control Prediction Regulatory Compliance: FDA
Process Analytical Technology Name	Details
DASware®	Deployment Option: Unspecified Technology Capabilities: Process Automation, Bioprocess Optimization and Controls, Process Monitoring and Visualization, Performance Analysis, and Report Generation and Documentation. End Users: Industry and Non-Industry

Recent Developments

In June 2025, the company presented BioNsight, its cloud-based monitoring and analytics software for bioprocess equipment, at BioProcess International Europe (BPI Europe).
In December 2024, the company entered into a technology integration agreement with DataHow to integrate BioNsight cloud with DataHowLab solution in order to drive advance bioprocess data management.

To know more about Eppendorf and other digital biomanufacturing companies, access our full report.

Körber, a Strategic Management holding company, is Focused on Shaping Technological change with Innovative, Customer-specific Product solutions

2. Körber

Körber is a Germany based company, that is engaged in providing digital twin technologies and manufacturing execution systems to various industries, including automation, logistics and pharmaceuticals. The company claims to deliver extensive and reliable software portfolio for end-to-end automation of the manufacturing operations. Further, the company claims that clients can leverage various solutions, including seamless data aggregation, user-friendly process monitoring and insightful analysis for the full spectrum of biomanufacturing, using its proprietary technologies.

Körber offers multiple digital biomanufacturing technologies / software, including DT, DAS and MES.

Technology / Software Portfolio

The company provides technology / software with different capabilities that allow its clients to achieve end-to-end automation of their manufacturing operations. The capabilities of various technologies / software offered by Körber include:

Digital Twin Name	Details
PAS-X Savvy IPM	Technology Capabilities: Process Modeling / Designing, Process Validation, Process Optimization, Quality Control, Real-time Monitoring Type of Twins: Process Twin
Data Analytics Software Name	Details
Werum PAS-X Savvy	Deployment Option: Web-based Technology Capabilities: Process Intelligence, Data Integration, Real-time Process Monitoring, Data Visualization, Performance Analysis and Control Prediction, and Reporting and Data Management End Users: Industry
Manufacturing Execution System Name	Details
Werum PAS-X MES Suite	Deployment Option: On-premise and Cloud-based Integrated Software: Enterprise Resource Planning (ERP), Product Lifecycle Management (PLM) Technology Capabilities: Document Control, Production Tracking, Performance Analysis and Data Integration Regulatory Compliance: FDA, GMP, EU, ISO, ISA

Recent Developments

In May 2025, the company announced the launch of its new software solutions at Körber Software Pharma Open. The event was primarily focused on presenting the latest advancements in the company’s PAS-X software solutions, along with new launches (including PAS-X MES 3.4, PAS-X K.AI, PAS-X data access, manufacturing dashboards and digital twins, PAS-X track & trace and PAS-X services).
In March 2025, the company granted the PAS-X MSI Plug & Produce certification to HighByte Intelligence Hub for accelerating the digital transformation of manufacturing in the life science industry. This integration is aimed to eliminate the need for complex custom coding, reduce deployment timeline and ensure seamless data exchange for advanced analytics and regulatory compliance.

To know more about Körber and other digital biomanufacturing companies, access our full report.

Merck Offers Adaptive Platforms for Achieving Intensified, digitally connected, Continuous Bioprocessing

3. Merck

Merck is a Germany based biopharmaceutical company, which operates profoundly in the healthcare, life science and electronics domain worldwide. The company claims to offer a broad range of therapeutic products, personalized treatment options for serious ailments, technologies and services in the fields of research, diagnostics and pharma sectors. Further, the firm claims to provide extensive expertise in next-generation manufacturing to promote continuous bioprocessing. It is worth highlighting that the company provides a plethora of flexible and agile data visualization, analytics, and process monitoring technologies to its clients in order to improve biologics development and to accomplish bioprocessing goals.

Merck offers multiple digital biomanufacturing technologies / software, including PAT and DAS.

Technology / Software Portfolio

The company provides technology / software with different capabilities that allow the advancement and digitalization of bioprocess with increased speed, enhanced flexibility and quality. The capabilities of various technologies / software offered by Merck include:

Process Analytical Technology Name	Details
BioContinuum	Deployment Option: Unspecified Technology Capabilities: Process Automation, Bioprocess Optimization and Controls, Process Connectivity, Data Integration, Process Monitoring and Visualization Type of Biologics Manufactured: Antibodies, Biosimilars Regulatory Compliance: FDA
Bio4C PAT Raman	Deployment Option: Unspecified Technology Capabilities: Process Automation, Bioprocess Optimization, Data Integration, Process Monitoring and Visualization, Performance Analysis Additional Capabilities: Quality by design (QbD) Approach Regulatory Compliance: FDA
Data Analytics Software Name	Details
Bio4C ProcessPad	Deployment Option: Unspecified Technology Capabilities: Process Intelligence, Data Integration, Data Visualization, Performance Analysis and Control Prediction, and Reporting and Data Management Regulatory Compliance: FDA End Users: Industry and Non-Industry

Recent Developments

In March 2025, the company shared its vision for SMARTfacturing Ecosystem, representing an integration of advanced digital technologies, for addressing the current challenges related to biomanufacturing and preparing for future disruptions. The company claimed to envision a future of modular, reconfigurable factories capable of dynamically adjusting production processes, product designs, and logistics in response to shifting demands.
In January 2025, the company announced the launch of its digital twin platform M-Trust, enabling manufacturers to digitalize their quality control processes and streamline their biomanufacturing operations.

To know more about Merck and other digital biomanufacturing companies, access our full report.

Sartorius Offers AI predictive tools, Digital solutions and Equipment for the biopharmaceutical manufacturing industry

4. Sartorius

Sartorius is a Germany based company engaged in offering various products and services to life sciences and healthcare industry. The company’s business operations span across two divisions, namely bioprocess solutions, and lab products and services. Further, it states to provide the aforementioned solutions through its two subsidiaries, namely Sartorius Lab and Sartorius Stedim Biotech. It is worth mentioning that the company has a global footprint in more than 60 countries. As per the firm’s website, it offers a wide range of innovative software suites to various biopharmaceutical industries in order to streamline its early-stage development processes. Further, the company has developed substantial competence over the last few years in standardizing automation and optimizing biomanufacturing processes for its customers.

Sartorius offers multiple digital biomanufacturing technologies / software, including PAT and DAS.

Technology / Software Portfolio

The company offers an extensive range of software with various capabilities that enable its clients to implement data management and automation in the biomanufacturing operations. According to the company, its technologies provide reliable data gathering, real-time monitoring, effective visualization, insightful analysis and advanced process control for all upstream and downstream processes. The capabilities of various technologies / software offered by Sartorius include:

Process Analytical Technology Name	Details
BioPAT® DCU	Deployment Option: Unspecified Technology Capabilities: Process Automation, Bioprocess Optimization and Controls, Scalability, Process Monitoring and Visualization Type of Biologics Manufactured: NA Regulatory Compliance: NA
BioPAT® MFCS	Deployment Option: On-premise Technology Capabilities: Process Automation, Process Connectivity, Scalability, Data Integration, Process Monitoring and Visualization, Report Generation and Documentation Regulatory Compliance: FDA, EU, GMP

Data Analytics Software Name	Details
SIMCA	Deployment Option: On-premises Software Capabilities: Process Intelligence, Data Integration, Data Visualization, Performance Analysis and Control Prediction, Reporting and Data Management Regulatory Compliance: FDA Integrated Technology: Big Data
SIMCA-online	Deployment Option: On-premises, Web-based Software Capabilities: Process Intelligence, Real-time Process Monitoring, Data Visualization, Performance Analysis and Control Prediction Regulatory Compliance: FDA
MODDE	Deployment Option: On-premises Software Capabilities: Process Intelligence, Data Visualization, Performance Analysis and Control Prediction, Reporting and Data Management Additional Capabilities: Quality by design (QbD) Approach Regulatory Compliance: FDA, ISO 9001

Recent Developments

In June 2025, the company launched an industry event focused on process intensification (PI) for emerging modalities and protein therapeutics. The event highlights the transformation in manufacturing operations, centered around digitalization, automation and sustainability.
In January 2025, the company extended its strategic collaboration with McMaster University to provide access to its new bioprocessing automation lab equipped with instruments and solutions of former company. The purpose of the partnership is to explore innovative modelling and predictive control solutions for accelerated biomanufacturing.

To know more about Sartorius and other digital biomanufacturing companies, access our full report.

Siemens Leverages its Expertise in Automation, Digitalization and Software to bring Transformation in the biopharmaceutical industry

5. Siemens

Siemens is technology developer primarily engaged in offering digital solutions to various sectors (including infrastructure, transport, healthcare and pharmaceutical sectors). Further, the company is dedicated to offering technologies which bridge the gap between real and digital world in order to help their client to evaluate and make informed decisions. Additionally, Siemens has developed cutting-edge digital twin technology, Siemens Xcelerator for the companies engaged in bioprocessing, to streamline manufacturing process, boost efficiency and achieve productivity. Further, the digital twin system enables the development and deployment of integrated end-to-end bioprocess models with multivariate experiments, facilitating efficient scale-up of the process.

Siemens offers multiple digital biomanufacturing technologies / software, including PAT and DAS.

Technology / Software Portfolio

The company offers an extensive range of technology / software with various capabilities that enable its clients to implement digitalization in their biomanufacturing operations. The capabilities of various technologies / software offered by Siemens include:

Process Analytical Technology Name	Details
SIMATIC SIPAT	Deployment Option: Web-based Technology Capabilities: Process Automation, Bioprocess Optimization and Controls, Data Integration, Process Monitoring and Visualization, Report Generation and Documentation Additional Capabilities: Enterprise Resource Planning (ERP) and Quality by Design (QbD) Approach Regulatory Compliance: FDA, EU, GMP

Digital Twin Name	Details
Xcelerator	Technology Capabilities: Process Modeling / Designing, Process Validation, Process Simulation, Process Optimization, Quality Control, Real-time Monitoring Type of Twin: Process Twin
Process Digital Twin	Technology Capabilities: Process Modeling / Designing, Process Simulation, Process Optimization, Quality Control, Real-time Monitoring Type of Twin: Process Twin Integrated Technology: Artificial Intelligence

Recent Developments

In September 2024, the company entered into a strategic agreement with Merck for driving digital transformation across the latter’s business sectors using Siemen’s Xcelerator platform.

To know more about Siemens and other digital biomanufacturing companies, access our full report.

What About Other Digital Biomanufacturing Companies Around the World?

The above article features top five digital biomanufacturing companies selected from a pool of more than 100 companies offering digital biomanufacturing technologies / software. If you are interested, you can download the Sample Report on this topic by Roots Analysis. For personalized assistance in identifying the most relevant solutions based on your specific criteria, please don't hesitate to reach out to us at sales@rootsanalysis.com.

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