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The global exosome therapy market is estimated to be USD 32 million in 2022 and is anticipated to grow at a compounded annual growth rate (CAGR) of 41.1% during the forecast period. In recent years, therapies utilizing extracellular vesicles have garnered significant attention among the industry stakeholders for the treatment of diverse indications, primarily owing to the various benefits offered by them, including target specificity, enhanced tissue regeneration, and reduced inflammation and chronic pain. Over time, various research studies have demonstrated the potential of exosomes (membrane bound extracellular vesicles) in disease diagnosis, drug delivery and therapeutic applications. Currently, both industry and non-industry players are attempting to develop exosome therapeutics for disease management, some of which are already in clinical trials. Moreover, post the onset of the COVID-19 pandemic, there has been a steady increase in the investigational new drug (IND) applications filed for exosome therapy. In a recent review of more than 200 studies evaluating mesenchymal stem cell (MSC) derived exosomes for preclinical use, the exosomes demonstrated benefits in more than 70% of studies.
The Exosome Therapy Market, Distribution by Type of Therapeutic (Allogeneic and Autologous), Target Indication (Degenerative Meniscal Injury, Dystrophic Epidermolysis Bullosa, Fistula Perianal and Retinitis Pigmentosa), Therapeutic Area (Dermatological Disorders, Musculoskeletal Disorders, Ophthalmic Diseases and Rectal Disorders), Route of Administration (Fistula Tract, Intra-articular and Intra-ocular) and Geography (North America, Europe, Asia-Pacific and Rest of the World): Industry Trends and Global Forecasts, 2022-2040 report features an extensive study of the current market landscape, market size and future outlook for the companies involved in developing exosome therapy. The market report answers many key questions related to this industry.
The exosome therapy market is presently growing at a significant pace among the dynamic sectors of pharmaceutical industry. At present, the pipeline features close to 120 therapeutic candidates, and this number is anticipated to grow further in the forecast period. More than 40% of the total number of drugs are in clinical stage of development. Of the total candidates, seven exosome therapies, including EXOMSC-COV19 (Dermama Biotech Lab), Dex2 (Gustave Roussy Institute), SF-MSC-EX (Osmangazi University), are currently being evaluated in the advanced clinical stages of development.
Further, around 30% of the exosome therapeutics are being developed for treatment of cancer. Exosome based therapy for cancer is a novel approach and the drugs are currently in early stages of development. Breast cancer, lung cancer, melanoma and colon cancer are amongst some of the oncological indications where exosomes are being tested as delivery vehicles for targeted therapy.
Over time, more than 60 pharmaceutical companies and academic / research institutes have undertaken various initiatives to develop effective exosome therapies against multiple target indications. Moreover, multiple collaborations have been inked between both industry and non-industry players in order to advance the efforts in research and development of various pipeline candidates, over the past decade. In one such agreement signed in June 2022, Coya Therapeutics in licensed an exosome engineering technology from Carnegie Mellon University. The company gained worldwide rights to the exosome polymer hybrid technology that allows targeted delivery of the exosomes carrying drug of interest. Their first exosome therapy, COYA 206, based on this in licensed technology is currently in early research.
In the last five years, capital investments worth around USD 500 million have been made by strategic investors for the research and development of exosome therapeutics. These funds have been raised through 35 number of instances, equating to an average of USD 16 million per funding round. In the most recent instance, Mantra Bio announced a USD 9 million Series A-2 round in January 2023. The company is developing targeted exosome therapeutics for ophthalmology and infectious disease.
Despite the numerous benefits offered by exosome therapies, developers often face concerns related to the weak therapy preparations, bacterial infections, and contamination with non-exosomal components. Additionally, the heterogeneous nature of such extracellular vesicles (EVs) is one of the major challenges faced during the quantification and characterization of the required EVs from a diverse population of cells. In order to mitigate the aforementioned challenges, novel technologies are being adopted by several stakeholders.
The exosome therapeutics market is currently valued at USD 32 million in 2022. The market is projected to grow at a CAGR of more than 40%, with anticipated release of a number of therapies during the forecast period. In terms of route of administration, the market is likely to be driven by exosome therapeutics designed for intra-ocular administration. Further, in terms of therapeutic area, majority share of the revenues is expected to be generated by ophthalmic diseases. Specifically, in terms of geography, the exosome therapeutics market in Asia-Pacific is likely to grow at a significant pace, in the long term.
The factors contributing to the growth of exosome therapeutics market include increasing disease burden, rise in research and development activities for exosome therapeutics, and government funding for the production of exosome therapy. Moreover, the growth potential in the emerging economies will bolster the exosome therapeutics market growth during the forecast period.
In March 2023, one of the well-known companies in the exosome therapy industry, Codiak BioSciences filed for bankruptcy. The company had two clinical stage exosome therapy and a preclinical stage molecule targeting cancer. According to Codiak BioSciences, the company did not have sufficient funds to carry forward the development of the molecules. This instance also reflects upon the smaller amount of funds that the developers are able to raise, which may not be sufficient once the pipeline moves into clinical trials.
Additionally, seven exosome therapeutics under development against various indications, primarily cancer, have been withdrawn due to limited or no patient enrollment, non-adherence to dosage regimen and financial constraints. In absence of availability of sufficient funds, the exosome therapy market is likely to witness events that can restrain the market growth.
The key companies engaged in this market (which have also been capture in this report) include Cellular Biomedicine Group, Coya Therapeutics, Curexsys, EV Therapeutics, Evox Therapeutics, ExoCoBio, ILIAS Biologics, Rion and SHIFTBIO. This market report includes an easily searchable excel database of all the companies and academic institutes developing exosome therapy.
Several recent developments have taken place in the field of exosome therapy market. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.
The market report presents an in-depth analysis, highlighting the diverse capabilities of players engaged in this industry, across different geographies as defined in the below table:
|Key Report Attributes
Market Size 2022
Type of Exosome Therapeutics
Target Disease Indications
Degenerative Meniscal Injury, Dystrophic Epidermolysis Bullosa, Fistula Perianal, Retinitis Pigmentosa
|Dermatological Disorders, Musculoskeletal Disorders, Ophthalmic Disorders
|Type of Formulation
|Route of Administration
Fistula Tract, Intra-articular, Intra-ocular
North America, Europe, Asia-Pacific and Rest of the World
|Key Companies Profiled
|Coya Therapeutics, Evox Therapeutics, Curexsys, EV Therapeutics, SHIFTBIO
|15% Free Customization Option
|PowerpPoint Presentation (Complimentary)
|Excel Data Packs
|Market Landscape Analysis, Company Competitiveness Analysis, Patent Analysis, Recent Developments, Market Forecast and Opportunity Analysis
Amongst other elements the research report includes:
One of the key objectives of the market report was to identify the primary growth drivers and estimate the future growth opportunity associated with exosome therapy market in the mid to long term. Based on various parameters, such as historical sales, target patient population, likely adoption rates and expected pricing, we have provided informed estimates on the likely evolution of the market for the forecast period 2029-2040. Our year wise projections of the current and forecasted opportunity within the exosome therapeutics market have further been segmented across type of therapeutic (allogeneic and autologous), target disease indication(s) (degenerative meniscal injury, dystrophic epidermolysis bullosa, fistula perianal and retinitis pigmentosa), therapeutic area (dermatological disorders, musculoskeletal disorders, ophthalmic diseases and rectal disorders), route of administration (fistula tract, intra-articular and intra-ocular), geography (North America, Europe and Asia-Pacific and Rest of the World). In order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, portraying the conservative, base and optimistic tracks of the market’s evolution.
The opinions and insights presented in the market report were influenced by discussions held with several stakeholders in exosome industry. The research report features detailed transcripts of interviews held with the following individuals (in alphabetical order of company / organization names):
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.