Glycan Analysis Market

Glycan Analysis Market by Company Size, Analytical Techniques and Key Geographical Regions: Industry Trends and Global Forecasts, 2021-2030

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Glycan Analysis Market Overview

The glycan analysis market is estimated to be worth $456 million in 2021 and is expected to grow at CAGR of 20.8% during the forecast period. Recombinant glycoprotein therapeutics, which include antibody-based interventions, have emerged as one of the fastest growing classes of pharmacologically active molecules. Till date, over 67% of biologics and 80% of biosimilars approved by the FDA, feature some form of glycosylation. In fact, the pipeline of such interventions is also growing at a commendable pace (CAGR of over 20%).

It is important to highlight that for higher eukaryotes, such as humans, DNA glycosylation of certain biomolecules is not only important from the functional perspective, but it also imparts beneficial pharmacological properties, which influence efficacy, solubility, stability, and antigen binding. Further, glycans represent a promising class of biomarkers that are useful for disease prognosis, diagnosis, and assist in the prediction of treatment efficacy. In this context, several tumor-associated (aberrant) glycan molecules (such as Tn, sialyl-T and sialyl-Tn), as well as virulent glycoproteins on pathogenic viral envelopes (such as the glycan shield associated with the SARS-CoV-2 spike glycoprotein), are presently being investigated as viable therapeutic targets.

Given the complexities associated with glycan analysis, it is difficult for non-specialist researchers and therapy developers, to effectively analyze this aspect of biomolecules. Moreover, the associated analytical procedures are further complicated by multi-step analytical protocols and technically demanding expertise, which eventually lead to contamination of samples and lack of reproducibility in test results. Recent evolution in the approach (such as the use of orthogonal techniques and the middle-up strategy) to analyzing data generated from the diverse bioanalytical techniques used in glycan profiling and glycan analysis, necessitate extensive domain expertise. Consequently, drug developers and medical researchers are increasingly relying on contract service providers with the necessary analytical expertise and technical infrastructure, for their glycan analysis needs.

Currently, more than 130 industry and non- industry players claim to be actively providing glycan analysis services. In the recent past, a number of stakeholders in the services sector, have forged strategic alliances with and / or acquired other players offering glycan analysis of monoclonal antibody or related services, in order to further enhance their respective portfolios. Considering the growing trend of outsourcing and the ongoing efforts of service providers to improve / expand their respective offerings, we believe the contract services market for glycan analysis is likely to witness a steady market growth during the forecast period.

Key Companies in Glycan Analysis Market

Examples of key companies engaged in glycan analysis market (which have also been profiled in this market report; the complete list of companies is available in the full report) include CD BioGlyco, Creative Biolabs, Creative Proteomics, Thermo Fisher Scientific, Glykos Finland, glyXera, Ludger, Protagen Protein Services, Mithra Biotechnology, Protein Works, Savyon Diagnostics and Syngene. This market report includes an easily searchable excel database of all the companies providing protein DNA glycosylation analysis services, worldwide.

Recent Developments in Glycan Analysis Market:

Several recent developments have taken place in the field of glycan analysis market. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.

  • In September 2023, CellKey entered into a collaboration with Emerald Cloud Lab with an aim to co-develop advanced glycoprotein analysis platform.

Scope of the Glycan Analysis Market Report

The “Glycan Analysis Market, 2021- 2030” market report features an extensive study on the current market landscape, market size, market share, market forecast, market outlook and future opportunities of the glycan analysis market. The market research report underlines an in-depth analysis of the various services offered for assessing glycosylation related attributes, in biopharmaceutical, biomedical and clinical samples.

Glycan Analysis Market Context Glycan Analysis Market, List of Surface Glycan Glycan Analysis Market, Distribution by Type of Analytical Technique

 

Amongst other elements, the market research report includes:

  • A detailed review of the overall landscape of the glycan analysis services market, highlighting the contributions of industry players, along with the information on their year of establishment, company size, geographical location of headquarters, type of service(s) offered (glycan profiling and heterogeneity analysis, glycosylation site mapping and occupancy analysis, site- specific glycosylation analysis, glycan structure analysis, monosaccharide quantification analysis and protein- glycan binding analysis), type of glycoconjugate and glycan analyzed (N- glycan, O- glycan and glycolipid), type of sample analyzed (biotherapeutics and cellular), type of analyte processed (intact glycoprotein, glycopeptide, released glycan, monosaccharide and polysaccharide), type of analytical technique used (chromatography, spectroscopy, electrophoresis and microarray- based technique), application area (R&D / early- stage drug development and in- process drug development) It also provides information on the additional services offered (peptide mapping, post- translational modification analysis, protein terminal sequencing and glycan / glycoconjugate synthesis), and availability of synthetic glycans and analytical kits / tests.  In addition, it provides information on the type of glycoanalytical service offered and type of technique used by non-industry players.
  • A region-wise company competitiveness analysis, highlighting the most prominent glycan analysis service providers, based on their supplier strength (in terms of experience and company size), and portfolio specifications (in terms of number of services offered, number of analytical techniques used, types of glycans analyzed, types of analytes processed and applications).
  • Elaborate profiles of prominent service providers in glycan analysis market. Each company profile includes a brief overview of the company, its financial information (if available), information on service portfolio, recent developments, and an informed future outlook.
  • A detailed assessment of the current market landscape of surface glycan targeting therapeutics, providing information on the phase of development (commercial, clinical, preclinical, and discovery) of lead candidates, target disease indication and therapeutic area, type of drug molecule (antibody, antibody-drug conjugate, enzyme, glyco- conjugate vaccine and CAR- T cells), target glycan / glycoconjugate molecule, type of therapy (monotherapy, combination therapy and both), and technology platform used. In addition, it provides details on drug developer(s), including information on their year of establishment, company size, and location of headquarters.
  • A detailed analysis of grants that have been awarded to research institutes for surface glycan targeting therapeutic projects, during the period, 2016 and 2021, based on several relevant parameters, such as year of grant award, amount awarded, administering institute center, support period, type of grant application, purpose of grant award, activity code, study section involved, type of recipient organizations and focus area. In addition, it highlights geographical distribution of recipient organizations, popular funding institute centers, prominent program officers, and popular recipient organizations.
Glycan Analysis Market, Geographical Distribution Glycan Analysis Market, 3D Bubble Analysis Glycan Analysis Market, Services Providers

 

  • An analysis of the partnerships that have been established in glycan analysis market since 2015, covering instances of acquisitions and mergers, licensing agreements, product development agreements, process development agreement, research agreements, and other relevant types of deals.
  • A detailed analysis of the various mergers and acquisitions that have taken place in glycan analysis market, highlighting the trend in the number of companies acquired during the time period between 2015- 2021, based on several relevant parameters, such as year of agreement, type of deal, geographical location of headquarters, company size, and the key value drivers. In addition, it represents an ownership change matrix, providing a summary of the involvement of private and public sector entities in glycan analysis market.
  • A case study on the potential clients of glycan analysis services providers; it presents a list of Fc glycoengineered antibody developers, along with information on their year of establishment, company size, and location of headquarters. In addition, it provides information on phase of development of the glycoengineered antibody, target disease indication, therapeutic area, type of molecule, its biological target, type of therapy, route of administration, impact of Fc engineering and technology platform used.

The key objective of glycan analysis market report is to provide a detailed market analysis in order to estimate the existing market size, market value, statistics and future opportunity for glycan analysis market during the forecast period. Based on various parameters, such as the number of projects completed annually, price of the projects, the overall R&D expenditure available to CROs and the overall growth of the glycoprotein therapeutics market, we have developed informed estimates on the evolution of the market for the forecast period 2021-2030. Our year-wise projections of the current and forecasted opportunity have further been segmented across company size (small, mid-sized and large), analytical techniques used (spectroscopy, chromatography, microarrays and electrophoresis), key geographical locations (North America, Europe and Asia- Pacific). In order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, portraying the conservative, base and optimistic tracks of the market’s evolution.

Glycan Analysis Market, Distribution by Phase of Development Glycan Analysis Market, Grant Analysis Glycan Analysis Market, Partnerships and Collaborations


The opinions and insights presented in the market report were influenced by discussions held with several key players in glycan analysis market. The market research report features detailed transcripts of interviews held with the following industry stakeholders:

  • Technical Director, US based University
  • Founder and Chief Executive Officer, a Small Company, Germany
  • Chief Executive Office, a Small Company, Finland

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this market research report are in USD, unless otherwise specified.

Frequently Asked Questions

Question 1: What is protein glycosylation?

Answer: Protein glycosylation is the covalent binding of multi-sugar polysaccharides or complex oligosaccharides, to specific target protein residues. For higher eukaryotes, such as humans, glycosylation of certain biomolecules is not only important from the functional perspective, but it also imparts beneficial pharmacological properties.

Question 2: How big is the glycan analysis market?

Answer: The glycan analysis market size is estimated to be worth $456 million in 2021.

Question 3: What is the projected market growth of the glycan analysis market?

Answer: The glycan analysis market is expected to grow at compounded annual growth rate (CAGR) of 20.8% during the forecast period.

Question 4: Who are the leading service providers in the glycan analysis market?

Answer: Examples of key companies engaged in glycan analysis market (which have also been profiled in this market report; the complete list of companies is available in the full report) include CD BioGlyco, Creative Biolabs, Creative Proteomics, Thermo Fisher Scientific, Glykos Finland, glyXera, Ludger, Protagen Protein Services, Mithra Biotechnology, Protein Works, Savyon Diagnostics and Syngene.

Question 5: How many companies are currently engaged in glycan analysis market?

Answer: Over 130 companies are currently engaged in the glycan analysis market, offering analysis services for identifying glycosylation patterns of biological samples.

Question 6: How many partnership deals have been inked between stakeholders engaged in the glycan analysis market?

Answer: More than 100 partnership deals have been inked between stakeholders engaged in the glycan analysis market, highlighting the consolidation efforts of the players.

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