Protein Expression Market

Protein Expression Market: Industry Trends and Global Forecasts, Till 2035: Distribution by Type of Protein Expression System (Algal, Cell-free, Insect, Mammalian, Prokaryotic and Yeast), Protein Expression-related Offerings (Competent Cells, Expression Vectors, Instruments, Kits and Reagents, and Protein Expression Services), Application Area (Research and Diagnostics, and Therapeutics), End-users (Academic and Research Institutes, CROs and CDMOs, Pharmaceutical / Biotechnology Companies, and Other End-users), Type of Operation (In-house and Outsourced Operations), Geography(North America, Europe, Asia-Pacific, Latin America and Middle East and North Africa) and Key Players

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Protein Expression Market Overview

The protein expression market size is projected to grow from $2.7 billion in 2024 to $6.3 billion by 2035, representing a CAGR of 8.0%, during the forecast period 2024-2035.

Protein Expression Market By Type of Protein Expression System, 2020-2035 (USD Billion)

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The new research study consists of industry trends, brief market analysis, competitive landscape, value chain analysis and market impact analysis. The report also includes market forecast and opportunity analysis.

Proteins are complex macromolecules made up of long chains of amino acids, having crucial role in drug discovery, therapeutics and diagnostics. Over the years, proteins have become increasingly important for their application as therapeutic candidates, owing to their versatility, enhanced metabolic stability, biological target specificity and higher affinity. It is important to note that in 2023, 50% of the top ten selling drugs were protein therapeutics. In 2023 alone, close to 20 protein therapeutics have been approved by the USFDA, for the treatment of myriad of chronic diseases, including cancers, immune disorders, infections, and diabetes. Moreover, since 2023, more than 6,500 patents related to protein expression have been granted.

The growing research activity in this domain and surge in demand for protein therapeutics has prompted the pharmaceutical players to actively adopt protein expression systems for the production of various recombinant proteins. These systems offer several advantages, including the ability to produce a broad range of target molecules, by altering components suited for their production, higher yield, shorter development time and low cost of production. In addition, a number of players have also developed kits and reagents for the expression of proteins. These products have enabled the synthesis of several complex proteins, including toxic proteins, membrane proteins and other post translationally modified proteins.

Therefore, over the forecast period, owing to the rising incidence of chronic diseases, increasing demand for protein therapeutics, maturation of protein-based leads into the clinic and / or commercialized stage, and development of advanced expression systems, the protein expression market is anticipated to witness healthy growth.

Protein Expression Market Share Insights

The market research report presents an in-depth analysis of various protein expression product and service providers that are involved in global protein expression industry, across different segments, as defined in the table below: 

Protein Expression Market: Report Attributes / Market Segmentations

Key Report Attributes Details
Historical Trend 2020-2023
Base Year 2023
Forecast Period 2024-2035
Market Size 2024 $ 2.7 Billion
Market Size 2035 $ 6.3 Billion
Growth Rate CAGR of 8.0% from 2024 to 2035
Type of Protein Expression System
  • Algal Expression Systems
  • Cell-free Expression Systems
  • Insect Expression Systems
  • Mammalian Expression Systems
  • Prokaryotic Expression Systems
  • Yeast Expression Systems
Protein Expression-related Offerings
  • Competent Cells
  • Expression Vectors
  • Instruments
  • Kits and Reagents
  • Protein Expression Services
Application Area
  • Research and Diagnostics
  • Therapeutics
End Users
  • Academic and Research Institutes
  • CROs and CDMOs
  • Pharmaceutical and Biotechnology Companies
  • Other End-users
Type of Operation
  • In-house Operations
  • Outsourced Operations
Geography
  • North America (US and Canada)
  • Europe (France, Germany, Italy, Spain, UK and Rest of Europe)
  • Asia-Pacific (India, China, Japan, South Korea and Rest of Asia-Pacific)
  • Latin America
  • Middle East and North Africa
Key Companies Profiled in the
Protein Expression Market
  • Agilent Technologies
  • Ajinomoto Bio-Pharma Services
  • Aldevron
  • Cayman Chemical
  • Charles River Laboratories
  • Domainex
  • Eurofins CALIXAR
  • GeNext Genomics
  • GenScript Biotech
  • Lonza 
  • Merck KGaA
  • New England Biolabs
  • ProMab
  • Promega 
  • ProteoGenix
  • QIAGEN
  • Sartorius
  • Synbio Technologies
  • Syngene
  • Takara Bio
  • Thermo Fisher Scientific
  • WuXi Biologics
Customization Scope 15% Free Customization 
Excel Data Packs
(Complimentary)
  • Market Landscape Analysis
  • Company Competitiveness Analysis
  • Market Size and Opportunity Analysis

One of the key objectives of this market report was to estimate the current market size, opportunity and the future growth potential of the protein expression product and service providers, over the forecast period. Based on multiple parameters, likely adoption trends and through primary validations, we have provided an informed estimate on the market evolution during the forecast period 2024-2035.

The market report also features the likely distribution of the current and forecasted opportunity for protein expression product and service providers in the overall market across various segments, such as type of protein expression system (algal, cell-free, insect, mammalian, prokaryotic and yeast), protein expression-related offerings (competent cells, expression vectors, instruments, kits and reagents, and protein expression services), application area (research and diagnostics, and therapeutics), end-users (academic and research institutes, CROs and CDMOs, pharmaceutical / biotechnology companies, and other end-users), type of operation (in-house and outsourced operations), Geography(North America, Europe, Asia-Pacific, Latin America, and Middle East and North Africa) and key players. In order to account for future uncertainties associated with some of the key parameters and to add robustness to our model, we have provided three protein expression market forecast scenarios, namely conservative, base, and optimistic scenarios, representing different tracks of the industry’s evolution.

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this market report are in USD, unless otherwise specified.

Protein Expression Market Key Segments

Market Share by Type of Protein Expression System

The global protein expression market is segmented into different types of protein expression systems such as algal, cell-free, insect, mammalian, prokaryotic and yeast expression systems. The mammalian expression system occupies the highest share in 2024 and is expected to remain dominant during the forecast period. This can be attributed to the fact that mammalian cells possess the ability to produce mammalian proteins that have native structure and high levels of post-translational modifications and functional activity. It is worth highlighting that, close to 85% of the biopharmaceuticals are produced using mammalian cell cultures.

Market Share by Protein Expression-related Offerings

The global protein expression market is segmented into different types of protein expression-related offerings, such as competent cells, expression vectors, instruments, kits and reagents, and protein expression services. Given that kits and reagents aid in optimizing protein expression by incorporating solubility tags, purification tags, and protease cleavage sites, these hold the largest market share in 2024 . Further, the development of novel competent cell strains and custom expression vectors are expected to drive growth in the overall protein expression industry.

Market Share by Application Area

The global protein expression market is segmented into different application areas, such as research and diagnostics, and therapeutics. It is worth highlighting that the market share for therapeutics is likely to grow at a higher CAGR in the coming years as compared to the research and diagnostics applications of protein expression. This can be attributed to the versatility, efficacy, and ability of protein therapeutics to target complex disorders, thereby offering a promising avenue for innovative drug development and addressing unmet medical needs.

Market Share by Type of End-user

The global protein expression market caters to a variety of end-users, including academic and research institutes, CROs and CDMOs, pharmaceutical and biotechnology companies and other end-users. Pharmaceutical and biotechnology companies capture the highest share in 2024 and are expected to dominate the market during the forecast period. Owing to ongoing advancements in protein expression technologies and growing demand for protein-based therapeutics, the revenues generated from manufacturing of proteins by pharmaceutical and biopharmaceutical companies is expected to grow substantially as compared to other end-users. 

Market Share by Type of Operation

The global market for protein expression is segmented into different types of operations, including in-house and outsourced operations for producing proteins. It is worth highlighting that owing to various benefits of undertaking protein production initiatives in-house, such as improved efficiency, stringent quality control, protected intellectual property and minimal supply chain disruptions, market for protein expression for in-house operations is likely to grow at a higher CAGR in the coming years as compared to the outsourced operations.

Market Share by Geography

The global protein expression market is segmented across various geographies, such as North America, Europe, and Asia-Pacific, Latin America and Middle East and North Africa. According to our projections, North America captures the majority share (50%) of the market opportunity, and this trend is unlikely to change during the forecast period. This can be attributed to the expedited approval timelines, technical advancements and expansions related to protein expression in developed countries, such as the US. It is worth highlighting that the market for protein expression in Asia-Pacific is expected to grow at a relatively higher CAGR (10.0%), during the forecast period, 2024-2035.

Protein Expression Market Key Insights

The “Protein Expression Market: Industry Trends and Global Forecasts, Till 2035” report features an extensive study of the current market landscape, market size and future opportunities associated with protein expression product and service providers within the protein expression industry, during the given forecast period. The market report highlights the efforts of several stakeholders engaged in this rapidly emerging segment of the pharmaceutical industry. Key takeaways of the market report are briefly discussed below.

Competitive Landscape of Protein Expression Product and Service Providers

The current market landscape seems to be well-fragmented, featuring the presence of both new entrants and established players. Stakeholders in this domain offer various types of protein expression systems, vectors, competent cells, and kits and reagents, across different application areas including industrial, research and therapeutic. The majority of the protein expression product and service providers offer prokaryotic expression systems, owing to its low cost, high expression yield and ease of scale-up. This is followed by mammalian expression systems. Further, it is worth highlighting that more than 80% of the players offer protein expression services. 

It is interesting to highlight that in order to meet the increasing demand for protein therapeutics, the companies engaged in protein expression domain have undertaken several initiatives, such as entering into strategic collaborations, and expanding their existing capabilities / product portfolios. 

Protein Expression Market Trends

Emergence of cell free protein expression systems has facilitated the synthesis of several complex proteins, including toxic proteins, membrane proteins and other post translationally modified proteins, which were challenging to express using conventional cell-based systems. Further, owing to some major advances in synthetic organic chemistry, plant based protein expression systems have emerged as a promising alternative for protein synthesis over other expression systems. Plant-host engineering facilitates the production of proteins with distinct and uniform post translational modifications, demonstrating higher effectiveness. 

In addition, integration of computational biology and machine learning, are helping to design  exceptional protein expression systems. Moreover, technology-driven changes such as in silico prediction and development of drugs and antibiotics are further transforming the protein expression landscape, offering a competitive edge to the overall market.

Protein Expression Market Drivers

The protein expression market growth is primarily driven by the growing pipeline of protein-based therapeutics, being developed for the treatment of a myriad of disease indications including oncological, cardiovascular and metabolic disorders. There has been constant evolution in protein based therapeutics as well, with some companies also evaluating oral proteins and peptides for therapeutic applications. In addition, increasing demand for personalized and precision therapies have emerged as the key drivers for the growing adoption of such solutions in the overall pharma market. It is anticipated that over 10 novel personalized therapeutic modalities will be approved by the US FDA each year till 2025.

Presently, therapy developers are constantly looking out for opportunities to leverage the protein expression solutions offered by protein expression product and service providers, in order to streamline their development process and cater to the rising demand for personalized therapies. Further, technological advancements in the domain, including novel expression systems, microfluidics, alternative expression hosts, and high throughput genome editing techniques, are expanding the efficiency of protein expression process, thereby fueling the adoption of protein expression technologies in the pharmaceutical industry.  

Global Protein Expression Market Size Analysis: Mammalian Expression Systems to Drive Market Growth

The global market opportunity for protein expression product and service providers is estimated to be worth USD 2.7 billion in 2024, driven by the rapidly increasing demand for protein therapeutics. In terms of type of protein expression system, the market for mammalian expression system is anticipated to capture the largest market share, during the forecast period, 2024-2035. The market growth is primarily fueled by their applicability in diverse research purposes, notably in studying protein functions, owing to their ability to offer superior post translational modifications and functional protein activity.

Regional Analysis: North America Emerges as the Hub of Protein Expression Market; Asia-Pacific to be the Fastest Growing Market

Currently, North America and Europe capture around 75% of the protein expression market share. Considering the expedited approval timelines, technical advancements and expansions related to protein expression in developed countries, such as the US, North America is expected to dominate the overall market. Further, the market in Europe is anticipated to show substantial growth, owing to rising prevalence of various disease indications, such as diabetes and cancer across the region. It is worth highlighting that the market in Asia-Pacific is likely to grow at a higher rate owing to the lower manufacturing costs, cheap and skilled labor and supportive regulatory landscapes in this region.

Leading Protein Expression Product and Service Providers in the Industry

Examples of key protein expression product and service providers involved in the protein expression industry (which have also been captured in this market report, arranged in alphabetical order) include Agilent Technologies, Ajinomoto Bio-Pharma Services, Aldevron, Cayman Chemical, Charles River Laboratories, Domainex, Eurofins CALIXAR, GeNext Genomics, GenScript Biotech, Lonza, Merck KGaA, New England Biolabs, ProMab, Promega, ProteoGenix, QIAGEN, Sartorius, Synbio Technologies, Syngene, Takara Bio, Thermo Fisher Scientific and WuXi Biologics. This market report includes an easily searchable excel database for all the companies offering protein expression-related products / services for various industrial, research and therapeutic applications.

Protein Expression Market Report Coverage

The market report presents an in-depth analysis, highlighting the capabilities of various protein expression product and service providers in this market, across different segments. Amongst other elements, the market report includes:

  • A preface providing an introduction to the full report, Protein Expression Market: Industry Trends and Forecasted Estimates, till 2035.
  • An outline of the systematic research methodology adopted to conduct the study on protein expression industry, providing insights on the various assumptions, methodologies, and quality control measures employed to ensure accuracy and reliability of our findings.
  • An overview of economic factors that impact the overall protein expression market, including historical trends, currency fluctuation, foreign exchange impact, recession, and inflation measurement.
  • An executive summary of the insights captured during our research. It offers a high-level view on the current state of protein expression and its likely evolution in the mid-long term.
  • A general overview of protein expression, its process and various applications of protein expression. It also features details on different types of protein expression systems with their key features and applications. Further, it provides information on the different challenges associated with protein expression, along with the recent trends related to protein expression. 
  • A detailed assessment of protein expression product and service providers, along with information on several relevant parameters, such as year of establishment, company size (in terms of employee count) and location of headquarters (region and country), type of protein expression systems (algal, cell-free, insect, mammalian, prokaryotic and yeast expression systems), protein expression-related offerings (competent cells, expression vectors, instruments, kits and reagents and protein expression services) and application areas (industrial, research and therapeutic). 
  • An insightful competitiveness analysis of protein expression product and service providers, based on several relevant parameters, such as developer strength (in terms of number of years of experience of a company and company size) and portfolio strength (in terms of type of protein expression system offered, number of protein expression-related offerings and number of application areas). Further, the report also presents a benchmarking analysis, highlighting the key focus areas of these companies, comparing their existing capabilities amongst the competing players.
  • Elaborate profiles of key companies engaged in the protein expression market. Each profile features a brief overview of the company (including information on year of establishment, location of headquarters, number of employees, management team and business segments), protein expression-related offerings, financial information, recent developments and an informed future outlook.
  • An in-depth value chain analysis featuring a discussion on various stakeholders involved in the protein expression, from supplier to end-users. Further, it also provides information on protein expression process from design to large scale production.
  • A comprehensive analysis of the factors that can impact the growth of the market for protein expression. It also features identification and information on key drivers, potential restraints, emerging opportunities, and existing challenges.
  • A detailed estimate of the current market size and the future growth potential of the protein expression market over the next decade. Based on multiple parameters, such as likely adoption trends and through reliable secondary and primary validations, we have provided an informed estimate on the market evolution during the forecast period 2024-2035. The report also features the likely distribution of the current and forecasted opportunity within the protein expression industry. Further, in order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, namely conservative, base, and optimistic scenarios, representing different tracks of the market growth.
  • Detailed projections of the current and future opportunity within protein expression market across different types of protein expression systems, such as algal, cell-free, insect, mammalian, prokaryotic and yeast expression systems.
  • Detailed projections of the current and future opportunity within protein expression domain across various protein expression-related offerings, such as competent cells, expression vectors, instruments, kits and reagents and protein expression services.
  • Detailed projections of the current and future opportunity within protein expression industry across various application areas, such as research and diagnostics, and therapeutics.
  • Detailed projections of the current and future opportunity within protein expression market across different end-users, such as academic and research institutes, CROs and CDMOs, pharmaceutical and biotechnology companies and other end-users.
  • Detailed projections of the current and future opportunity within market for protein expression across different types of operation, such as in-house operations and outsourced operations.
  • Detailed projections of the current and future opportunity within protein expression market across various geographies, such as North America (US and Canada), Europe (France, Germany, Italy, Spain, UK and Rest of Europe), Asia-Pacific (India, China, Japan, South Korea and Rest of Asia-Pacific), Latin America and Middle East and North Africa.
  • A detailed discussion on the key protein expression product and service providers in this industry, highlighting their protein expression portfolio and annual revenues of business segment that includes protein expression.

Recent Developments in Protein Expression Market

Several recent developments have taken place in the market, some of which have been outlined below. These developments, even though they took place post the release of our market report, substantiate the overall market trends that we have outlined in our analyses.

  • In May 2024, GenScript Biotech participated in the Cambridge Healthtech Institute's 14th Annual Optimizing Protein Expression conference, held in Massachusetts, US.  In addition, in April 2024, the company participated in AACR Annual Meeting to showcase its protein expression platforms, held in California, US.
  • In March 2024, Merck KGaA expanded its protein expression capabilities through the opening of a new bioprocessing production center for the development and production of biologics, in South Korea, China.
  • In January 2024, key protein expression players including Agilent Technologies and Ajinomoto Bio-Pharma Services participated in the Cambridge Healthtech Institute’s 26th Annual Recombinant Protein Expression & Production Conference to showcase their capabilities in the protein expression domain, held in California, US.

Authors: Akarshika Singh, Dhriti Gulati and Aashima Bhalla

Frequently Asked Questions

Question 1: What is protein expression?

Answer: Protein expression, also referred to as protein production is a biotechnological process for producing specific proteins for research or commercial use.

Question 2: What is the market size for protein expression?

Answer: The protein expression market size is estimated to be worth $2.7 billion in 2024.

Question 3: What is the growth rate (CAGR) of the protein expression market?

Answer: The protein expression industry is expected to grow at an annualized growth rate (CAGR) of 8.0% during the forecast period, 2024-2035.

Question 4: How big is the mammalian expression system market?

Answer: The mammalian expression system market size is anticipated to be worth $ 1.3 billion in 2024.

Question 5: Which region has the highest share of the protein expression market?

Answer: Currently, North America and Europe collectively capture around 75% of the market share.

Question 6: Who are the leading players engaged in the protein expression industry?

Answer: Agilent Technologies, Ajinomoto Bio-Pharma Services, Aldevron, Cayman Chemical, Charles River Laboratories, Domainex, Eurofins CALIXAR, GeNext Genomics, GenScript Biotech, Lonza, Merck KGaA, New England Biolabs, ProMab, Promega Corporation, ProteoGenix, QIAGEN, Sartorius, Synbio Technologies, Syngene, Takara Bio, Thermo Fisher Scientific and WuXi Biologics.

Question 7: What are the key factors driving the protein expression market?

Answer: The increasing prevalence of chronic diseases that require innovative protein therapeutics, rising protein based industrial biotechnology applications including biofuels and biopolymers, and the ongoing innovations in protein expression systems.

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