Single Use Bioreactors Market

Global Single Use Bioreactors Market Size

The single use bioreactors market, valued at USD 4.32 billion in 2025, is projected to reach USD 4.81 billion in 2026 and USD 10.48 billion by 2035, with a CAGR of 9.03% during the forecast period, 2026 to 2035.

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Single-use bioreactor, also known as disposable bioreactor, employs single use bioreactor bags instead of stainless-steel culture vessel for the manufacturing of various biologic. These bioreactors offer various advantages over conventional bioreactors, such as cost efficiency (~40%), shorter production timeline (~35%), reduction in energy and water consumption (45%-50%), better product yield and low risk of contamination.

Over the past few years, biopharmaceuticals have gained significant attention; over 170 biologics have received the US FDA approval, while over 10,000 biologics are currently under different stages of development. To fulfill the growing demand for biologics, such as high quality antibodies, cell therapies, gene therapy, a gradual shift towards the use of a single use bioreactor has been observed.

Many single use bioreactor manufacturers are focusing on incorporating a variety of advanced features, including provisions for alerts / alarms, electronic process logs, built-in system process control sensors, touch screens, remote monitoring features, and advanced safety provisions in their offerings to develop more efficient bioreactors for global markets. These control and monitoring functions are core elements of bioprocess automation in single-use manufacturing workflows.

Single-Use Bioreactors Market: Report Attributes

Key Report Attributes	Details
Historical Trend	Since 2022
Forecast Period	Till 2035
Market Size 2026	$4.81 Billion
Market Size 2035	$10.48 Billion
CAGR	9.03%

The single use bioreactor market analysis also features the likely distribution of the current and forecasted opportunity across various segments, such as type of bioreactor, scale of operation, type of cell culture, type of biologics synthesized, end users and geographical regions.

In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of single use bioreactors market growth.

The ongoing technological advancements focused on the development of improved versions of biosensors and single use bioreactor bags are likely to encourage the biopharmaceutical companies to adopt disposable bioreactors for continuous bioprocessing, representing a lucrative opportunity for companies engaged in this growing market.

Recent Developments in Single-Use Bioreactors Market

Several recent developments have occurred in the field of single use bioreactors, and we outline some of these below. These developments, even if they arose after our market report’s release, support the overall single use bioreactors market trends detailed in our analysis.

• In August 2026, Cobetter launched its Lifecask™ RT Single-Use Bioreactor Bag, expanding its upstream bioprocessing portfolio. The product is designed for biopharmaceutical manufacturers seeking scalable and flexible single-use operations. 
• In July 2026, Sartorius Stedim Biotech expanded its portfolio during the first half of 2026 with the Ambr 250 HT Cell Therapies Vessel. The single-use vessel is intended to support efficient process development, scalability from early development through commercial manufacturing, and structured process data generation for digital and AI-supported cell therapy workflows.
• In June 2026, WuXi Biologics announced completion of its first GMP production campaign at the MFG17 drug-substance facility in Shanghai. The facility uses multiple single-use bioreactors providing 9,000 liters of total manufacturing capacity and is designed to support approximately 80–100 batches annually. 
• In May 2026, Thermo Fisher Scientific introduced the Gibco™ CTS™ DynaXS Single Use Bioreactor as a cGMP-ready platform for scalable cell therapy manufacturing. The system is designed to support controlled cell expansion from process development through clinical production and commercialization, addressing manufacturing requirements across oncology, autoimmune diseases, and other emerging therapeutic applications.

Single Use Bioreactors Market Segmentation Insights

The single use bioreactors market report presents an in-depth analysis of the various single use bioreactor manufacturers, across different segments, as defined in the table below:

Single-Use Bioreactors Market: Market Segmentations

Market Segmentations	Details
Type of Bioreactor	Stirred Tank Bioreactor Wave Induced Bioreactor Other Bioreactors
Scale of Operation	Preclinical and Clinical Commercial
Type of Cell Culture	Mammalian Microbial Others
Type of Biologics Synthesized	Vaccine Monoclonal Antibody Recombinant Protein Stem Cell Cell Therapy Gene Therapy
End Users	Biopharmaceutical / Pharmaceutical Industries Academic / Research Institutes
Geographical Regions	North America Europe Asia-Pacific Middle East and North Africa (MENA) Latin America

Given the bioreactor manufacturers are continuously putting efforts into improving their product portfolio for addressing the challenges related to biomanufacturing by delivering innovative disposable bioreactors to the pharmaceutical industry, the demand for such solutions is likely to increase in the future.

Industry Experts on Single Use Bioreactors Market

Discussions with multiple stakeholders in this domain influenced the opinions and insights presented in this study. The market report includes detailed transcripts of interviews conducted with the following individuals:

• Founder and Chief Executive Officer, Canada based Small Company
• Manager of Bioprocessing, US based Mid-sized Company
• Quality and Products Manager, US based Small Company
• Chief Executive Officer, Denmark based Small Company
• Global Director of Sales Support, Denmark based Small Company

Single Use Bioreactors domain will mark a turning point in 2026. Jean-Marc Cappia (Head of Market Development Intensified Chromatography, Sartorius Stedim Biotech), states, “The main challenge for our industry is making more drugs available and affordable because millions of children are still dying of infectious diseases for which vaccines exist. Single-use technology and process intensification are ways of addressing these challenges. Introduction of single-use equipment will continue to grow because the era of large blockbusters is behind us.”

Single Use Bioreactors Market Share Insights

Market Share by Type of Bioreactor: Stirred Tank Bioreactors Holds the Largest Share in Single Use Bioreactors Industry

• The global single use bioreactors market is further divided into various sub-segments based on the type of bioreactor, such as stirred tank, wave-induced, and other bioreactors. Currently, the stirred tank bioreactors segment (~80%) dominates the market, and stands to grow at a relatively higher CAGR, during the forecast period.
• The higher market share results from the various benefits associated with stirred tank bioreactors, including scalability, efficient mixing capabilities, and their widespread adoption in biopharmaceutical production.
• Stirred tank bioreactors are also less likely to cause damage to the cell cultures, as these bioreactors possess optimal blade diameters and agitation speed.

Market Share by Scale of Operation: Preclinical and Clinical Market Opportunities

• The global single use bioreactor market is segmented into various types based on the scale of operation, such as preclinical and clinical, and commercial. The preclinical and clinical scale segment led the single use bioreactors market, capturing the largest revenue share of more than 60% in the current year.
• As single use systems do not require additional maintenance, thus are suitable and more feasible choice for pre-clinical and clinical operations.

Market Share by Type of Cell Culture: Mammalian Segment Holds the Largest Share

• This segment highlights the distribution of market for single use bioreactors across various types of cell cultures, such as mammalian, microbial and others. Presently, the mammalian segment dominates the market, holding a share of ~65%, and this trend is unlikely to change in the future as well. It is worth mentioning that over 80% of the disposable bioreactors are suitable for processing mammalian cell cultures.
• The market for microbial cell cultures will grow at a higher CAGR of 10% during the period 2026-2035. This is due to the advantages of microbial cell cultures in the production of smaller, less complex biologics such as antibody fragments and single-domain antibodies.

Market Share by Type of Biologics: Monoclonal Antibodies Segment Dominates Single Use Bioreactors Market

• The global market for single use bioreactors is further divided into various sub-segments based on the type of biologics synthesized, such as vaccines, monoclonal antibodies, recombinant proteins, stem cells, cell therapies and gene therapy. Currently, the monoclonal antibodies segment (~35%) dominates the market, and this trend is unlikely to change in the future as well.
• The market for cell therapies is likely to grow at a higher CAGR of 13% during the period 2026-2035. The wider application of cell therapies in treating a myriad of disease indications is likely to drive the growth of this sub-segment.

Market Share by Type of End Users: Biopharmaceutical / Pharmaceutical Industries Hold the Largest Single Use Bioreactors Market Share

• The market by end user is further divided into various sub-segments, such as biopharmaceutical / pharmaceutical industries, and academic / research institutes. Presently, the biopharmaceutical / pharmaceutical industries segment (~65%) dominates the market, and this trend is unlikely to change in the future as well.
• The higher market share of biopharmaceutical / pharmaceutical industries is due to their high adoption rates for production of biologics and flexible manufacturing needs.

Market Share by Geographical Regions: Asia-Pacific to Propel the Single Use Bioreactors Market Growth in the Coming Years

• This segment highlights the distribution of market size by region, including North America, Europe, Asia-Pacific, Middle East and North Africa and Latin America. According to our projections, North America is likely to capture the majority (>35%) of the market share.
• It is worth highlighting that the market in Asia-Pacific is likely to grow at a relatively higher CAGR (11%), during the forecast period. This is a result of the ongoing efforts of companies based in this region towards expanding their product portfolio for long-term growth and success.

Single Use Bioreactors Market: Report Deliverables

Report Deliverables	Details
Excel Data Packs (Complimentary)	Market Landscape Analysis Key Insights Company Competitiveness Analysis Partnerships and Collaborations Product Competitiveness Analysis Brand Positioning Analysis Patent Analysis Market Forecast and Opportunity Analysis
Key Single Use Bioreactor Manufacturers	Celartia Cell Culture Company Cellexus Cercell Cytiva Eppendorf Esco Bioengineering Getinge Merck Millipore PBS Biotech PerfuseCell ProlifeCell Sartorius AG Solaris Biotech Synthecon Thermo Fisher Scientific (Full list of 60+ companies captured is available in the report)
PowerPoint Presentation (Complimentary)	Available
Customization Scope	10% Free Customization

Single Use Bioreactors Market Major Takeaways

The “Single Use Bioreactors Market (4th Edition): Industry Trends and Global Forecasts, till 2035” report features an extensive study of the current market landscape, market size and future opportunities associated with this industry, for the given forecast period. The market research report highlights the efforts of single use bioreactor manufacturers engaged in this emerging and rapidly evolving segment of the bioprocessing industry.

Rising Interest in Disposable Bioreactors: Single Use Bioreactors vs Stainless Steel Bioreactors

The growing demand for quality products has encouraged biologic manufacturers to adopt single-use bioreactors, a more advanced and long-term solution. These disposable bioreactors are cost effective and have the capability to provide operational flexibility as compared to stainless steel bioreactors, thereby propelling the biopharmaceutical companies to adopt disposable bioreactors for bioprocessing.

Other advantages of single use bioreactors over conventional stainless steel bioreactors include ~50% reduction in total energy and water consumption and ~40% cost saving by elimination of cleaning and sterilization processes after every batch production.

Current Landscape of Single Use Bioreactors

The current single use bioreactors manufacturers landscape features the presence of over 60 industry stakeholders developing more than 260 single-use bioreactors. The market is highly fragmented with the presence of large, mid-sized and small companies. It is worth highlighting that constant evolution of disposable bioreactors is likely to support the development of novel and more efficacious biologics, in turn, contributing to the substantial growth of single use bioreactors market, during the forecast period.

Market Size Analysis: What is the Opportunity for the Disposable Stirred Tank Bioreactor for Vaccine Manufacturing?

The global single use bioreactors market size is likely to be worth $ 4.81 billion in 2026 and will reach $ 10.48 billion by 2035. In terms of the type of bioreactor, stirred tank bioreactors segment dominates the single use bioreactors market share. The single use stirred tank bioreactor segment captures 80% of the market share and it is likely to grow at a CAGR of 14% during the forecast period. Single use stirred tank bioreactors gained attention during the COVID-19 pandemic in their role to meet the global demand for COVID vaccines and streamlining the manufacturing process at widespread manufacturing facilities.

The broader application areas of single use bioreactors and their easy installation and handling, along with their high productivity and efficiency, are the primary drivers of this market. Further, single-use bioreactors require less space than conventional systems and offer cost effectiveness for companies, thus it is likely to significantly drive the adoption of these solutions in the future.

Regional Analysis: Which Region Holds the Largest Single Use Bioreactors Market Share?

North America: Looming US Tariff Will Drive the Demand for Single Use Bioreactors

Overall, the companies based in North America and Europe capture 75% share of the current market. Companies such as ABEC, Eppendorf, Merck Millipore, PBS Biotech and Thermo Fisher Scientific offer a wide range of single use bioreactors. These companies have in-house single use bioreactor portfolio, with different types of bioreactors, such as stirred tank bioreactor, wave / induced bioreactor and pneumatically mixed bioreactor. This is due to the presence of advanced biopharmaceutical industries, significant investments in biotechnology, robust research infrastructure, and strong regulatory support in developed regions.

Furthermore, the recent pressure from the Trump administration related to import tariffs is also driving the pharmaceutical and biotechnology companies to invest in manufacturing facilities in the US. A number of big pharmaceutical companies have already announced their investments in biologics manufacturing facilities in the US including Merck, AbbVie, Eli Lilly, Roche, Novartis and Johnson & Johnson. New facilities will drive the demand for single use bioreactors over the forecast period.

Asia-Pacific Region is Home to Several Large Biologic Contract Manufacturers

The market in Asia-Pacific is expected to grow at a relatively high CAGR (11%), during the forecast period till 2035. This is due to the establishment of several manufacturing facilities in Asia-Pacific region to meet the growing local demand for biologics from the consumers as well as the demand from small biopharmaceutical startups.

A number of manufacturing facilities are being set up in Asia Pacific region, to meet the growing local demand for biologics from the consumers. Moreover, a number of CMOs are setting up new facilities or announcing expansions in countries such as Singapore and Korea. WuXi Biologics is slated to open its 120,000 L capacity manufacturing facility at Tuas Biomedical Park, Singapore.

What are the Key Challenges of Single Use Bioreactors? Do the Benefits Overshadow the Environmental Impact from Plastic Waste?

One of the key challenges faced by single use bioreactor manufacturers is the reluctance of industry players to adopt these novel systems. This is due to the expenses that they are likely to incur while switching to new technology. Further, disposable bioreactors pose a reasonable risk of contamination from extractables and leachables, which can jeopardize the safety of drug products and well-being of the patient. It is worth highlighting that several disposable bioreactor manufacturers are striving to tackle these challenges through innovation in design and manufacturing methods.

The current inability of single use bioreactors to operate at volume greater than 6,000 L for large scale production, remains another pressing concern. Furthermore, with the growing focus on sustainability goals, the plastic waste generated through the use of single use bioreactors is concerning to the manufacturers.

Key Trends in Single Use Bioreactors Market

Rising Partnerships and Collaborations Amongst the Single Use Bioreactor Manufacturers to Foster Progress and Innovation in Expanding their Capabilities

Single use bioreactor manufacturers have forged several partnerships with other stakeholders to consolidate their presence in this field and enhance their capabilities and product portfolio to meet the growing demand for biotherapeutics. In fact, the partnership activity in this domain grew at a CAGR of ~15% over the past five years. Interestingly, most of the agreements were supply and technology integration agreements. The domain also witnessed a significant number of mergers and acquisitions during the past five years, indicating the growing interest of stakeholders in this industry.

Rising Demand and Adoption of Large Scale Disposable Bioreactors

It is worth mentioning that ABEC, Henan Lanphan, and Thermo Fisher Scientific are amongst the key players that have launched the largest single-use bioreactors with a capacity of more than 4,000 L. A number of CDMOs are adoptinghave shown positive interest in the adoption of these large-scale bioreactors. In a recent announcement, AGC Biologics announced its plans to install two 5,000 L DynaDrive SUBs from Thermo Fisher at its Yokohama, Japan facility which is slated to begin operations in 2026. In May 2026, 3PBIOVIAN, a Spanish CDMO, expanded its mammalian cell culture capacity by installing an additional 2,000 L single-use bioreactor to support the development and commercial manufacturing of recombinant proteins.

Technological Advancements to Fuel Innovation and Drive Efficiency

Stakeholders engaged in this industry are identifying new ways to enhance efficiency and reduce turnaround time. This has led to various technological advancements in this field, which include alerts / alarms, built-in system process control sensors, electronic process logs, remote monitoring features, touch screens, and advanced safety provisions, that have demonstrated an increase in efficiency and quality of the process.

The single use bioreactors market is witnessing the adoption of bioprocessing 4.0 solutions that leverage machine learning (ML) and artificial intelligence (AI) for real-time process monitoring. These advancements are likely to result into better yields, reduced waste, and development of higher quality biologics.

Single Use Bioreactors Market Report Coverage

The market report presents an in-depth analysis, highlighting the capabilities of various stakeholders in the single use bioreactors industry, across different geographies. Amongst other elements, the market report includes:

• An Infographic Executive Summary
• Market Landscape Analysis
• Key Insights
• Company Competitiveness Analysis
• Partnerships and Collaborations
• Product Competitiveness Analysis
• Brand Positioning Analysis
• Patent Analysis
• Company Profiles
• Market Forecast and Opportunity Analysis
• A Case Study on Bioprocess Controllers and Automation Systems

From the Author’s Desk

Author’s View on Single Use Bioreactors Market

Single-use bioreactors utilize disposable plastic bags for culturing cells, offering reduced contamination risks and lower operational costs compared to traditional stainless-steel systems. Key drivers of this market include the growing demand for biologics, regulatory emphasis on flexible manufacturing, and the need for faster production cycles with minimum cross contamination risks. Single use bioreactors are becoming a mainstay in the bioprocessing industry, with the manufacturers trying to plug the gaps in the market through launch of large-scale single use bioreactors. As the technology for recycling plastic waste develops, their adoption will witness a positive push.

About Authors

Lead Author: Akarshika Singh

Lead Reviewer: Dhriti Gulati

Chief Editor: Simriti Gupta

Glossary

• Bioprocessing 4.0: Bioprocessing 4.0, often referred to as the digital transformation of biomanufacturing, involves leveraging advanced technologies and interconnected systems to enhance bioprocesses.
• Stirred tank bioreactors: Stirred tank bioreactors are cylindrical vessels with an impeller to agitate and mix fluids, ensuring uniform conditions for biological processes like fermentation and cell culture.
• Wave-induced bioreactors: Wave-induced bioreactors, also known as wave bioreactors or wave-mixed bioreactors, are a type of bioreactor that uses the movement of waves to mix and aerate the culture medium.
• Biosensor: A biosensor is an analytical device, used for the detection of a chemical substance that combines a biological component with a physicochemical detector.