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3D Cell Cultures: Products, Technologies and Key Application Areas (2nd Edition), 2017-2030

Published: Sep 28, 2017
Pages: 339
Product Code: RA10090
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A number of research efforts in drug discovery are being directed towards the introduction of in vitro testing models that replicate the in vivo microenvironment and provide physiologically relevant insights. Cell culture monolayers or 2D cell cultures are known to harbor differences in morphology, growth rate, function, viability and the overall behavior, as compared to those in natural environment. However, it has been realized that 3D cell cultures facilitate cell interaction with the surrounding media in all the possible dimensions. Cells cultivated using 3D techniques provide an appropriate ecosystem for cells to grow and proliferate and, consequently generate more accurate results of the experiments conducted on them.

 

The 3D cell culture industry is currently characterized by presence of several scaffold-based and scaffold-free products and services, widely being used for the purpose of research across a variety of application areas. Examples of scaffold-based 3D culture products include solid scaffolds, hydrogels, ECM-coated plates and microcarriers. Products, such as hanging drop plates, ultra-low attachment surfaces, micropatterned plates and suspension culture systems (such as 3D bioreactors), are some of the important scaffold-free 3D technologies that are currently available. It is worth highlighting that despite the advantages that they offer, the adoption of 3D cell cultures is hindered by certain challenges. These cell culture systems are currently limited to small scale production of cells, thereby, restricting their use to research applications only. Moreover, 3D culture techniques still need to be optimized in order to ensure consistency of results generated across different scales of operation. Due to the aforementioned challenges, 2D cultures continue to be preferred over 3D culture systems; however, with increasing awareness of the advantages of 3D cultures, a significant proportion of researchers are anticipated to gradually transition towards 3D culture systems. 

 

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It is well-known that, of the several drug / therapy candidates undergoing clinical evaluation, very few make it to advanced stages and an even lesser number receive regulatory approval. One of the key reasons for the failure of therapeutic candidates in clinical trials is the use of conventional 2D cell culture systems in early research studies. It is important to reiterate that these 2D systems are severely limited in a number of aspects. For instance, only 50% of the cell surface is exposed to the culture media; as a result, the actual responses of cells to specific modulators / stimulants cannot be accurately understood. It is also worth noting that attrition rates of close to 95% have been reported for anti-cancer drug candidates as a result of inaccurate in vitro drug efficacy results and unforeseen toxicity issues that were not properly assessed due to the limitation of 2D culture models. The use of advanced 3D cell culture techniques in in vitro studies is seen to have the capability to overcome several such challenges, currently associated with 2D systems.

 

The ‘3D Cell Cultures: Products, Technologies and Key Application Areas (2nd Edition), 2017-2030’ report features an extensive study on the various scaffold-based and scaffold-free 3D culture systems. We identified over 80 hydrogel / ECM based products, 70 inserts / plates / other cultureware and 50 3D bioreactors that are widely being used for a variety of research applications across the globe. In addition, several kits, assays and tools are also available to carry out cytotoxicity assessments, transfections and cell viability testing. Amongst other elements, the report features:

  • An elaborate discussion on the methods used for fabrication of 3D scaffolds and matrices, highlighting the materials used, the process of fabrication, merits and demerits, and the applications of all of the methods.
  • An in-depth classification of 3D culture systems, which are categorized under scaffold-based systems (such as hydrogels / ECMs, solid scaffolds, micropatterned surfaces and microcarriers) and scaffold-free (such as hanging drop plates, suspension culture systems and organ-on-chips) 3D culture systems.
  • A review of the overall landscape of the 3D cell culture market with respect to scaffold-format (scaffold-based / scaffold-free), product type (Hydrogels / ECMs, 3D cultureware, 3D bioreactors), product sub-type (hydrogels / ECMs are further classified on the basis of source and 3D cultureware on the basis of solid scaffolds, suspension culture systems, microfluidic systems, ECM-coated plates, attachment resistant cell culture plates, micropatterned surfaces) and product availability across different regions of the world.
  • Comprehensive profiles of the key developers (with two or more unique bioreactors in their portfolio) of 3D bioreactors, featuring a brief company overview, description of the product, advantages, applications, collaborations related to the product, and a comprehensive future outlook. Additionally, the report includes profiles of companies with more than five unique 3D culture products (inserts or plates or hydrogels) in their portfolio and those that specialize in the field of organ-on-chips.
  • A social media analysis depicting the prevalent and emerging trends, and the popularity of 3D cell cultures on the social media platform, Twitter. The analysis was carried out using tweets posted on the platform from 2008 to 2017.
  • An insightful analysis, highlighting the applications of each of the 3D culture products mentioned in the market landscape. The applications have been categorized under [A] Cancer research, [B] Drug discovery and toxicity screening, [C] Stem cell research, [D] Tissue engineering / regenerative medicine. Additionally, the section represents the distribution of each of the product segments across the aforementioned applications, highlighting the relevance of different types of products in biomedical research.

 

One of the key objectives of the report was to estimate the future size of the global 3D cell culture market. We adopted a top-down approach to evaluate the likely success and the growth of the market over the next 10-15 years. The insights generated on the future opportunity are segmented on the basis of applications areas, key geographies (the US, EU, Asia and the rest of the world), product type, scaffold format (scaffold-based versus scaffold-free) and the end use (research versus therapeutics). In order to account for the uncertainties associated with some of the key parameters and to add robustness to our model, we have provided three market forecast scenarios for the period 2017-2030, namely conservative, base and optimistic scenarios, which represent three different tracks of the industry’s evolution.

 

The research, analysis and insights presented in this report are backed by a deep understanding of key insights gathered from both secondary and primary research. The report presents details of the conversations with (in alphabetical order of company name) Scott Brush (VP Sales and Marketing, BRTI Life Sciences), Jens Kelm (CSO, InSphero), Darlene Thieken (Project Manager, Nanofiber Solutions), Colin Sanctuary (Co-Founder and CEO, QGel), Bill Anderson (President / CEO, Synthecon), Anonymous (President and CEO, US based start-up), Anonymous (VP Technical, Business Operations & Co-Founder, US based company).

 

 

Example Highlights

  1. Over 200 3D cell culture products are either commercially available or are under development; of these, ~60% use scaffold based while ~40% use scaffold free formats. Some products can be used as both scaffold based and scaffold free formats. Of the total number of 3D cell culture products, 40% are hydrogels / ECMs and 34% are 3D cultureware products. In addition to the aforementioned products, the 3D cell culture market includes several 3D bioreactors, which have emerged as important scaffold free systems to carry out large scale production. 
  2. The market is characterized by the presence of nearly 125 players; in addition to industry stalwarts, the landscape features participation of several small-sized and mid-sized firms. Examples of small-sized companies that offer 3D culture products include (in alphabetical order) 3D BioMatrix, Celartia, Cellec Biotek, EBERS, Global Cell Solutions, Nanofiber Solutions, Nano3D Biosciences, PBS Biotech and RealBio Technology. Some of the mid-sized players that are active in this area include (in alphabetical order) 4titude®, Koken, MatTek Corporation, STEMCELL Technologies and TAP Biosystems. Examples of the established players include (in alphabetical order) Corning Life Sciences, EMD Millipore, GE Healthcare, Sigma-Aldrich and Thermo Fisher Scientific.
  3. An analysis on the social media platform, Twitter, reveals an increasing volume of tweets related to the 3D cell cultures; between 2008 and 2016, a CAGR of 57% was registered in the number of tweets. In the given time period, over 4000 relevant tweets were recorded; this clearly indicates an upsurge in the popularity of the 3D cell culture approaches.
  4. Over 90% of the overall 3D cell culture market is focused on research. However, as the challenges (such as lack of awareness, constraints in scalability and inconsistencies in system optimization) associated with the application of these robust culture systems are addressed, these systems are expected to be extensively used for the development, manufacturing and characterization of pharmacological interventions.
  5. Our outlook is highly promising as we anticipate the use of 3D cell culture systems across different application areas over the coming decade. In fact, we predict the market to grow at an annualized rate of over 20% till 2030. From a regional perspective, North America (specifically the US) is likely to maintain its domination in the future.
  6. Cancer research and drug discovery, with over 50% share, currently account for a significant portion of the market. As the research pace heightens, the use of 3D cell cultures in stem cell research and tissue engineering / regenerative medicine, currently representing a sizeable share, is also likely to expand aggressively.

 

 

Research Methodology

The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Where possible, the available data has been checked for accuracy from multiple sources of information.

 

The secondary sources of information include

  • Annual reports
  • Investor presentations
  • SEC filings
  • Industry databases
  • News releases from company websites
  • Government policy documents
  • Industry analysts’ views

 

While the focus has been on forecasting the market over the coming 10-15 years, the report also provides our independent view on various technological and non-commercial trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.

 

 

Chapter Outlines

Chapter 2 presents an executive summary of the report. It offers a high-level view on where the 3D cell cultures market is headed in the mid to long term.

 

Chapter 3 provides a general introduction to 3D culture systems. In this section, we have briefly discussed the different types of cell cultures, the various methods of cell culturing and their application areas. The chapter features a comparative analysis of 2D and 3D cultures, and highlights the current need and advantages of 3D culture systems.

 

Chapter 4 gives an overview of the classification of 3D culture systems. It highlights the different 3D culture technologies, classified under scaffold-based and scaffold-free systems. It also highlights, in detail, the underlying concepts, advantages and disadvantages of each sub-category of 3D systems.

 

Chapter 5 presents summaries of the different techniques that are utilized to fabricate various 3D scaffolds and matrices. It provides information on the working principle, and merits and demerits associated with these methods. It also presents the key takeaways from various research studies that were carried out on matrices fabricated using the aforementioned methods.

 

Chapter 6 provides comprehensive lists of the different 3D culture systems that are available in the market or are under development. The section also presents analyses of the products on the basis of scaffold type, product type (3D hydrogels and ECMs / 3D cultureware / 3D bioreactors) and product sub-type. In addition, the chapter provides information on the geographical presence of the developers of these 3D culture systems and details on the companies that offer 3D culture related services and associated consumables.

 

Chapter 7 presents a detailed overview on the most popular application areas, which include cancer research, drug discovery and toxicity screening, stem cell research and tissue engineering / regenerative medicine. It features an elaborate analysis, highlighting the application area(s) for all the products mentioned in the market landscape (Chapter 6). Additionally, the section features an illustrative representation of the product type(s) that are most widely used for a particular application.

 

Chapter 8 provides insights on the popularity of 3D cell cultures on the social media platform, Twitter. The section highlights the yearly distribution of tweets posted on the platform in the time period 2008-2017, and the most significant events responsible for increase / decrease in the volume of tweets each year, during the above-mentioned time period. Additionally, the chapter showcases the most talked about 3D culture products and application areas on social media.

 

Chapter 9 provides detailed profiles of the players with over five unique products in their 3D culture portfolio (hydrogels / ECMs and 3D cultureware). Each profile includes information on the developer, its product portfolio, recent collaborations and a discussion on the future outlook of the company. Additionally, the chapter includes profiles of prominent developers of organ-on-chips.

 

Chapter 10 presents detailed profiles of key players with more than two unique 3D bioreactors in their portfolio. Each profile includes a brief overview of the developer, information on the product portfolio and a discussion on the future outlook of the company.

 

Chapter 11 presents a comprehensive market forecast, highlighting the future potential of the market till 2030. The chapter presents a detailed market segmentation on the basis of product type (3D bioreactors, hydrogels / ECM, solid scaffolds, microfluidic plates, suspension culture systems), scaffold type (scaffold-based versus scaffold-free) and end use (research versus therapeutics) that are likely to contribute to the market in the coming decade. Additionally, the section highlights the contribution of different geographies (the North America, EU, Asia and rest of the world) in the 3D culture market.

 

Chapter 12 presents insights from the survey conducted for this study. We invited close to 100 stakeholders involved in the development of 3D cell culture systems. The participants, who were primarily Founder / CXO / Senior Management level representatives of their respective companies, helped us develop a deeper understanding on the nature of their services and the associated commercial potential.

 

Chapter 13 summarizes the overall report. The chapter provides a list of the key takeaways and presents our independent opinion on the 3D cell cultures market, based on the research and analysis described in the previous chapters.

 

Chapter 14 is a collection of interview transcripts of the discussions held with key stakeholders in this market. In this chapter, we have presented the details of our conversations with (in alphabetical order of company name) Scott Brush (VP Sales and Marketing, BRTI Life Sciences), Jens Kelm (CSO, InSphero), Darlene Thieken (Project Manager, Nanofiber Solutions), Colin Sanctuary (Co-Founder and CEO, QGel), Bill Anderson (President / CEO, Synthecon), Anonymous (President and CEO, US based start-up), Anonymous (VP Technical, Business Operations & Co-Founder, US based company).

 

Chapter 15 is an appendix, which provides tabulated data and numbers for all the figures included in the report.

 

Chapter 16 is an appendix, which provides the list of companies and organizations mentioned in the report.

 

 
1 PREFACE
1.1.  Scope of the Report
1.2.  Research Methodology
1.3.  Chapter Outlines
 
2 EXECUTIVE SUMMARY
 
3 INTRODUCTION
3.1. Chapter Overview
3.2. Classification of Cell Cultures
3.2.1. Primary Cell Cultures
3.2.2. Cell Lines
3.3. Morphology of Cells in Culture
3.4. Transition from 2D to 3D Cell Culture
3.5. The Concept of 3D Cell Culture
3.5.1. Components of the Extra Cellular Matrix (ECM)
3.5.2. In Vitro Cell Culture
3.5.3. Selection of Culture Format
3.6. Cell Cultures: Establishment and Maintenance
3.6.1. Isolating Cells from Tissues
3.6.2. Maintaining Cells in Culture
3.6.3. Sub-Culturing
3.6.4. Cryogenic Storage
3.6.5. Cross-Contamination Concerns
3.7. The Need for 3D Cell Culture Systems
3.7.1. Model Systems
3.7.2. Drug Discovery and Preclinical Research
3.7.3. Cancer Research
3.7.4. Virology Research
3.7.5. Genetic Engineering and Gene Therapy Research
3.8. Cell Culturing: Basic Requirements
3.8.1. The Cell Culture Facility and Safety Guidelines
3.8.2. Avoiding Contamination
3.8.3. Cell Culture Health and Optimal Conditions
3.9. 3D Cell Culture: Advantages and Limitations
3.10. Future Landscape of 3D Cell Culture
 
4 CLASSIFICATION OF 3D CELL CULTURE SYSTEMS
4.1 3D Cell Culture Classification: An Overview
4.2. Scaffold Based 3D Cell Cultures
4.2.1. Hydrogels / Extra Cellular Matrix (ECM) Analogs
4.2.2. Solid Scaffolds
4.2.3. Micropatterned Surfaces
4.2.4. Microcarriers
4.3. Scaffold Free 3D Cell Cultures
4.3.1. Attachment Resistant Surfaces
4.3.2. Suspension Culture Systems
4.3.2.1. Hanging Drop Plates
4.3.2.2. 3D Bioreactors
4.3.2.3. Magnetic Levitation and 3D Bioprinting
4.3.3. Microfluidic Surfaces and Organs-on-Chips
4.4. Organoids
 
5 METHODS USED FOR FABRICATION OF 3D MATRICES AND SCAFFOLDS
5.1. Chapter Overview
5.2. Methods for Fabricating Porous Scaffolds
5.2.1. Particulate Leaching
5.2.2. Solvent Casting
5.2.3. Emulsion Templating
5.2.4. Gas Foaming
5.2.5. Melt Molding
5.2.6. Microsphere Sintering
5.3. Methods for Fabricating Fibrous Scaffolds
5.3.1. Electrospinning
5.3.2. Phase Separation
5.3.3. Self-Assembly
5.3.4. Fiber Mesh and Fiber Bonding
5.4. Methods for Fabricating Hydrogels
5.4.1. Gelation
5.4.2. Solvent Casting and Particulate Leaching
5.4.3. Gas Foaming
5.4.4. Freeze Drying
5.4.5. Co-Polymerization / Crosslinking
5.4.6. Microfluidics
5.5. Methods for Fabricating Custom Scaffolds
5.5.1. Stereo-lithography
5.5.2. 3D Bioprinting and Selective Laser Sintering (SLS)
5.5.3. Fused Deposition Modeling
5.5.4. Membrane Lamination
5.5.5. Rapid Prototyping / Solid Free-Form (SFF) Technique
5.6. Methods for Fabricating Microspheres
5.6.1. Solvent Evaporation
5.6.2. Single and Double Emulsification
5.6.3. Particle Aggregation
5.7. Methods for Fabricating Native Scaffolds
5.7.1. Decellularization
 
6 MARKET OVERVIEW
6.1. Chapter Overview
6.2. 3D Cell Culture Products: List of Hydrogels / Extracellular Matrices (ECMs), Cultureware and Bioreactors
6.2.1. 3D Cell Culture Products: Distribution by Type
6.2.2. 3D Cell Culture Products: Distribution by Scaffold Format
6.2.3. 3D Cell Culture Products: Distribution by Hydrogels / ECMs
6.2.4. 3D Cell Culture Products: Distribution by Cultureware
6.2.5. 3D Cell Culture Products: Most Active Players
6.2.6. 3D Cell Culture Products: Geographical Landscape of Developers
6.3. 3D Cell Culture Products: Assay Kits, Reagents and Services
 
7 3D CELL CULTURE: KEY APPLICATION AREAS
7.1. Chapter Overview
7.2. 3D Cell Culture Systems in Cancer Research
7.2.1. Reasons to Adopt 3D Cell Culture Systems in Cancer Research
7.2.2. Improving Cancer Drug Screening with 3D Cell Culture Systems
7.3. 3D Cell Culture Systems in Drug Discovery and Toxicity Screening
7.3.1. Drug Development Studies
7.3.2. Toxicity Screening
7.4. 3D Cell Culture Systems in Stem Cell Research
7.4.1. Potential of 3D Cell Culture Systems in Stem Cell Differentiation
7.4.2. In Vitro 3D Microenvironment to Induce Embryoid Body Formation
7.5. 3D Cell Culture Systems in Regenerative Medicine and Tissue Engineering
7. 6. 3D Cell Culture Systems: Analyses on Key Application Areas
7.6.1. 3D Cell Culture Products: Distribution by Applications and Types
7.6.1.1. Hydrogels / ECMs: Distribution by Applications
7.6.1.2. 3D Cultureware: Distribution by Applications
7.6.1.3. 3D Bioreactors: Distribution by Applications
 
8 EMERGING TRENDS IN 3D CELL CULTURE ON SOCIAL MEDIA
8.1. Chapter Overview
8.2. 3D Cell Culture: Trends on Twitter
8.2.1. 3D Cell Culture: Yearly Distribution of Tweets
8.2.2. 3D Cell Culture: Word Cloud Analysis
8.2.3. 3D Cell Culture: Popular Product Types on Twitter, 2008-2017
8.2.4. 3D Cell Culture: Popular Product Sub-types on Twitter, 2008-2017
8.2.5. 3D Cell Culture: Popular Applications on Twitter, 2008-2017
 
9 3D CELL CULTURE PRODUCTS: KEY PLAYERS
9.1. Chapter Overview
9.2. Developers of 3D Cultureware and ECMs / Hydrogels
9.2.1. 3D Biotek
9.2.1.1. Developer Overview
9.2.1.2. Product Portfolio
9.2.1.3. Future Outlook
 
9.2.2. Advanced BioMatrix
9.2.2.1. Developer Overview
9.2.2.2. Product Portfolio
9.2.2.3. Future Outlook
9.2.3. Alphabioregen
9.2.3.1. Developer Overview
9.2.3.2. Product Portfolio
9.2.3.3. Future Outlook
 
9.2.4. Corning Life Sciences
9.2.4.1. Company Overview
9.2.4.2. Product Portfolio
9.2.4.3. Future Outlook
 
9.2.5. ReproCELL
9.2.5.1. Developer Overview
9.2.5.2. Product Portfolio
9.2.5.3. Future Outlook
 
9.3. Developers of Organs-on-Chips
9.3.1. CN Bio Innovations
9.3.1.1. Company Overview
9.3.1.2. Product Portfolio
 
9.3.2. Emulate
9.3.2.1. Company Overview
9.3.2.2. Product Portfolio
 
9.3.3. InSphero
9.3.3.1. Company Overview
9.3.3.2. Product Portfolio
 
9.3.4. MIMETAS
9.3.4.1. Company Overview
9.3.4.2. Product Portfolio
 
9.3.5. Nortis
9.3.5.1. Company Overview
9.3.5.2. Product Portfolio
9.3.6. TissUse
9.3.6.1. Company Overview
9.3.6.2. Product Portfolio
 
10 3D CULTURE BIOREACTORS: KEY PLAYERS
10.1. Chapter Overview
10.2.1 Celartia
10.2.1.1. Developer Overview
10.2.1.2. Product Portfolio
10.2.1.3. Future Outlook
 
10.2.2. Cell Culture Company
10.2.2.1. Developer Overview
10.2.2.2. Product Portfolio
10.2.2.3. Future Outlook
 
10.2.3. CESCO BioProducts
10.2.3.1. Developer Overview
10.2.3.2. Product Portfolio
10.2.3.3. Future Outlook
 
10.2.4. China Regenerative Medicine International
10.2.4.1. Company Overview
10.2.4.2. Product Portfolio
10.2.4.3. Future Outlook
 
10.2.5. EBERS
10.2.5.1. Developer Overview
10.2.5.2. Product Portfolio
10.2.5.3. Future Outlook
 
10.2.6. PBS Biotech
10.2.6.1. Developer Overview
10.2.6.2. Product Portfolio
10.2.6.3. Future Outlook
 
10.2.7. Synthecon
10.2.7.1. Developer Overview
10.2.7.2. Product Portfolio
10.2.7.3. Future Outlook
 
11 MARKET FORECAST
11.1. Chapter Overview
11.2. Key Assumptions and Methodology
11.3. 3D Cell Culture Market Forecast, 2017-2030
11.3.1. 3D Cell Culture Market Forecast: Distribution by Application
11.3.2. 3D Cell Culture Market Forecast: Distribution by Scaffold Format
11.3.3. 3D Cell Culture Market Forecast: Distribution by Product Type
11.3.4. 3D Cell Culture Market Forecast: Distribution by Geography
11.3.5. 3D Cell Culture Market Forecast: Distribution by End Use
 
12 SURVEY ANALYSIS
12.1. Chapter Overview
12.2. Overview of Respondents
12.3. Focus Area of the Company
12.4. Category of Lead Product(s)
12.5. Nature of Matrices
12.6. Development Status of Lead Product(s)
12.7. Sources of 3D Cultured Cells
12.8. Applications of 3D Cell Culture Products
12.9. Likely Market Size
  
13 CONCLUSION
 13.1. 3D Cell Cultures, With Inherent Advantages over 2D Cell Cultures, are Gradually Gaining Attention in the Research Industry
 13.2. Most 3D Cell Cultures Require a Supporting Scaffold for Growth and Propagation; However, Scaffold Free Techniques are Available as Well
                             
 13.3. Such Advanced Culture Systems have Found Use in a Myriad of Application Areas
     
 13.4. Despite the Ongoing Innovation, 3D Cell Cultures are Yet to Unveil Potential in Mainstream Therapeutics
 13.5. Post Mitigation of Associated Challenges, The Market is Likely to Witness a Higher Adoption
13.6. Overall, the 3D Cell Culture Market is Likely to Emerge as a Multi-Billion Dollar Market in the Long Term
 
14 INTERVIEW TRANSCRIPTS
 14.1. Chapter Overview
 14.2. Bill Anderson, President and Chief Executive Officer, Synthecon
 14.3. Colin Sanctuary, Co-Founder and Chief Executive Officer, QGel
 14.4. Darlene Thieken, Senior Management, Nanofiber Solutions
 14.5. Jens Kelm, Chief Scientific Officer, InSphero
 14.6. Scott Brush, VP Sales and Marketing, BRTI Life Sciences
 14.7. Anonymous, President and Chief Executive Officer, Leading Company in 3D Cell Culture Domain
 14.8. Anonymous, VP-Technical, Business Operations & Co-Founder, Leading Company in 3D Cell Culture Domain
 
15 APPENDIX: TABULATED DATA
  
16 APPENDIX: LIST OF COMPANIES AND ORGANIZATIONS
 
Figure 3.1 Classifications of Cell Cultures
 
Figure 3.2 Types of Cell Culture Systems
 
Figure 3.3 Key Components of Extra Cellular Matrix (ECM)
 
Figure 3.4 Factors Influencing the Choice of 3D Cell Culture Systems
 
Figure 3.5 Methods of Cell Isolation from Tissues
 
Figure 3.6 Methods of Cryogenic Storage
 
Figure 3.7 Applications of Cell Culturing
 
Figure 3.8 3D Spheroids Generated via 3D Cell Culture Systems
 
Figure 3.9 Cell Culture: Biosafety Levels
 
Figure 4.1 Classification of 3D Cell Culture Systems
 
Figure 4.2 Natural Components of Extracellular Matrix (ECM) for Fabrication of Scaffolds
 
Figure 4.3 Hydrogels: Advantages and Disadvantages
 
Figure 4.4 Microcarriers: Advantages
 
Figure 4.5 Techniques Used for Formation of Spheroids
 
Figure 4.6 Spinner Flask and Rotating Wall Bioreactors: Device Structure
 
Figure 6.1 3D Cell Culture Products: Distribution by Type
 
Figure 6.2 3D Cell Culture Products: Distribution by Scaffold Format
 
Figure 6.3 3D Cell Culture Products: Distribution by Hydrogels / ECMs
 
Figure 6.4 3D Cell Culture Products: Distribution by Cultureware
 
Figure 6.5 3D Cell Culture Products: Most Active Players
 
Figure 6.6 3D Cell Culture Products: Geographical Landscape of Developers
 
Figure 7.1 3D Cell Culture: Key Applications
 
Figure 7.2 Reasons to Adopt 3D Cell Culture Systems in Cancer Research
 
Figure 7.3 3D Cell Culture Systems in Drug Discovery and Toxicity Screening
 
Figure 7.4 3D Cell Culture: Effect on Stem Cell Differentiation
 
Figure 7.5 Methods for Embryoid Body Formation
 
Figure 7.6 Tissue Engineering: Top-Down and Bottom-Up Approach
 
Figure 7.7 3D Cell Culture Products: Distribution by Applications and Types
 
Figure 7.8 Hydrogels / ECMs: Distribution by Applications and Sub-types
 
Figure 7.9 3D Cultureware: Distribution by Applications and Sub-types
 
Figure 7.10 3D Bioreactors: Distribution by Applications 
 
Figure 8.1 3D Cell Culture: Yearly Distribution of Tweets, 2008-2017
 
Figure 8.2 3D Cell Culture: Historical Trends by Twitter Volume, 2008-2017
 
Figure 8.3 3D Cell Culture: Popular Keywords on Twitter, 2008-2017
 
Figure 8.4 3D Cell Culture: Popular Product Types on Twitter, 2008-2017
 
Figure 8.5 3D Cell Culture: Popular Product Sub-types on Twitter, 2008-2017
 
Figure 8.6 3D Cell Culture: Popular Organ-on-Chip Models on Twitter, 2008-2017
 
Figure 8.7 3D Cell Culture: Popular Applications on Twitter, 2008-2017
 
Figure 9.1 ReproCELL: Types of Alvetex® 3D Cell Culture Products
 
Figure 10.1 PetakaG3™ Bioreactors: Design Description
 
Figure 10.2 Cell Culture Company Perfusion Bioreactors: Features
 
Figure 10.3 MagDrive and AirDrive Mechanisms
 
Figure 10.4 Rotary Cell Culture System (RCCS): Advantages
 
Figure 11.1 3D Cell Culture Market (2017-2030): Base Scenario (USD Billion)
 
Figure 11.2 3D Cell Culture Market (2017-2030): Distribution by Application (USD Billion)
 
Figure 11.3 3D Cell Culture Market: Share by Application, 2017, 2030 (%) 
 
Figure 11.4 3D Cell Culture Market: Share by Scaffold Format, 2017 (USD Billion)
 
Figure 11.5 3D Cell Culture Market: Share by Product Type, 2017 (%)
 
Figure 11.6 3D Cell Culture Market: Share by Geography, 2017, 2030 (%)
 
Figure 11.7 3D Cell Culture Market: Share by End Use, 2017, 2030 (%)
 
Figure 11.8 3D Cell Culture Market: Leading Players, 2017 (%)
 
Figure 12.1 Survey Analysis: Distribution by Type of Company
 
Figure 12.2 Survey Analysis: Distribution by Location of Respondents
 
Figure 12.3 Survey Analysis: Distribution by Seniority Level of Respondents
 
Figure 12.4 Survey Analysis: Distribution by Focus Area of the Company
 
Figure 12.5 Survey Analysis: Category of Lead Product(s)
 
Figure 12.6 Survey Analysis: Nature of Matrices
 
Figure 12.7 Survey Analysis: Status of Development of Lead Product(s)
 
Figure 12.8 Survey Analysis: Source of 3D Cultured Cells
 
Figure 12.9 Survey Analysis: Distribution by Application of 3D Cell Culture Products
 
Figure 12.10 Survey Analysis: Distribution by Likely Size of 3D Cell Culture Market
 
Figure 13.1 Overall 3D Cell Culture Market: Conservative, Base and Optimistic Scenarios, 2017-2030 (USD Billion)
 
Table 3.1 Morphology of Cells in a Culture
 
Table 3.2 Differences between 2D and 3D Cell Cultures
 
Table 3.3 Features of 3D Spheroids Generated via 3D Cell Culture Systems
 
Table 4.1 Scaffold Based and Scaffold Free Systems: Advantages and Disadvantages
 
Table 4.2 Natural and Synthetic Scaffolds: Advantages and Disadvantages
 
Table 4.3 Natural and Synthetic Hydrogels: Advantages and Disadvantages
 
Table 4.4 Cell Cultures Used in Magnetic Levitation
 
Table 4.6 Organoids: Origin and Culture Techniques
 
Table 5.1 Methods for Fabrication of Porous Scaffolds: Merits and Demerits
 
Table 5.2 3D Cell Culture Studies Using Porous Scaffolds
 
Table 5.3 Methods for Fabrication of Fibrous Scaffolds
 
Table 5.4 Methods for Fabrication of Fibrous Scaffolds: Merits and Demerits
 
Table 5.5 3D Cell Culture Studies Using Fibrous Scaffolds
 
Table 5.6 Methods for Fabrication of Hydrogels: Merits and Demerits
 
Table 5.7 3D Cell Culture Studies Using Hydrogels
 
Table 5.8 Fabrication of Custom Scaffolds: Merits and Demerits
 
Table 5.9 3D Cell Culture Studies Using Custom Scaffolds
 
Table 5.10 Fabrication of Microspheres: Merits and Demerits
 
Table 5.11 3D Cell Culture Studies Using Microspheres
 
Table 5.12 3D Cell Culture Studies Using Native Scaffolds
 
Table 6.1 3D Cell Culture Products: List of Hydrogels / ECM
 
Table 6.2 3D Cell Culture Products: List of Cultureware
 
Table 6.3 3D Cell Culture Products: List of Bioreactors
 
Table 6.4 3D Cell Culture Products: List of Assay Kits and Reagents
 
Table 6.5 3D Cell Culture Products: List of Services
 
Table 7.1 3D Cell Culture Products: Applications of Hydrogels / Extra Cellular Matrices (ECMs)
 
 
Table 7.2 3D Cell Culture Products: Applications of 3D Cultureware
 
Table 7.3 3D Cell Culture Products: Applications of 3D Bioreactors
 
Table 7.4 Hydrogels / ECM: Applications of Sub-types
 
Table 7.5 3D Cultureware: Applications of Sub-types
 
Table 7.6 3D Bioreactors: Applications
 
Table 9.1 3D Cell Cultureware and ECM: List of Players Profiled
 
Table 9.2 3D Biotek: Specifications of 3D Insert™-PS
 
Table 9.3 3D Biotek: Specifications of 3D Insert™-PCL
 
Table 9.4 Advanced BioMatrix: Specifications of PureCol® Collagen Coated T-25 Flasks
 
Table 9.5 Advanced BioMatrix: Specifications of PureCol® Collagen Coated Well Plates
 
Table 9.6 Advanced BioMatrix: Specifications of PureCol® Collagen Coated Dishes
 
Table 9.7 Advanced BioMatrix: Specifications of AlignCol®
 
Table 9.8 Advanced BioMatrix: Specifications of FibriCol®
 
Table 9.9 Advanced BioMatrix: Specifications of FlexiCol®
 
Table 9.10 Advanced BioMatrix: Specifications of Nutragen®
 
Table 9.11 Advanced BioMatrix: Specifications of PureCol®
 
Table 9.12 Advanced BioMatrix: Specifications of RatCol® Rat Tail Collagen I
 
Table 9.13 Advanced BioMatrix: Specifications of SphereCol®
 
Table 9.14 Advanced BioMatrix: Specifications of SpongeCol®
 
Table 9.15 Advanced BioMatrix: Specifications of TeloCol®
 
Table 9.16 Advanced BioMatrix: Specifications of VitroCol®
 
Table 9.17 Alphabioregen: Specifications of Hydrogel Coated Plates
 
Table 9.18 Alphabioregen: Specifications of Collagen Coated Plates
 
Table 9.19 Alphabioregen: Specifications of Matrix Coated Plates
 
Table 9.20 Alphabioregen: Specifications of Poly-L-Lysine Coated Plates
 
Table 9.21 Alphabioregen: Specifications of AlphaBioGel Products
 
Table 9.22 Alphabioregen: Specifications of Collagel Hydrogel Products
 
Table 9.23 Corning Life Sciences: Specifications of Corning® BioCoat™ Cultureware
 
Table 9.24 Corning Life Sciences: Specifications of Corning® CellBIND® Surface
 
Table 9.25 Corning Life Sciences: Specifications of Corning® Osteo Assay Surface Cultureware
 
Table 9.26 Corning Life Sciences: Specifications of Corning® Primaria™ Surface
 
Table 9.27 Corning Life Sciences: Specifications of Corning® PureCoat™ Cultureware
 
Table 9.28 Corning Life Sciences: Specifications of Corning® Spheroid Microplates
 
Table 9.29 Corning Life Sciences: Specifications of Permeable Supports
 
Table 9.30 Corning Life Sciences: Specifications of Corning® Collagen Products
 
Table 9.31 Corning Life Sciences: Specifications of Corning® Laminin Products
 
Table 9.32 Corning Life Sciences: Specifications of Corning® Matrigel Matrices
 
Table 9.33 Corning Life Sciences: Specifications of Other Extra Cellular Matrix Based Products
 
Table 9.34 ReproCELL: Specifications of Alvetex® Scaffold Multiwell Plate Formats
 
Table 9.35 ReproCELL: Specifications of Alvetex® Scaffold / Strata Well Insert
 
Table 9.36 ReproCELL: Specifications of Alvetex® Tools
 
Table 9.37 ReproCELL: Specifications of EZSPHERE® Products
 
Table 9.38 ReproCELL: Formats of EZSPHERE® Products
 
Table 9.39 ReproCELL: Specifications of Atelocollagen and Collagen Products
 
Table 10.1 3D Cell Culture Bioreactors: Companies Profiled
 
Table 10.2 Celartia: Features of PetakaG3™ Bioreactors
 
Table 10.3 Celartia: Specifications of PetakaG3™ ET Bioreactors
 
Table 10.4 Celartia: Specifications of PetakaG3™ HOT Bioreactors
 
Table 10.5 Cell Culture Company: Specifications of AutovaxID Bioreactor
 
Table 10.6 Cell Culture Company: Specifications of Maximizer Bioreactor
 
Table 10.7 Cell Culture Company: Specifications of MicroBrx Bioreactor
 
Table 10.8 Cell Culture Company: Specifications of Primer Bioreactor
 
Table 10.9 Cell Culture Company: Specifications of Xcellerator Bioreactor
 
Table 10.10 CESCO BioProducts: Specifications of BelloCell® Bioreactor
 
Table 10.11 EBERS: Specifications of TEB500 Series Bioreactor
 
Table 10.12 EBERS: Specifications of TEB1000 Series Bioreactor
 
Table 10.13 EBERS: Specifications of TC-3F Load Bioreactor
 
Table 10.14 PBS Biotech: Features of PBS Bioreactor Series with Dual Mechanism
 
Table 10.15 PBS Biotech: PBS MINI (PBS 0.1Mag / PBS 0.5Mag) Bioreactor
 
Table 10.16 PBS Biotech: Specifications of PBS 3 (PBS 3Air / PBS 3Mag) Bioreactor
 
Table 10.17 PBS Biotech: Specifications of PBS 15 (PBS 15Air / PBS 15Mag) Bioreactor
 
Table 10.18 PBS Biotech: Specifications of PBS 80 (PBS 80Air / PBS 80Mag) Bioreactor
 
Table 10.19 PBS Biotech: Specifications of PBS 500 Bioreactor
 
Table 10.20 Synthecon: Specifications of Autoclavable Bioreactors (RCCS-1)
 
Table 10.21 Synthecon: Specifications of Autoclavable Bioreactors (RCCS-4H / RCCS-4HD)
 
Table 10.22 Synthecon: Specifications of Perfusion Bioreactors (RCCMax / RCCMax Dual)
 
Table 10.23 Synthecon: Specifications of Single Use / Disposable Bioreactors (RCCS-D / RCCS-2D)
 
Table 10.24 Synthecon: Specifications of Single Use / Disposable Bioreactors (RCCS-4D / RCCS-4DQ)
 
Table 10.25 Synthecon: Specifications of Stem Cell Bioreactor (RCCS-1SC / RCCS-2SC)
 
Table 10.26 Synthecon: Specifications of Stem Cell Bioreactor (RCCS-4SC / RCCS- 4SCQ)
 
Table 12.1 Survey Response: Overview of the Participating Companies
 
Table 12.2 Survey Response: Overview of Respondents
 
Table 12.3 Survey Response: Focus Area of the Company
 
Table 12.4 Survey Response: Category of Lead Product(s)
 
Table 12.5 Survey Response: Nature of Matrices
 
Table 12.6 Survey Response: Development Status of Lead Product(s)
 
Table 12.7 Survey Response: Source of 3D Cultured Cells
 
Table 12.8 Survey Response: Applications of 3D Cell Culture Products
 
Table 12.9 Survey Response: Likely Size of 3D Cell Culture Market
 
Table 15.1 3D Cell Culture Products: Distribution by Type
 
Table 15.2 3D Cell Culture Products: Distribution by Scaffold Format
 
Table 15.3 3D Cell Culture Products: Distribution by Hydrogels / ECMs
 
Table 15.4 3D Cell Culture Products: Distribution by Cultureware
 
Table 15.5 3D Cell Culture Products: Most Active Players
 
Table 15.6 3D Cell Culture Products: Distribution by Applications and Types
 
Table 15.7 3D Cell Culture: Popular Product Types on Twitter, 2008-2017
 
Table 15.8 3D Cell Culture: Popular Organ-on-Chip Models on Twitter, 2008-2017
 
Table 15.9 3D Cell Culture Market (2017-2030): Base Scenario (USD Billion)
 
Table 15.10 3D Cell Culture Market (2017-2030): Optimistic Scenario (USD Billion)
 
Table 15.11 3D Cell Culture Market (2017-2030): Conservative Scenario (USD Billion)
 
Table 15.12 3D Cell Culture Market (2017-2030): Distribution by Application (USD Billion)
 
Table 15.13 3D Cell Culture Market: Share by Application, 2017, 2030 (%)
 
Table 15.14 3D Cell Culture Market: Share by Scaffold Format, 2017 (USD Billion)
 
Table 15.15 3D Cell Culture Market: Share by Product Type, 2017 (%)
 
Table 15.16 3D Cell Culture Market: Share by Geography, 2017, 2030 (%)
 
Table 15.17 3D Cell Culture Market: Share by End Use, 2017, 2030 (%)
 
Table 15.18 3D Cell Culture Market: Leading Players, 2017 (%)
 
Table 15.19 Survey Analysis: Distribution by Type of Company
 
Table 15.20 Survey Analysis: Distribution by Location of Respondents
 
Table 15.21 Survey Analysis: Distribution by Seniority Level of Respondents
 
Table 15.22 Survey Analysis: Distribution by Focus Area of the Company
 
Table 15.23 Survey Analysis: Category of Lead Product(s)
 
Table 15.24 Survey Analysis: Nature of Matrices
 
Table 15.25 Survey Analysis: Status of Development of Lead Product(s)
 
Table 15.26 Survey Analysis: Source of 3D Cultured Cells
 
Table 15.27 Survey Analysis: Distribution by Application of 3D Cell Culture Products
 
Table 15.28 Survey Analysis: Distribution by Likely Size of 3D Cell Culture Market
 
Table 15.29 Overall 3D Cell Culture Market: Conservative, Base and Optimistic Scenarios, 2017-2030 (USD Billion)
 
 
The following companies and organizations have been mentioned in the report:
 
1. 101Bio
2. 3D Biomatrix
3. 3D Biotek
4. 4titude®
5. AbbVie
6. Accellta
7. ACEA Biosciences
8. Advanced BioMatrix
9. AIM Biotech
10. AK Biomedical
11. Akron Biotech
12. Alnylam Pharmaceuticals 
13. Alphabioregen
14. AMS Biotechnology 
15. Antleron
16. Applikon Biotechnology
17. ARL Designs
18. AstraZeneca 
19. AUCTEQ Biosystems
20. AvantiCell Science
21. AxoSim
22. Bangalore Integrated System Solutions Tissue Growth Technologies (BiSS TGT)
23. BASF
24. BD Biosciences
25. BellBrook Labs 
26. Benitec Biopharma
27. Bio-Byblos Biomedical
28. BioCellChallenge
29. BioConnect 
30. Biogelx
31. Biomaterials
32. BioMedical Tissues
33. Biomerix
34. Biomimiq
35. Biopta
36. Biotronix 
37. Boston Institute of Biotechnology
38. Bristol-Myers Squibb
39. BRTI Life Sciences
40. Celartia
41. Celenys
42. Cell Culture Company 
43. Cellec Biotek
44. Cellendes
45. Cellevate
46. CellSpring
47. CellSystems
48. CelVivo 
49. CESCO BioProducts
50. Cherry Biotech
51. China Regenerative Medicine International
52. China Stem Cell Clinical Applications Centre
53. CN Bio Innovations 
54. Corning Life Sciences 
55. Cosmo Bio
56. Covance
57. Cyprotex
58. CYTOO
59. Dunn Labortechnik 
60. Durham University
61. East River BioSolutions
62. EBERS
63. Ectica Technologies
64. EMD Millipore
65. Emulate
66. EPISKIN  
67. Epithelix
68. Eppendorf
69. ESI BIO
70. ETH Zurich
71. Fennik Life Sciences
72. FiberCell Systems
73. Fraunhofer IGB
74. Fraunhofer IWS
75. FUJIFILM
76. GE Healthcare
77. GeneON 
78. GlaxoSmithKline
79. Global Cell Solutions
80. Greiner Bio-One 
81. HµREL® Corporation
82. Hamilton Company
83. HK International Regenerative Centre
84. Hokkaido Soda 
85. Humeltis
86. Imperial College London
87. InSphero
88. Instron
89. InvitroCue
90. InvivoSciences
91. Iris Biosciences
92. Japan Vilene
93. Johnson & Johnson
94. J-TEC
95. KU Leuven
96. Kirkstall
97. KIYATEC
98. Koken 
99. Kollodis BioSciences
100. Kuraray 
101. LAMBDA Laboratory Instruments
102. Leibniz Research Centre for Working Environment and Human Factors 
103. Lena Biosciences
104. LFB Biomanufacturing
105. Life Technologies
106. Lifecore Biomedical
107. Linari Engineering
108. Locate Therapeutics
109. Lonza
110. LuoLabs
111. Massachusetts Institute of Technology
112. MatTek 
113. MBL International
114. MD Biosciences
115. Menicon Life Science
116. Merck
117. MicroTissues
118. MIMETAS
119. Mirus Bio 
120. MRC Centre for Drug Safety Science 
121. Nano3D Biosciences
122. Nanofiber Solutions
123. Nanogaia
124. National Cancer Institute
125. NC3Rs
126. Neuromics
127. Nortis
128. Novadip
129. ORGANOGENIX
130. Organovo 
131. PBS Biotech
132. PELOBiotech
133. PepGel
134. Percell Biolytica
135. Pfizer
136. Pishon Biomedical
137. Pluristem Therapeutics
138. ProBioGen
139. Promega
140. ProSys
141. Protista 
142. QGel Bio
143. Quinxell Technologies
144. Radboudumc 
145. RealBio Technology
146. RegeneMed
147. Reinnervate
148. ReproCELL
149. Roche
150. Sanofi
151. Sarstedt
152. Sartorius Stedim Biotech
153. SCIVAX Life Sciences
154. Seres Therapeutics
155. Sigma-Aldrich
156. SKE Research Equipment
157. SkinAxis
158. SoloHill Engineering
159. SpheriTech
160. StemCell Systems
161. STEMCELL Technologies
162. Stemmatters 
163. Stratatech
164. StratiCELL
165. Sumitomo Bakelite
166. SUN Bioscience
167. Synthecon
168. SynVivo
169. TAP Biosystems
170. TARA Biosystems
171. The Well Bioscience
172. Thermo Fisher Scientific
173. Tianjin Weikai Bioeng
174. TissueClick
175. TissUse
176. Trevigen
177. TU Berlin
178. TU Dortmund
179. UB-Care
180. Univalor
181. University College London
182. University of Liverpool
183. University of Oxford
184. University of Pittsburgh 
185. University of Zaragoza
186. University of Zurich
187. University of Würzburg
188. UPM Biochemicals
189. Utrecht University 
190. Viscofan BioEngineering
191. Vivo Biosciences
192. Wyss Institute at Harvard University
 

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